Maarabouni , Mirna - Keele University - School of Life Sciences

个人简介

I was appointed at Keele as a Lecturer in the School of Life Sciences in August 2009. Prior to this, I obtained a first class BSc (Hons) in Biochemistry in 1995 and a PhD in cellular pharmacology in 1998, both from Keele. I subsequently was employed as a post-doctoral research fellow in the Apoptosis Research Group led by Prof Gwyn Williams, where my work involved identifying and studying novel molecules which control apoptosis, in order to define new drug targets for the therapy of cancer and other human diseases where apoptosis control is dysfunctional.

研究领域

My research interests are in molecular cell biology and cell signalling i.e. investigating the way that mammalian cells function and communicate. Areas of particular interest include studying the signalling pathways involved in the cell fate decision. Currently, my work concentrates on the elucidation of the signalling pathways initiated by the modulation of the expression of a number of genes and how they eventually cause the destruction of the cell. These genes include those that encode non-coding RNAs (ncRNAs). I am interested in investigating the roles of ncRNAs in the death and survival of human cells and in cancer. I also have a long-standing interest in studying the role of phosphatases in cancer.

近期论文

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Mohammed H, Pickard M, Maarabouni MM. 2016. The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer. Cellular Signalling, vol. 28(9), 1389-1400. doi> link> Almnaseer ZA and Maarabouni MM. 2016. NEAT1, a long non-coding RNA, controls cell survival and is up-regulated in breast cancer. European journal of cancer (vol. 61, pp. S75-S76). Elsevier. doi> Maarabouni MM. 2014. Regulation of The Cell Cycle and Cell Death by Protein Phosphatase 4 in Breast Cancer Cell Lines. Maarabouni MM. 2014. NCRI Cancer Conference 2014. Mourtada-Maarabouni M and Williams GT. 2014. Role of GAS5 noncoding RNA in mediating the effects of rapamycin and its analogues on mantle cell lymphoma cells. Clin Lymphoma Myeloma Leuk, vol. 14(6), 468-473. link> doi>