Parkin, Edward - Lancaster University - The Division of Biomedical and Life Sciences

个人简介

1995 Ph.D. (Plant biochemistry), University of Central Lancashire, Preston 1990 B.Sc.(Hons) Biochemistry, Lancaster University 1995-1998 Research Fellow, University of Leeds 1998-2001 Research Fellow, University of Leeds 2001-2004 Research Fellow, University of Leeds 2004-2006 Senior Experimental Officer, University of Leeds 2007-present Lecturer in Biochemistry, Lancaster University

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Pyruvate dehydrogenase kinase inhibition: reversing the Warburg effect in cancer therapyBell, H., Parkin, E.T. 23/06/2016 Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration: disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signalingDelury, C.P., Hart, C., Brown, M., Clarke, N., Parkin, E.T. 25/03/2016 In: Biochemical and Biophysical Research Communications. 472, 1, p. 255-261. 7 p. The E1 copper binding domain of full-length amyloid precursor protein promotes epithelial to mesenchymal transition in DU145 cells in isoform-specific mannerGough, M., Delury, C., Parkin, E. 2015 In: International Journal of Biochemistry Research and Review. 6, 1, p. 264-273. 10 p. The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's diseaseGough, M., Blanthorn-Hazell, S., Parkin, E.T. 2015 In: Journal of Alzheimer's Disease. 43, 4, p. 1163-1168. 6 p. The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cellsGough, M., Blanthorn-Hazell, S., Delury, C., Parkin, E. 31/10/2014 In: Biochemical and Biophysical Research Communications. 453, 4, p. 741-747. 7 p. The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell linesHicks, D.A., Makova, N.Z., Gough, M., Parkin, E.T., Nalivaeva, N.N., Turner, A.J. 6/09/2013 In: Journal of Biological Chemistry. 288, 36, p. 26039-26051. 13 p. Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S., Parkin, E. 2/08/2013 In: International Journal of Biochemistry Research and Review. 3, 4, p. 278-290. 13 p. Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signalling and adhesion proteins and promotes the invasion of prostate cancer epithelial cellsParr-Sturgess, C.A., Tinker, C.L., Hart, C.A., Brown, M.D., Clarke, N.W., Parkin, E.T. 10/2012 In: Molecular Cancer Research. 10, 10, p. 1282-1293. 12 p. Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's diseaseGough, M., Parr-Sturgess, C., Parkin, E. 2011 In: Biochemistry Research International. 2011, 13 p. Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's diseaseTaylor, M., Moore, S., Mayes, J., Parkin, E., Beeg, M., Canovi, M., Gobbi, M., Mann, D.M.A., Allsop, D. 2010 In: Biochemistry. 49, 15, p. 3261-3272. 12 p. Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated eventParr-Sturgess, C.A., Rushton, D.J., Parkin, E.T. 2010 In: Biochemical Journal. 432, 2, p. 283-294. 12 p. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor proteinHarris, B., Pereira, I., Parkin, E. 16/10/2009 In: Brain Research. 1296, n/a, p. 203-215. 13 p. Role of ADAMs in the ectodomain shedding and conformational conversion of the prion proteinTaylor, D.R., Parkin, E.T., Cocklin, S.L., Ault, J.R., Ashcroft, A.E., Turner, A.J., Hooper, N.M. 21/08/2009 In: Journal of Biological Chemistry. 284, 34, p. 22590-22600. 11 p. A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10Parkin, E., Harris, B. 03/2009 In: Journal of Neurochemistry. 108, 6, p. 1464-1479. 16 p. Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosisWilkinson, D.K., Turner, E.J., Parkin, E.T., Garner, A.E., Harrison, P.J., Crawford, M., Stewart, G.W., Hooper, N.M. 01/2008 In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778, 1, p. 125-132. 8 p. Alpha-Secretase and Alzheimer's diseaseParkin, E. 2008 In: Recent advances in the biology of secretases, key proteases in Alzheimer's disease. Research Signpost p. 183-211. 29 p. ISBN: 978-81-308-0263-3. Cellular pion protein regulates beta-secretase cleavage of the Alzheimers amyloid precurs protein.Parkin, E., Watt, N.T., Hussain, I., Eckman, E.A., Eckman, C.B., Manson, J.C., Baybutt, H.N., Turner, A.J., Hooper, N.M. 26/06/2007 In: Proceedings of the National Academy of Sciences. 104, 26, p. 11062-11067. 6 p. Angiotensin-converting enzyme as a GPlase : a critical reevaluation.Leisle, L., Parkin, E.T., Turner, A.J., Hooper, N.M. 11/2005 In: Nature Medicine. 11, 11, p. 1139-1140. 2 p. Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2).Lambert, D.W., Yarski, M., Warner, F.J., Thornhill, P., Parkin, E.T., Smith, A.I., Hooper, N.M., Turner, A.J. 26/08/2005 In: Journal of Biological Chemistry. 280, 34, p. 30113-30119. 7 p. Herpes simplex virus interferes with amyloid precursor protein processing.Shipley, S.J., Parkin, E.T., Itzhaki, R.F., Dobson, C.B. 18/08/2005 In: BMC Microbiology. 5, p. 48. The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.Allinson, T.M.J., Parkin, E.T., Condon, T.P., Schwager, S.L.U., Sturrock, E.D., Turner, A.J., Hooper, N.M. 06/2004 In: European Journal of Biochemistry. 271, 12, p. 2539-2547. 9 p. Dual Mechanisms for Shedding of the Cellular Prion Protein.Parkin, E.T., Watt, N.T., Turner, A.J., Hooper, N.M. 19/03/2004 In: Journal of Biological Chemistry. 279, 12, p. 11170-11178. 9 p. Secretase-mediated cell surface shedding of the angiotensin-converting enzyme.Parkin, E.T., Turner, A.J., Hooper, N.M. 2004 In: Protein and Peptide Letters. 11, p. 423-432. 10 p. ADAMs family members as amyloid precursor protein -secretases.Allinson, T.M.J., Parkin, E.T., Turner, A.J., Hooper, N.M. 1/11/2003 In: Journal of Neuroscience Research. 74, 3, p. 342-352. 11 p. The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.Parkin, E.T., Tan, F., Skidgel, R.A., Turner, A.J., Hooper, N.M. 1/08/2003 In: Journal of Cell Science. 116, 15, p. 3079-3087. 9 p.