Broughton, Susan - Lancaster University - The Division of Biomedical and Life Sciences

个人简介

BSc (Hons) Biological Sciences from Leicester University (1987) PhD from New York University (2002)

研究领域

My research interests lie in the mechanisms of ageing using the fruit fly, Drosophila melanogaster, as a model organism. I have a particular interest in the role of the insulin/IGF-like signalling pathway in modulating lifespan and age-related functional decline.

近期论文

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Microbes, molecular mimicry and molecules of mood and motivationMorris, J., Broughton, S.J., Wessels, Q.B. 02/2016 In: Medical Hypotheses. 87, p. 40-43. 4 p. The Drosophila insulin receptor independently modulates lifespan and locomotor senescenceHodges, M., Haji Ismail, M.Z.B., Boylan, M., Achall , R., Shirras, A., Broughton, S. 28/05/2015 In: PLoS ONE. Cell-nonautonomous effects of dFOXO/DAF-16 in agingAlic, N., Tullet, J.M., Niccoli, T., Broughton, S., Hoddinott, M.P., Slack, C., Gems, D., Partridge, L. 27/02/2014 In: Cell Reports. 6, 4, p. 608-616. 9 p. Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S., Parkin, E. 2/08/2013 In: International Journal of Biochemistry Research and Review. 3, 4, p. 278-290. 13 p. DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutritionBroughton, S.J., Slack, C., Alic, N., Metaxakis, A., Bass, T.M., Driege, Y., Partridge, L. 06/2010 In: Aging Cell. 9, 3, p. 336-46. 11 p. Molecular evolution and functional characterization of Drosophila insulin-like peptidesGr?nke, S., Clarke, D., Broughton, S., Andrews, T.D., Partridge, L. 2010 In: PLOS Genetics. 6, 2 The endosymbiont Wolbachia increases insulin/IGF-like signalling in DrosophilaIkeya, T., Broughton, S., Alic, N., Grandison, R., Partridge, L. 11/2009 In: Proceedings of the Royal Society B: Biological Sciences. 276, 1674, p. 3799-3807. 9 p. Insulin/IGF-like signalling, the central nervous system and agingBroughton, S., Partridge, L. 2009 In: Biochemical Journal. 418, 1, p. 1-12. 12 p. Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPsBroughton, S., Alic, N., Slack, C., Bass, T., Ikeya, T., Vinti, G., Tommasi, A.M., Driege, Y., Hafen, E., Partridge, L. 2008 In: PLoS ONE. 3, 11 Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligandsBroughton, S.J., Piper, M.D.W., Ikeya, T., Bass, T.M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D.J., Leevers, S.J., Partridge, L. 22/02/2005 In: Proceedings of the National Academy of Sciences. 102, 8, p. 3105-3110. 6 p. Excitatory and inhibitory switches for courtship in the brain of Drosophila melanogasterBroughton, S.J., Kitamoto, T., Greenspan, R.J. 6/04/2004 In: Current Biology. 14, 7, p. 538-547. 10 p. Conditioning deficits of CaM-kinase transgenic Drosophila melanogaster in a new excitatory courtship assayBroughton, S.J., Tully, T., Greenspan, R.J. 2003 In: Journal of Neurogenetics. 17, 1, p. 91-102. 12 p. Transport of CaM kinase along processes elicited by neuronal contact evokes an inhibition of arborization and outgrowth in D. melanogaster cultured neuronsBroughton, S.J., Kane, N.S., Yoder, M., Greenspan, R.J., Robichon, A. 15/09/1996 In: Journal of Cellular Biochemistry. 62, 4, p. 484-494. 11 p. Endogenously inhibited protein kinase C in transgenic Drosophila embryonic neuroblasts down regulates the outgrowth of type I and II processes of cultured mature neuronsBroughton, S.J., Kane, N.S., Arthur, B., Yoder, M., Greenspan, R.J., Robichon, A. 15/03/1996 In: Journal of Cellular Biochemistry. 60, 4, p. 584-599. 16 p.