Dawson, Neil - Lancaster University - The Division of Biomedical and Life Sciences

研究领域

My research interests are focused on further understanding the mechanisms through which genetic and environmental risk factors for psychiatric and neurodegenerative disease impact on brain functioning, behaviour and cognition. I also have a primary interest in developing and validating translational preclinical models for these diseases for utilization in the drug discovery process, in the hope that we can use these models to identify novel drugs to treat these disorders

近期论文

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Thalamo-cortical communication, glutamatergic neurotransmission and neural oscillations: a unique window into the origins of ScZ?Pratt, J., Dawson, N., Morris, B.J., Grent-'t-Jong, T., Roux, F., Uhlhaas, P.J. 02/2017 In: Schizophrenia Research. 180, p. 4-12. 9 p. Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1Dawson, N., Kurihara, M., Thomson, D.M., Winchester, C.L., McVie, A., Hedde, J.R., Randall, A.D., Shen, S., Seymour, P.A., Hughes, Z.A., Dunlop, J., Brown, J.T., Brandon, N.J., Morris, B.J., Pratt, J.A. 19/05/2015 In: Translational Psychiatry. 5, 12 p. Functional brain connectivity phenotypes for schizophrenia drug discoveryDawson, N., Morris, B.J., Pratt, J. 02/2015 In: Journal of Psychopharmacology. 29, 2, p. 169-177. 9 p. Subanaesthetic ketamine treatment promotes abnormal interactions between neural subsystems and alters the properties of functional brain networksDawson, N., McDonald, M., Higham, D.J., Morris, B.J., Pratt, J.A. 06/2014 In: Neuropsychopharmacology. 39, 7, p. 1786-1798. 13 p. Sustained NMDA receptor hypofunction induces compromised neural systems integration and schizophrenia-like alterations in functional brain networksDawson, N., Xiao, X., McDonald, M., Higham, D.J., Morris, B.J., Pratt, J.A. 02/2014 In: Cerebral Cortex. 24, 2, p. 452-464. 13 p. Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+, K+-ATPase a3 missense mutant miceKirshenbaum, G., Dawson, N., Mullins, J., Johnston, T., Drinkhill, M., Edwards, I., Fox, S., Pratt, J., Brotchie, J., Roder, J., Clapcote, S. 20/03/2013 In: PLoS ONE. 8, 3, 15 p. Subanaesthetic ketamine treatment alters prefrontal cortex connectivity with thalamus and ascending subcortical systemsDawson, N., Morris, B.J., Pratt, J.A. 2013 In: Schizophrenia Bulletin. 39, 2, p. 366-377. 12 p. Modafinil reverses phencyclidine-induced deficits in cognitive flexibility, cerebral metabolism and functional brain connectivityDawson, N., Thompson, R.J., McVie, A., Thomson, D.M., Morris, B.J., Pratt, J.A. 1/09/2012 In: Schizophrenia Bulletin. 38, 3, p. 457-474. 18 p. Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gapPratt, J., Winchester, C., Dawson, N., Morris, B. 07/2012 In: Nature Reviews Drug Discovery. 11, p. 560-579. 20 p. Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the generalized singular value decompositionXiao, X., Dawson, N., MacIntyre, L., Morris, B., Pratt, J., Watson, D., Higham, D. 16/05/2011 In: BMC Systems Biology. 5 Cerbral metabolic responses to 5-HT2A/C receptor activation in mice with genetically modified serotonin transporter (SERT) expressionDawson, N., Ferrington, L., Lesch, K., Kelly, P. 01/2011 In: European Neuropsychopharmacology. 21, 1, p. 117-128. 12 p. Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in ratsvan Donkelaar, E., Kelly, P., Dawson, N., Blokland, A., Prickaerts, J., Steinbusch, H., Ferrington, L. 15/05/2010 In: Journal of Neuroscience Research. 88, 7, p. 1557-1568. 12 p. Sex influences the effect of a lifelong increase in serotonin transporter function on cerebral metabolismDawson, N., Ferrington, L., Olverman, H., Harmar, A., Kelly, P. 1/08/2009 In: Journal of Neuroscience Research. 87, 10, p. 2375-2385. 11 p.