Rigby, Rachael - Lancaster University - The Division of Biomedical and Life Sciences

研究领域

My research interests lie in mechanisms of repair and renewal of the intestinal epithelium. During diseases such as colon cancer and IBD, epithelial repair homeostasis is disrupted. My research focuses on the interplay between luminal bacteria and the epithelium through a family of proteins termed suppressors of cytokine signalling (SOCS) which are important mediators of cancer and inflammation

近期论文

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Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosisRigby, R.J., Carr, J., Orgel, K., King, S.L., Lund, P.K., Dekaney, C.M. 09/2016 In: Gut Microbes. 7, 5, p. 414-423. 10 p. Intestinal epithelial Suppressor of Cytokine Signaling (SOCS) 3 enhances microbial induced inflammatory TNFα, contributing to epithelial barrier dysfunctionThagia, I., Shaw, E.J., Smith, E., Else, K.J., Rigby, R.J. 1/01/2015 In: American Journal of Physiology-Gastrointestinal and Liver Physiology. 308, 1, p. G25-G31. 7 p. Human gut dendritic cells drive aberrant gut-specific T-cell responses in ulcerative colitis, characterized by increased IL-4 production and loss of IL-22 and IFNγMann, E.R., Bernardo, D., Ng, S.C., Rigby, R.J., Al-hassi, H.O., Landy, J., Peake, S.T.C., Spranger, H., English, N.R., Thomas, L.V., Stagg, A.J., Knight, S.C., Hart, A.L. 1/12/2014 In: Inflammatory Bowel Diseases. 20, 12, p. 2299-2307. 9 p. Cannabinoid-induced autophagy regulates suppressor of cytokine signaling (SOCS)-3 in intestinal epitheliumKoay, L., Rigby, R., Wright, K. 15/07/2014 In: American Journal of Physiology-Gastrointestinal and Liver Physiology. 307, p. G140-G148. 9 p. Suppressor of Cytokine signalling 3 (socs3) impacts on intestinal epithelial cell proliferation during intestinal helminth infectionShaw, E., Else, K., Rigby, R. 06/2014 Suppressor of cytokine signalling three regulated intestinal epithelial cell turnover: impact on microbial resistanceShaw, E., Else, K., Rigby, R. 2014 Inflammation Enhances Resection-Induced Intestinal Adaptive Growth in IL-10 Null MiceSpeck, K.E., Garrison, A.P., Rigby, R.J., von Allmen, D.C., Lund, P.K., Helmrath, M.A. 1/06/2011 In: Journal of Surgical Research. 168, 1, p. 62-69. 8 p. The role of suppressor of cytokine signalling 3 in regulating TLR-mediated intestinal epithelial cell homeostasis and repairThagia, I., Rigby, R. 12/2010 In: Clinical and Experimental Immunology. 131, 2 p. High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in MouseDing, S., Chi, M.M., Scull, B.P., Rigby, R., Schwerbrock, N.M.J., Magness, S., Jobin, C., Lund, P.K. 16/08/2010 In: PLoS ONE. 5, 8, p. -. 13 p. A new animal model of postsurgical bowel inflammation and fibrosis: the effect of commensal microfloraRigby, R.J., Hunt, M.R., Scull, B.P., Simmons, J.G., Speck, K.E., Helmrath, M.A., Lund, P.K. 08/2009 In: Gut. 58, 8, p. 1104-1112. 9 p. Intestinal Epithelial Cell (IEC)-Specific Deletion of Suppressor of Cytokine Signaling 3 (SOCS3) in Interleukin-10 Null Mice Promotes Duodenal Tumors Independent of Inflammation: Detection with a Cathepsin-B Activatable Molecular ProbeScull, B., Rigby, R.J., Newton, V.A., Hamilton, K., Morgan, D., Lund, P.K. 05/2009 In: Gastroenterology. 136, 5 Supplement 1, 1 p. What Are the Mechanisms of Fibrosis in IBD?Lund, P.K., Rigby, R.J. 10/2008 In: Inflammatory Bowel Diseases. 14, Supplement 2, 2 p. Bacterial-dependent up-regulation of intestinal bile acid binding protein and transport is FXR-mediated following ileo-cecal resectionDekaney, C.M., von Allmen, D.C., Garrison, A.P., Rigby, R.J., Lund, P.K., Henning, S.J., Helmrath, M.A. 08/2008 In: Surgery. 144, 2, p. 174-181. 8 p. Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in miceDekaney, C.M., Fong, J.J., Rigby, R.J., Lund, P.K., Henning, S.J., Helmrath, M.A. 11/2007 In: American Journal of Physiology-Gastrointestinal and Liver Physiology. 293, 5, p. G1013-G1022. 10 p. Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colonRigby, R.J., Simmons, J.G., Greenhalgh, C.J., Alexander, W.S., Lund, P.K. 19/07/2007 In: Oncogene. 26, 33, p. 4833-4841. 9 p. SOC-ing it to tumors: suppressors of cytokine signaling as tumor repressorsLund, P.K., Rigby, R.J. 07/2006 In: Gastroenterology. 131, 1, 3 p. Characteristics of intestinal dendritic cells in inflammatory bowel diseasesHart, A.L., Al-Hassi, H.O., Rigby, R.J., Bell, S.J., Emmanuel, A.V., Knight, S.C., Kamm, M.A., Stagg, A.J. 07/2005 In: Gastroenterology. 129, 1, p. 50-65. 16 p. Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuliRigby, R.J., Knight, S.C., Kamm, M.A., Stagg, A.J. 02/2005 In: Clinical and Experimental Immunology. 139, 2, p. 245-256. 12 p. Migration and maturation of human colonic dendritic cellsBell, S.J., Rigby, R., English, N., Mann, S.D., Knight, S.C., Kamm, M.A., Stagg, A.J. 15/04/2001 In: Journal of Immunology. 166, 8, p. 4958-4967. 10 p.