Sinclair, Alex - Kingston University - School of Pharmacy and Chemistry

个人简介

2011 - present Senior Lecturer in Organic and Medicinal Chemistry, Kingston University. 2008 - present Lecturer in Organic and Medicinal Chemistry, Kingston University. 2006 - 2008 Post Doctorial Research Associate, UCL.

研究领域

Development of novel methods for the rapid detection of antibiotic resistant bacteria. Total synthesis of nitrogen containing bioactive natural products. Investigation of novel nitrone cyclisations for the rapid synthesis of complex molecular scaffolds for pharmaceutical library generation and bioactivity screening.

近期论文

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Le Gresley, A, Gudivaka, V, Carrington, S, Sinclair, A and Brown, J E (2016) Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents. Organic & Biomolecular Chemistry, 14, pp. 3069-3079. ISSN (print) 1477-0520 Le Gresley, Adam, Simpson, Emma, Sinclair, Alex, Williams, Neil, Burnett, Gary, Bradshaw, David and Lucas, Robert (2015) The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries. Analytical Methods, 7(6), p. 2323. Sinclair, Alex, Mulcahy, Lauren, Geldeard, Lynsey, Malik, Samerah, Fielder, Mark and Le Gresley, Adam (2013) Development of an in situ culture-free screening test for the rapid detection of Staphylococcus aureus within healthcare environments. Organic & Biomolecular Chemistry, 11(20), pp. 3307-3313. ISSN (print) 1477-0520 Tyrrell, Elizabeth, Mazloumi, Khatebeh, Banti, Donatella, Sajdak, Paulina, Sinclair, Alex and Le Gresley, Adam (2012) The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction. Tetrahedron Letters, 53(33), pp. 4280-4282. ISSN (print) 0040-4039 Tyrrell, Elizabeth, Archer, Roland, Tucknott, Matt, Colston, Kay, Pirianov, Grisha, Ramanthan, Dharahana, Dhillon, Rajdeep, Sinclair, Alex and Skinner, G.A. (2012) The synthesis and anticancer effects of a range of natural and unnatural hop [beta]-acids on breast cancer cells. Phytochemistry Letters, 5(1), pp. 144-149. ISSN (print) 1874-3900 Gresley, Adam le, Kenny, Jackie, Cassar, Claire, Kelly, Alison, Sinclair, Alex and Fielder, Mark D (2012) The application of high resolution diffusion NMR to the analysis of manuka honey. Food Chemistry, 135(4), pp. 2879-86. ISSN (print) 0308-8146 Robbins, Diane , Newton, Annabella F. , Gignoux, Camille , Legeay, Jean-Christophe , Sinclair, Alex, Rejzek, Martin , Laxon , Carly A., Yalamanchili, Sai K. , Lewis, William , O'Connell, Maria A. and Stockman, Robert A. (2011) Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway. Chemical Science, 2(11), pp. 2232-2235. ISSN (print) 2041-6520 Le Gresley, Adam, Abdullah, Ammara, Chawla, Deepak, Desai, Pratchi, Ghosh, Uttam, Gollapalli, Uma , Kiran, Munazza, Lafon, Shehri and Sinclair, Alex (2011) Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays. MedChemComm, 2(6), pp. 466-470. ISSN (print) 2040-2503 Aliev, Abil E., Sinclair, Alex J., Zhou, Shen, Wilden, John D., Caddick, Stephen, Kullmann, Dimitri M. and Rusakov, Dmitri A. (2009) Density functional and spectroscopic studies of nitrogen inversion in substituted dizocilpines. Journal of Physical Organic Chemistry, 22(6), pp. 607-612. ISSN (print) 0894-3230 Sinclair, Alex and Stockman, Robert (2007) Thirty-five years of synthetic studies directed towards the histrionicotoxin family of alkaloids. Natural Product Reports, 24(2), pp. 298-326. ISSN (print) 0265-0568 Sinclair, Alex, Arini, Louise, Rejzek, Martin , Szeto, Peter and Stockman, Robert (2006) Combining Two-Directional Synthesis and Tandem Reactions, Part 8: A Novel Condensation/Michael Addition/Cycloaddition/Fragmentation/Lactamisation Cascade. Synlett, 2006(14), pp. 2321-2324. ISSN (print) 0936-5214 Karatholuvhu, Maheswaran, Sinclair, Alex, Newton, Annabella, Alcaraz, Marie-Lyne, Stockman, Robert and Fuchs, Philip (2006) A Concise Total Synthesis of DL-Histrionicotoxin. Journal of the American Chemical Society, 128(39), pp. 12656-12657. ISSN (print) 0002-7863 Stockman, Robert, Sinclair, Alex, Arini, Louise, Szeto, Peter and Hughes, David (2004) A Two-Directional Synthesis of (+/-)-Perhydrohistrionicotoxin. The Journal of Organic Chemistry, 69(5), pp. 1598-1602. ISSN (print) 0022-3263 Arini, Louise , Sinclair, Alex, Szeto, Peter and Stockman, Robert (2004) Direct synthesis of aliphatic vinyl aziridines. Tetrahedron Letters, pp. 1589-1591.