Allsop, David - Lancaster University - The Division of Biomedical and Life Sciences

研究领域

I am interested in the pathological role of misfolded 'amyloid' proteins in a range of different human diseases, including some important neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and also late-onset diabetes.

近期论文

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?-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the ?-amyloid aggregation process preserving the monomer speciesPellegrino, S., Tonali, N., Erba, E., Kaffy, J., Taverna, M., Contini, A., Taylor, M.N., Allsop, D., Gelmi, M.L., Ongeri, S. 1/02/2017 In: Chemical Science. 8, 2, p. 1295-1302. 8 p. Retro-inverso peptide inhibitor nanoparticles as potent inhibitors of aggregation of the Alzheimer’s Aβ peptideGregori, M., Taylor, M.N., Salvati, E., Re, F., Mancini, S., Balducci, C., Forloni, G., Zambelli, V., Sesana, S., Michael, M., Michail, C., Kolosov, O.V., Tinker-Mill, C.L., Sherer, M., Harris, S., Fullwood, N.J., Masserini, M., Allsop, D. 02/2017 In: Nanomedicine: Nanotechnology, Biology, and Medicine. 13, 2, p. 723-732. 10 p. Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptideMorris, O., Gregory, J., Kadirvel, M., Henderson, F., Blykers, A., McMahon, A., Taylor, M.N., Allsop, D., Allan, S., Grigg, J., Boutin, H., Prenant, C. 10/2016 In: Applied Radiation and Isotopes. 116, p. 120-127. 8 p. Magnetite pollution nanoparticles in the human brain Maher, B.A., Ahmed, I., Karloukovski, V.V., MacLaren, D., Foulds, P., Allsop, D., Mann, D., Torres-Jardon, R., Calderon-Garciduenas, L. 27/09/2016 In: Proceedings of the National Academy of Sciences. 113, 39, p. 10797-10801. 5 p. Effects of different isoforms of apoE on aggregation of the α- synuclein protein implicated in Parkinson's disease Nouri Emamzadeh, F., Aojula, H., McHugh, P., Allsop, D. 8/04/2016 In: Neuroscience Letters. 618, p. 146-151. 6 p. Designed glycopeptidomimetics disrupt protein?protein interactions mediating amyloid β?peptide aggregation and restore neuroblastoma cell viability Kaffy, J., Brinet, D., Soulier, J., Tonali, N., Fera, K.F., Iacone, Y., Hoffmann, A.R.F., Khemtemourian, L., Crousse, B., Taylor, M.N., Allsop, D., Taverna, M., Lequin, O., Ongeri, S. 10/03/2016 In: Journal of Medicinal Chemistry. 59, 5, p. 2025-2040. 16 p. A preliminary electron microscopic investigation into the interaction between Aβ1-42 peptide and a novel nanoliposome- coupled retro-inverso peptide inhibitor, developed as a potential treatment for Alzheimer's diseaseSherer, M., Fullwood, N.J., Taylor, M., Allsop, D. 1/10/2015 In: Journal of Physics: Conference Series. 644, 1, 4 p. Nanomechanical and nanothermal mapping of initial stages of amyloid fibres formation Kolosov, O., Tovee, P., Tinker-Mill, C., Allsop, D. 15/09/2014 Amyloid β-peptide and Alzheimer's disease Allsop, D., Mayes, J. 18/08/2014 Amyloid-β fibrils in Alzheimer's Disease are not inert when bound to copper ions but can degrade hydrogen peroxide and generate reactive oxygen species Mayes, J., Tinker-Mill, C., Kolosov, O., Zhang, H., Tabner, B., Allsop, D. 25/04/2014 In: Journal of Biological Chemistry. 289, p. 12052-12062. 11 p. Ultrasonic force microscopy for nanomechanical characterization of early and late-stage amyloid-β peptide aggregation Tinker-Mill, C., Mayes, J., Allsop, D., Kolosov, O. 6/02/2014 In: Scientific Reports. 4, 7 p. Correlation of Aβ oligomer levels in matched cerebrospinal fluid and serum samples Kasai, T., Tokuda, T., Taylor, M., Kondo, M., Mann, D.M.A., Foulds, P., Nakagawa, M., Allsop, D. 13/09/2013 In: Neuroscience Letters. 551, p. 17-22. 6 p. A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson’s diseaseFoulds, P., Diggle, P., Mitchell, J.D., Parker, A., Hasegawa, M., Masuda-Suzukake, M., Mann, D.M.A., Allsop, D. 29/08/2013 In: Scientific Reports. 3, 6 p. A novel retro-inverso peptide inhibitor reduces amyloid deposition, oxidation and inflammation and stimulates neurogenesis in the APPswe/PS1ΔE9 mouse model of Alzheimer's DiseaseParthsarathy, V., McClean, P.L., H?lscher, C., Taylor, M., Tinker, C., Jones, G., Kolosov, O., Salvati, E., Gregori, M., Masserini, M., Allsop, D. 2013 In: PLoS ONE. 8, 1, 11 p. A possible key role for redox-active metal ions and soluble oligomers in neurodegenerative diseasesTabner, B., Moore, S., Mayes, J., Allsop, D. 2013 In: Brain diseases and metalloproteins. Boca Raton, Fla. : Pan Stanford p. 11-32. 22 p. ISBN: 978-981-4316-01-9. Electronic ISBN: 978-981-4364-07-2. Utilization of a multiple antigenic peptide as a calibration standard in the BAN50 single antibody sandwich ELISA for A? oligomersKasai, T., Tokuda, T., Taylor, M., Nakagawa, M., Allsop, D. 8/06/2012 In: Biochemical and Biophysical Research Communications. 422, 3, p. 375-380. 6 p. Post mortem cerebrospinal fluid α-synuclein levels are raised in multiple system atrophy and distinguish this from the other α-synucleinopathies, Parkinson's disease and Dementia with Lewy bodiesFoulds, P., Yokota, O., Thurston, A., Davidson, Y., Ahmed, Z., Holton, J., Thompson, J.C., Akiyama, H., Arai, T., Hasegawa, M., Gerhard, A., Allsop, D., Mann, D.M.A. 01/2012 In: Neurobiology of Disease. 45, 1, p. 188-195. 8 p. Nanoscale SPM characterisation of nacre aragonite plates and synthetic human amyloid fibresGrishin, I., Tinker, C., Allsop, D., Robson, A., Kolosov, O. 2012 In: NSTI-Nanotech 2012. Santa Clara, USA : CRC PRESS-TAYLOR & FRANCIS GROUP p. 110-113. 4 p. Phosphorylated α-synuclein as a potential biomarker for Parkinson's disease (Editorial)Foulds, P., Mann, D., Allsop, D. 2012 In: Expert Review of Molecular Diagnostics. 12, 2, 3 p. TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's Syndrome: association with age, hippocampal sclerosis and clinical phenotypeDavidson, Y.S., Raby, S., Foulds, P., Robinson, A., Thompson, J.C., Sikkink, S., Yusuf, I., Amin, H., Duplessis, D., Troakes, C., Al-Sarraj, S., Sloan, C., Esiri, M.M., Prasher, V.P., Allsop, D., Neary, D., Pickering-Brown, S.M., Snowden, J.S., Mann, D.M.A. 12/2011 In: Acta Neuropathologica. 122, 6, p. 703-713. 11 p. Effect of curcumin-associated and lipid ligand-functionalized nanoliposomes on aggregation of the Alzheimer's Aβ peptideTaylor, M., Moore, S., Mourtas, S., Niarakis, A., Re, F., Zona, C., La Ferla, B., Nicotra, F., Masserini, M., Antimisiaris, S.G., Gregori, M., Allsop, D. 10/2011 In: Nanomedicine: Nanotechnology, Biology, and Medicine. 7, 5, p. 541-550. 10 p. The amylin peptide implicated in type 2 diabetes stimulates copper-mediated carbonyl group and ascorbate radical formationMasad, A., Tabner, B.J., Mayes, J., Allsop, D. 15/08/2011 In: Free Radical Biology and Medicine. 51, 4, p. 869-875. 7 p. Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's diseaseFoulds, P., Mitchell, J.D., Parker, A., Turner, R., Green, G., Diggle, P., Hasegawa, M., Taylor, M., Mann, D., Allsop, D. 2011 In: FASEB Journal. 25, 12, p. 4127-4137. 11 p. Hypothesis: soluble Aβ oligomers in association with redox-active metal ions are the optimal generators of reactive oxygen species in Alzheimer's diseaseTabner, B.J., Mayes, J., Allsop, D. 8/10/2010 In: International Journal of Alzheimer's Disease. 2011, 6 p. Parkinson disease: progress towards a molecular biomarker for Parkinson disease Foulds, P., Mann, D.M.A., Mitchell, J.D., Allsop, D. 07/2010 In: Nature Reviews Neurology. 6, 7, p. 359-361. 3 p.