Mottershead , David - Keele University

个人简介

I joined the School of Pharmacy as a Lecturer in Biochemistry & Cell Biology at the beginning of 2016. From the beginning of 2009 until 2014 I was a Senior Research Fellow in the School of Paediatrics and Reproductive Health, at the University of Adelaide (Australia) heading up a group researching the oocyte-secreted factors GDF9 and BMP15. More recently (2015) I established a biotech consulting company (Mottasis Oy Ltd) based in Helsinki, Finland, specializing in the area of mammalian cell expression of recombinant proteins. My PhD research was carried out in the Biochemistry Dept. at the University of Adelaide (1990), which was followed by a number of Postdoc positions (Boston (USA), Sydney (Australia), Helsinki (Finland))

研究领域

My research interests remain in particular with the growth factors GDF9 & BMP15, focussing on structure/function relationships, signal transduction mechanisms and the development of novel forms with applications for infertility treatment.

近期论文

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Sharkey DJ, Schjenken JE, Mottershead DG, Robertson SA. 2015. Seminal fluid factors regulate activin A and follistatin synthesis in female cervical epithelial cells. Mol Cell Endocrinol, vol. 417, 178-190. link> doi> Mottershead DG, Sugimura S, Al-Musawi SL, Li J-J, Richani D, White MA, Martin GA, Trotta AP, Ritter LJ, Shi J, Mueller TD, Harrison CA, Gilchrist RB. 2015. Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality. J Biol Chem, vol. 290(39), 24007-24020. link> doi> Sugimura S, Ritter LJ, Rose RD, Thompson JG, Smitz J, Mottershead DG, Gilchrist RB. 2015. Promotion of EGF receptor signaling improves the quality of low developmental competence oocytes. Dev Biol, vol. 403(2), 139-149. link> doi> Sutton-McDowall ML, Purdey M, Brown HM, Abell AD, Mottershead DG, Cetica PD, Dalvit GC, Goldys EM, Gilchrist RB, Gardner DK, Thompson JG. 2015. Redox and anti-oxidant state within cattle oocytes following in vitro maturation with bone morphogenetic protein 15 and follicle stimulating hormone. Mol Reprod Dev, vol. 82(4), 281-294. link> doi> Li J, Sugimura S, Mueller TD, White MA, Martin GA, Ritter LJ, Liang X, Gilchrist RB, Mottershead D. 2014. Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes. Molecular Endocrinology, vol. 29(1). doi>