Sparr, Christof - University of Basel - Department of Chemistry

个人简介

Christof received his PhD from the ETH Zurich working in the group of Prof. Ryan Gilmour. He subsequently joined Prof. Dieter Seebach (ETH Zurich) and Prof. Steven V. Ley (University of Cambridge) for postdoctoral research. He then moved to the University of Basel and started his independent research as habilitand mentored by Prof. Karl Gademann in 2013. In 2016 Christof became Assistant Professor and in 2021 Associate Professor of Organic Chemistry. He is recipient of the ETH medal, a SNSF Starting Grant (equivalent to an ERC Starting Grant), the 2017 Werner Prize of the Swiss Chemical Society, the 2018 Ruzicka Prize of the ETH Zurich and an ERC Consolidator Grant. Appointments 2021 – University of Basel Associate Professor of Chemistry 2016 – 2021 University of Basel Assistant Professor of Chemistry 2013 – 2016 University of Basel Independent Researcher / Habilitand Mentor: Prof. Dr. Karl Gademann 2012 – 2012 University of Cambridge Postdoctoral Research Fellow Advisor: Prof. Dr. Steven V. Ley 2011 – 2012 ETH Zurich Postdoctoral Research Fellow Advisor: Prof. Dr. Dieter Seebach Education 2008 – 2011 ETH Zurich PhD in Synthetic Organic Chemistry Advisor: Prof. Dr. Ryan Gilmour 2006 – 2008 ETH Zurich MSc ETH Chemistry Advisor: Prof. Dr. Erick M. Carreira Selected Honors and Awards 2020 ERC Consolidator Grant 2018 Ruzicka Prize of the ETH Zurich 2017 Werner Prize of the Swiss Chemical Society 2014 SNSF Starting Grant 2012 ETH Medal

研究领域

Research in our group centers on the design of conceptually new synthetic methods and the creation of unique molecular structure. Different aspects of selectivity, reaction regulation and valorization of abundant resources inspire us to develop streamlined procedures applicable in both, discovery chemistry and process development. We continually investigate novel approaches for catalyst-stereocontrolled transformations to augment synthetically tractable twofold and higher-order stereogenicity.

近期论文

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Aromatic ring-opening metathesis V. Hutskalova, C. Sparr* Nature 2024, accelerated article preview. Atroposelective Arene-Forming Wittig Reaction by Phosphorus PIII/PV=O Redox Catalysis K. Jana, Z. Zhao, J. Musies, C. Sparr* Angew. Chem. Int. Ed. 2024, 63, e202408159. Atroposelective catalysis T. A. Schmidt,+ V. Hutskalova,+ C. Sparr* Nat. Rev. Chem. 2024, 8, 497. (+ denotes equal contributions). Decarboxylative Nickel- and Photoredox-Catalyzed Aminocarbonylation of (Hetero)Aryl Bromides V. Hutskalova, F. Bou Hamdan,* C. Sparr* Org. Lett. 2024, 26, 2768. Special Issue: Organic Chemistry Driven by Academic-Industrial Collaborations. Catalyst control over pentavalent stereocentres A. Budeev, J. Dong, D. Häussinger, C. Sparr* Nat. Commun. 2023, 14, 8013. Artificial Metalloenzymes for Atroposelective Metathesis T. Vornholt,+ Z. Jončev,+ V. Sabatino, S. Panke, T. R. Ward,* C. Sparr,* M. Jeschek* ChemCatChem 2023, 15, e202301113. Isoacridone dyes with parallel reactivity from both singlet and triplet excited states for biphotonic catalysis and upconversion B. Pfund,+ V. Hutskalova,+ C. Sparr,* O. S. Wenger* Chem. Sci. 2023, 14, 11180. Diastereodivergent Catalysis D. Moser,+ T. A. Schmidt,+ C. Sparr* JACS Au 2023, 3, 2612. (+ denotes equal contributions). Invited Perspective Article . Atroposelective PIII/PV=O Redox Catalysis for the Isoquinoline-Forming Staudinger–aza-Wittig Reaction D. Moser, K. Jana, C. Sparr* Angew. Chem. Int. Ed. 2023, 62, e202309053. Selected as VIP Catalyst Control over Threefold Stereogenicity: Selective Synthesis of Atropisomeric Sulfones with Stereogenic C–S Axes T. A. Schmidt, S. Schumann, A. Ostertag, C. Sparr* Angew. Chem. Int. Ed. 2023, 62, e202302084. Control over Stereogenic N–N Axes by Pd-catalyzed 5-endo-Hydroaminocyclizations V. Hutskalova, C. Sparr* Synthesis 2023, 55, 1770. Special Issue dedicated to Prof. Cristina Nevado, Recipient of the 2021 Dr. Margaret Faul Women in Chemistry Award Atroposelective Arene-Forming Alkene Metathesis Z. Jončev, C. Sparr* Angew. Chem. Int. Ed. 2022, 61, e202211168. Preprint deposited on ChemRxiv. o-Quinodimethane Atropisomers: Enantioselective Synthesis and Stereospecific Transformation J. Dong,+ A. Ostertag,+ C. Sparr* Angew. Chem. Int. Ed. 2022, 61, e202212627. (+ denotes equal contributions). Photocatalytic deracemisation of cobalt(III) complexes with fourfold stereogenicity T. A. Schmidt, C. Sparr* Chem. Comm. 2022, 58, 12172. Pioneering Investigator 2022 X-Ray Crystallographic Studies of Quasi-Racemates for Absolute Configuration Determinations X. Wu, J. Malinčík, A. Prescimone, C. Sparr* Helv. Chim. Acta 2022, 105, e202200117. Special Issue in memory of Professor Jack D. Dunitz Synthesis of Diarylaminoacridinium Photocatalysts by Halogen-Metal Exchange Combined with Directed ortho Metalations M. Jakobi, B. Zilate, C. Sparr* Adv. Synth. Catal. 2022, 364, 3384. Selected as VIP. Special Issue Honoring Prof. Andreas Pfaltz Streamlined Synthesis of Aminoacridinium Photocatalysts with Improved Photostability M. Jakobi, C. Sparr* Org. Process Res. Dev. 2022, 26, 2756. Synthesis of Atropisomeric Two-Axis Systems by the Catalyst- Controlled syn- and anti-Selective Arene-Forming Aldol Condensation D. Moser, C. Sparr* Angew. Chem. Int. Ed. 2022, 61, e202202548. Synthesis and Applications of Acridinium Salts V. Hutskalova, C. Sparr* Science of Synthesis 2022, 15.9.4. Retrosynthetic polyketide disconnections for unnatural aromatics X. Wu, C. Sparr* Trends Chem. 2022, 4, 367. Stereoselective Synthesis of Atropisomeric Acridinium Salts by the Catalyst-Controlled Cyclization of ortho-Quinone Methide Iminiums X. Wu, C. Sparr* Angew. Chem. Int. Ed. 2022, 61, e202201424. The Versatility of the Aryne–Imine–Aryne Coupling for the Synthesis of Acridinium Photocatalysts V. Hutskalova, C. Sparr* Synlett 2022, 33, 1180. Special Issue Honoring Prof. Shunichi Fukuzumi’s 70th Birthday (invited) Synthesis of Helical and Planar Extended-Phenanthridinium Salts V. Hutskalova, A. Prescimone, C. Sparr* Helv. Chim. Acta 2021, 104, e202100182. Special Issue for the 75th birthday of Prof. E. Peter Kündig Catalyst-Controlled Stereoselective Barton–Kellogg Olefination T. A. Schmidt, C. Sparr* Angew. Chem. Int. Ed. 2021, 60, 23911. Selected as VIP Aldehyde-Catalyzed Epoxidation of Unactivated Alkenes with Aqueous Hydrogen Peroxide I. Triandafillidi, M. G. Kokotou, D. Lotter, C. Sparr,* C. G. Kokotos* Chem. Sci. 2021, 12, 10191. Ad Hoc Adjustment of Photoredox Properties by the Late-Stage Diversification of Acridinium Photocatalysts V. Hutskalova, C. Sparr* Org. Lett. 2021, 23, 5143. Catalyst Control over Twofold and Higher-Order Stereogenicity by Atroposelective Arene Formation T. A. Schmidt, C. Sparr* Acc. Chem. Res. 2021, 54, 2764. Monitoring Solid-phase Reactions in Self-assembled Monolayers by Surface-enhanced Raman Spectroscopy D. Scherrer, D. Vogel, U. Drechsler, A. Olziersky, C. Sparr, M. Mayor, E. Lörtscher* Angew. Chem. Int. Ed. 2021, 60, 17981. Catalyst control over sixfold stereogenicity X. Wu,+ R. M. Witzig,+ R. Beaud, C. Fischer, D. Häussinger, C. Sparr* Nat. Catal. 2021, 4, 457. (+ denotes equal contributions). Preprint deposited on ChemRxiv. Organophotocatalytic Aerobic Oxygenation of Phenols in a Visible‐Light Continuous‐Flow Photoreactor J. Wellauer,+ D. Miladinov,+ T. Buchholz,+ J. Schütz, R. T. Stemmler, J. A. Medlock, W. Bonrath, C. Sparr* Chem. Eur. J. 2021, 27, 9748. (+ denotes equal contributions) Catalyst-Controlled Transannular Polyketide Cyclization Cascades: Selective Folding of Macrocyclic Polyketides F. C. Raps, V. C. Fäseke, D. Häussinger, C. Sparr* Angew. Chem. Int. Ed. 2020, 59, 18390. Catalytic Cascade Reactions Inspired by Polyketide Biosynthesis D. Moser, A. Castrogiovanni, D. Lotter, R. M. Witzig, V. C. Fäseke, F. C. Raps, C. Sparr* Chimia 2020, 74, 699. New professors issue JoyaPhos: An Atropisomeric Teraryl Monophosphine Ligand A. Castrogiovanni, D. Lotter, F. R. Bissegger, C. Sparr* Chem.–Eur. J. 2020, 26, 9864. Young chemists special issue Polyketide Cyclizations for the Synthesis of Polyaromatics V. C. Fäseke, F. C. Raps, C. Sparr* Angew. Chem. Int. Ed. 2020, 59, 6975. Design and application of aminoacridinium organophotoredox catalysts B. Zilate, C. Fischer, C. Sparr* Chem. Commun. 2020, 56, 1767. Invited feature article Catalyst Repurposing Sequential Catalysis by Harnessing Regenerated Prolinamide Organocatalysts as Transfer Hydrogenation Ligands F. Bourgeois, J. A. Medlock, W. Bonrath, C. Sparr* Org. Lett. 2020, 22, 110. Modulation of Acridinium Organophotoredox Catalysts Guided by Photophysical Studies C. Fischer,+ C. Kerzig,+ B. Zilate, O. S. Wenger,* C. Sparr* ACS Catal. 2020, 10, 210. (+ denotes equal contributions) Synthesis of Enantioenriched Tetra-ortho-3,3′-substituted Biaryls by Small-Molecule-Catalyzed Noncanonical Polyketide Cyclizations R. M. Witzig, C. Sparr* Synlett 2020, 31, 13. Invited account article