McKean, Paul - Lancaster University - The Division of Biomedical and Life Sciences

个人简介

BSc (Hons) Zoology, University of Nottingham, 1985 Ph.D. University of Nottingham, 1989 1989 -1992 Postdoctoral research assistant, Division of Parasitology, National Institute for Medical Research, Mill Hill London Beit Memorial Fellow for Medical Research, Department of Biochemistry, Imperial College, London. 1995 -1999 Postdoctoral research assistant, Department of Biochemistry, Imperial College, London. 1999 - 2001 Research Fellow, School of Biological Sciences, University of Manchester Lecturer in Biological Sciences, Lancaster University Senior Lecturer in Biological Sciences, Lancaster University

研究领域

The major research interest of my laboratory is in the cell biology of the flagellated protozoan parasites Trypanosoma brucei and Leishmania major. My interest in these organisms is two-fold: firstly because these organisms are parasites of medical and veterinary importance; and secondly because they are useful model organisms in which to study the biogenesis of the eukaryotic flagellum. By providing a better understanding of the molecular composition of the eukaryotic flagellum and the roles of specific proteins we aim to provide a greater understanding of human diseases that are characterised by functional and/or structural abnormalities of cilia and flagella

近期论文

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Modulation of flagellum attachment zone protein FLAM3 and regulation of the cell shape in Trypanosoma brucei life cycle transitionsSunter, J.D., Benz, C., Andre, J., Whipple, S., McKean, P.G., Gull, K., Ginger, M.L., Luke?, J. 15/08/2015 In: Journal of Cell Science. 128, 16, p. 3117-3130. 14 p. Eukaryotic flagella: variations in form, function, and composition during evolutionMoran, J., McKean, P., Ginger, M. 1/12/2014 In: Bioscience. 64, 12, p. 1103-1114. 12 p. An alternative model for the role of RP2 in flagellum assembly in the African trypanosome: RP2 function in T. bruceiAndre, J., Kerry, L., Qi, X., Hawkins, E., Dri?yt?, K., Ginger, M., McKean, P. 3/01/2014 In: Journal of Biological Chemistry. 289, 1, p. 464 –475. 12 p. Tubulin-binding cofactor C domain-containing protein TBCCD1 orchestrates cytoskeletal filament formationAndre, J., Harrison, S., Towers, K., Qi, X., Vaughan, S., McKean, P., Ginger, M. 12/2013 In: Journal of Cell Science. 126, p. 5350-5356. 7 p. Proteomic insights into parasite biologyGinger, M.L., McKean, P.G., Burchmore, R., Grant, K.M. 08/2012 In: Parasitology. 139, 9, p. 1101-1102. 2 p. Flagellum function and assembly during the Leishmania life cycle.Gluenz, E., Ginger, M.L., McKean, P.G. 08/2010 In: Current Opinion in Microbiology. 13, 4, p. 473-479. 7 p. The flagellar pocket of trypanosomatids: a critical feature for cell morphogenesis and pathogenicityMcKean, P., Gull, K. 2010 In: Structures and organelles in pathogenic protists. Berlin : Springer Verlag p. 87-113. 27 p. Analysis of the trypanosome flagellar proteome using a combined electron transfer collisionally activated dissociation strategy.Hart, S.R., Wai Lau, K.W., Hao, Z., Broadhead, R., Portman, N., Huhmer, A., Gull, K., McKean, P.G., Hubbard, S.J., Gaskell, S.J. 02/2009 In: Journal of The American Society for Mass Spectrometry. 20, 2, p. 167-175. 9 p. Combining RNA interference mutants and comparative proteomics to identify protein component interactions and dependencies in a eukaryotic flagellum.Portman, N., Lacomble, S., Thomas, B., McKean, P.G., Gull, K. 02/2009 In: Journal of Biological Chemistry. 284, 9, p. 5610-5619. 10 p. Swimming with protists : perception, motility and flagellum assembly.Ginger, M.L., Portman, N., McKean, P.G. 11/2008 In: Nature Reviews in Microbiology. 6, 11, p. 838-850. 13 p. An essential quality control mechanism at the eukaryotic basal body prior to intraflagellar transport.Stephan, A., Vaughan, S., Shaw, M.K., Gull, K., McKean, P.G. 10/2007 In: Traffic. 8, 10, p. 1323-1330. 8 p. Cell structure, cell division and cell cycle.Hammarton, T., Wickstead, B., McKean, P.G. 2007 In: Trypanosomes : after the genome. Wymondham : Horizon Bioscience p. 239-280. 42 p. ISBN: 978-1-904933-27-4. Basal body and flagellum mutants reveal a rotational constraint of the central pair microtubules in the axonemes of trypanosomes.Gadelha, C., Wickstead, B., McKean, P.G., Gull, K. 15/06/2006 In: Journal of Cell Science. 119, 12, p. 2405-2413. 9 p. Flagellar motility is required for the viability of the bloodstream trypanosome.Broadhead, R., Dawe, H.R., Farr, H., Griffiths, S., Hart, S.R., Portman, N., Shaw, M.K., Ginger, M.L., Gaskell, S.J., McKean, P.G., Gull, K. 9/03/2006 In: Nature. 440, 7081, p. 224-227. 4 p. Trypanosome IFT mutants provide insight into the motor location for mobility of the flagella connector and flagella membrane formation.Davidge, J.A., Shawcross, E., Dickinson, H.A., Towers, K., Ginger, M.L., McKean, P.G., Gull, K. 2006 In: Journal of Cell Science. 119, 19, p. 3935-3943. 9 p. The flagella connector of Trypanosoma brucei : an unusual mobile transmembrane junction.Briggs, L., McKean, P.G., Baines, A., Moreira-Leite, F., Davidge, J., Vaughan, S., Gull, K. 04/2004 In: Journal of Cell Science. 117, 9, p. 1641-1651. 11 p. Coordination of cell cycle progression and cytokinesis in Trypanosoma brucei.McKean, P.G. 12/2003 In: Current Opinion in Microbiology. 6, 6, p. 600-607. 8 p. γ-Tubulin Functions in the Nucleation of a Discrete Subset of Microtubules in the Eukaryotic Flagellum.McKean, P.G., Baines, A., Vaughan, S., Gull, K. 1/04/2003 In: Current Biology. 13, 7, p. 598-602. 5 p. Myristoyl-CoA:Protein N-Myristoyltransferase, an Essential Enzyme and Potential Drug Target in Kinetoplastid Parasites.Price, H., Menon, M.R., Panethymitaki, C., Goulding, D., McKean, P.G., Smith, D.F. 28/02/2003 In: Journal of Biological Chemistry. 278, 9, p. 7206-7214. 9 p. Plasmodium chabaudi chabaudi AS: modification of acute infection in CBA/Ca mice as a result of pre-treatment with erythrocyte band 3 in adjuvant.O'Dea, K.P., McKean, P.G., Brown, K.N. 10/2002 In: Experimental Parasitology. 102, 2, p. 66-71. 6 p.