Gresley, Adam Le - Kingston University - School of Pharmacy and Chemistry

个人简介

2006 - 2008 Postdoctoral Researcher, University of Surrey 2003 - 2005 NIH Research Fellow, Drexel College of Medicine, USA

研究领域

Development of dynamic and static combinatorial libraries of novel G-Quadruplex ligands for the induction of tumor apoptosis and their evaluation using NMR techniques. The conception, synthesis and evaulation of novel "caged" biologically active species (e.g. Caged nitric oxide) for cell signalling/imaging studies. The conception, synthesis and evaluation of a novel class of MRSA detection systems.

近期论文

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Fardus-Reid, Fahmina, Warren, John and Le Gresley, Adam (2016) Validating heteronuclear 2D quantitative NMR. Analytical Methods, 8(9), pp. 2013-2019. ISSN (print) 1759-9660 Le Gresley, A, Gudivaka, V, Carrington, S, Sinclair, A and Brown, J E (2016) Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents. Organic & Biomolecular Chemistry, 14, pp. 3069-3079. ISSN (print) 1477-0520 Le Gresley, Adam, Simpson, Emma, Sinclair, Alex, Williams, Neil, Burnett, Gary, Bradshaw, David and Lucas, Robert (2015) The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries. Analytical Methods, 7(6), p. 2323. Le Gresley, Adam, Fardus, Fahmina and Warren, John (2015) Bias and uncertainty in non-ideal qNMR Analysis. Critical reviews in analytical chemistry / CRC, 45(4), pp. 300-10. ISSN (print) 1547-6510 Sinclair, Alex, Mulcahy, Lauren, Geldeard, Lynsey, Malik, Samerah, Fielder, Mark and Le Gresley, Adam (2013) Development of an in situ culture-free screening test for the rapid detection of Staphylococcus aureus within healthcare environments. Organic & Biomolecular Chemistry, 11(20), pp. 3307-3313. ISSN (print) 1477-0520 Tyrrell, Elizabeth, Mazloumi, Khatebeh, Banti, Donatella, Sajdak, Paulina, Sinclair, Alex and Le Gresley, Adam (2012) The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction. Tetrahedron Letters, 53(33), pp. 4280-4282. ISSN (print) 0040-4039 Gresley, Adam le, Kenny, Jackie, Cassar, Claire, Kelly, Alison, Sinclair, Alex and Fielder, Mark D (2012) The application of high resolution diffusion NMR to the analysis of manuka honey. Food Chemistry, 135(4), pp. 2879-86. ISSN (print) 0308-8146 Le Gresley, Adam, Abdullah, Ammara, Chawla, Deepak, Desai, Pratchi, Ghosh, Uttam, Gollapalli, Uma , Kiran, Munazza, Lafon, Shehri and Sinclair, Alex (2011) Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays. MedChemComm, 2(6), pp. 466-470. ISSN (print) 2040-2503 Le Gresley, Adam, Abdullah, Ammara, Desai, Prachi, Ghosh, Uttam, Gollapalli, Uma, Kiran, Munazza and Lafona, Shehri (2010) Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands. Synthetic Communications, 41(16), pp. 2483-2492. ISSN (print) 0039-7911 Le-Gresley, A and Kuhnert, N (2010) The design and synthesis of acrylato and imino derivatives of calix[4]arene for applications in static and dynamic combinatorial libraries. Journal of Chemical Research, 2, pp. 61-67. ISSN (print) 1747-5198 Kuhnert, Nikolai and Le Gresley, Adam (2008) Synthesis of upper rim calix[4]arene carcerands. Tetrahedron Letters, 49(7), pp. 1274-1276. ISSN (print) 0040-4039 Kuhnert, Nikolai, Le Gresley, Adam, Nicolau, Daniel C. and Lopez-Periago, Ana (2007) Synthesis, self-association and chiroselectivity of isotopically labeled trianglamine macrocycles in the ion trap mass spectrometer. Journal of Labelled Compounds and Radiopharmaceuticals, 50(13), pp. 1215-1223. ISSN (print) 0362-4803 Kuhnert, Nikolai and Le Gresley, Adam (2005) Synthesis and capsule formation of upper rim substituted tetra-acrylamido calix[4]arenes. Organic & Biomolecular Chemistry, 3(11), pp. 2175-2182. ISSN (print) 1477-0520