Ryan, Ali - Kingston University - School of Life Sciences

个人简介

2004 - 2008 PhD in structural biology 2000 - 2004 BSc Biotechnology with a year in industry

研究领域

My primary research interests are in the identification of novel targets for antimicrobial therapeutics and the development of novel strategies to overcome bacterial infection.

近期论文

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Ryan, Ali (2016) Azoreductases in drug metabolism. British Journal of Pharmacology, ISSN (online) 1476-5381 (Epub Ahead of Print) Crescente, Vincenzo, Holland, Sinead M., Kashyap, Sapna, Polycarpou, Elena, Sim, Edith and Ryan, Ali (2016) Identification of novel members of the bacterial azoreductase family in Pseudomonas aeruginosa. Biochemical Journal, 473(5), pp. 549-558. ISSN (print) 0264-6021 Egleton, James E., Thinnes, Cyrille C., Seden, Peter T., Laurieri, Nicola, Lee, Siu Po, Hadavizadeh, Kate S., Measures, Angelina R., Jones, Alan M., Thompson, Sam, Varney, Amy, Wynne, Graham M., Ryan, Ali, Sim, Edith and Russell, Angela J. (2014) Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine [Nu]-acetyltransferase 1. Bioorganic & Medicinal Chemistry, 22(11), pp. 3030-3054. ISSN (print) 0968-0896 Ryan, Ali, Kaplan, Elise, Nebel, Jean-Christophe, Polycarpou, Elena, Crescente, Vincenzo, Lowe, Edward, Preston, Gail M and Sim, Edith (2014) Identification of NAD(P)H Quinone Oxidoreductase Activity in Azoreductases from P. aeruginosa: Azoreductases and NAD(P)H Quinone Oxidoreductases Belong to the Same FMN-Dependent Superfamily of Enzymes. PloS ONE, 9(6), e98551. ISSN (online) 1932-6203 Mahendiran, K., Elie, C., Nebel, J-C., Ryan, A. and Pierscionek, B.K. (2014) Primary sequence contribution to optical function of the eye lens. Scientific Reports, 4, p. 5195. ISSN (online) 2045-2322 Ryan, Ali, Keany, Sebastian, Eleftheriadou, Olga, Ballet, Romain, Cheng, Hung-Yuan and Sim, Edith (2014) Research Letter: Mechanism-based inhibition of HsaD: a C-C bond hydrolase essential for survival of M. tuberculosis in macrophage. FEMS Microbiology Letters, 350(1), pp. 42-47. ISSN (print) 0378-1097 Ryan, Ali, Kaplan, Elise, Laurieri, Nicola, Lowe, Edward and Sim, Edith (2011) Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Scientific Reports, 1, ISSN (online) 2045-2322 Ryan, Ali J., Chung, Chun-wa and Curry, Stephen (2011) Crystallographic analysis reveals the structural basis of the high-affinity binding of iophenoxic acid to human serum albumin. BMC Structural Biology, 11(18), ISSN (online) 1472-6807 Ryan, Ali J., Ghuman, Jamie, Zunszain, Patricia A., Chung, Chun-wa and Curry, Stephen (2011) Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin. Journal of Structural Biology, 174(1), pp. 84-91. ISSN (print) 1047-8477 Ryan, Ali, Laurieri, Nicola, Westwood, Isaac, Wang, Chan-Ju, Lowe, Edward and Sim, Edith (2010) A novel mechanism for azoreduction. Journal of Molecular Biology, 400(1), pp. 24-37. ISSN (print) 0022-2836