Xu, Xiaoyang - New Jersey Institute of Technology - Department of Chemical and Materials Engineering

个人简介

About Me Dr. Xu joined in 2014 upon finishing his joint postdoctoral training between Harvard and MIT. He completed his Ph.D. at Northwestern University under the supervision of Prof. Chad Mirkin Education ; Harvard University; ; 2014 Massachusetts Institute of Technology; ; 2014 Posdoctoral training; MIT; Chemical Engineering; 2014 postdoctoral training; Harvard Medical School; nanomedicine; 2014 Ph.D.; Northwestern University; Material Chemistry; 2010 B.S.; East China University of Science and Technology; ; 2000

研究领域

His research focus is the development of novel biomaterials and nanotechnologies for a variety of medical applications including diagnosis, bioimaging, drug delivery, and regenerative medicine. He looks at both fundamental and applied questions in the cross-disciplinary fields of biomaterials and medicine in order to develop novel therapeutic methods for the treatment of cancer, obesity, and cardiovascular disease.

近期论文

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Rady E. El-Araby, Qisheng Tu, Ying Xie, Tarek Aboushousha, Zhongyu Li,Xiaoyang Xu, Zoe X. Zhu, Lily Q. Dong, Jake Chen*, "Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes" ; Aging and Disease, 2024. Bin Wang, Maoping Tang, Qijing Chen, William Ho, Yilong Teng, Xiaojian Xiong, Zhitong Jia, Xiuling Li, Xiaoyang Xu*, Xue-Qing Zhang* “Delivery of mRNA Encoding Interleukin-12 and a Stimulator of Interferon Genes Agonist Potentiates Antitumor Efficacy through Reversing T Cell Exhaustion”; ACS. Nano, 2024. Xin Bai, Qijing Chen, Fengqiao Li, Yilong Teng, Maoping Tang, Jia Huang, Xiaoyang Xu, Xue-Qing Zhang. "Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy". Nature Communication 15, 6844 (2024). Mingzhu Gao, Yan Li, William Ho, Chen Chen, Qijing Chen, Fengshi Li, Maoping Tang, Qiuyue Fan, Jieqing Wan, Weifeng Yu, Xiaoyang Xu, Peiying Li, and Xue-Qing Zhang, "Targeted mRNA Nanoparticles Ameliorate Blood–Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization", ACS Nano, 2024 Mingzhu Gao, Maoping Tang, William Ho, Yilong Teng, Qijing Chen, Lei Bu, Xiaoyang Xu, Xue-Qing Zhang, "Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis", ACS Nano, 2023 Fengqiao Li, Xue-Qing Zhang, William Ho, Maoping Tang, Zhongyu Li, Lei Bu, Xiaoyang Xu, "mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy", Nature Communications, 2023 Chenshuang Zhang, Yilong Teng, Fengqiao Li, William Ho, Xin Bai, Xiaoyang Xu, Xue-Qing Zhang, "Nanoparticle-Mediated RNA Therapy Attenuates Nonalcoholic Steatohepatitis and Related Fibrosis by Targeting Activated Hepatic Stellate Cells", ACS Nano, 2023 Guolin Zhao, William Ho, Jinxian Chu, Xiaojian Xiong, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, Xue-Qing Zhang, "Inhalable siRNA Nanoparticles for Enhanced Tumor-Targeting Treatment of KRAS-Mutant Non-Small-Cell Lung Cancer", ACS Appl. Mater. Interfaces, 2023 Zhongyu Li, Xue-Qing Zhang, William Ho, Fengqiao Li, Mingzhu Gao, Xin Bai, Xiaoyang Xu, "Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines". ACS nano, 2022 Zhongyu Li, Xue-Qing Zhang, William Ho, Xin Bai, Dabbu Kumar Jaijyan, Fengqiao Li, Ranjeet Kumar, Afsal Kolloli, Selvakumar Subbian, Hua Zhu, Xiaoyang Xu, "Lipid-Polymer Hybrid “Particle-in-Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID-19 Vaccine". Advanced Functional Materials, 2022 Bai, Xin, Guolin Zhao, Qijing Chen, Zhongyu Li, Mingzhu Gao, William Ho, Xiaoyang Xu, and Xue-Qing Zhang. "Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge." Science Advances 8, no. 25 (2022): eabn7162. 51.pdf Wang, Bin, Maoping Tang, Ziwei Yuan, Zhongyu Li, Bin Hu, Xin Bai, Jinxian Chu, Xiaoyang Xu, and Xue-Qing Zhang. "Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy." Bioactive materials 16 (2022): 232-248. 50.pdf Yuan, Ziwei, Bin Wang, Yilong Teng, William Ho, Bin Hu, Kofi Oti Boakye-Yiadom, Xiaoyang Xu, and Xue-Qing Zhang. "Rational design of engineered H-ferritin nanoparticles with improved siRNA delivery efficacy across an in vitro model of the mouse BBB." Nanoscale 14, no. 17 (2022): 6449-6464. 49.pdf Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment Biomater. Sci., 2021,9, 7603-7616 48.pdf Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis, Front Cell Dev Biol. 2021; 9: 703670. 47.pdf Bin Hu, Mingzhu Gao, Kofi Oti Boakye-Yiadom, William Ho, Wei Yu, Xiaoyang Xu*, Xue-Qing Zhang* "An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing", Bioactive Materials 2021 46.pdf William Ho, Mingzhu Gao, Fengqiao Li, Zhongyu Li, Xue‐Qing Zhang*, Xiaoyang Xu* "Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery", Advanced Healthcare Materials 2021 45.pdf Xue Tian, He Zhu, Shibin Du, Xue-Qing Zhang, Fuqing Lin, Fengtao Ji, Yung-Hao Tsou, Zhongyu Li, Yi Feng, Kathryn Ticehurst, Stephen Hannaford, Xiaoyang Xu, Yuan-Xiang Tao* “Injectable PLGA-coated ropivacaine produces a long-lasting analgesic effect on incisional pain and neuropathic pain”, the Journal of Pain 2020; 22,180-195. download44.pdf Bin Hu, Kofi Oti Boakye-Yiadom, Wei Yu, Zi-wei Yuan, William Ho, Xiaoyang Xu*, Xue-Qing Zhang* “Nanomedicine Approaches for Advanced Diagnosis and Treatment of Atherosclerosis and Related Ischemic Diseases”. Adv. Healthcare Mater. 2020; (in press) download43.pdf Qijing Chen, Mingzhu Gao, Zhongyu Li, Yue Xiaoa, Xin Bai, Kofi Oti Boakye-Yiadom, Xiaoyang Xu*, Xue-Qing Zhang* “Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy”, J. Control. Release 2020; 323, 179-190.download42.pdf Zhongyu Li, William Ho, Xin Bai, Fengqiao Li, Yen-jui Chen, Xue-Qing Zhang, Xiaoyang Xu. "Nanoparticle depots for controlled and sustained gene delivery" Journal of Controlled Release. 2020. download41.pdf Zhize Yuan, Yung-Hao Tsou, Xueqing Zhang, Shixing Huang, Yang Yang, Mingzhu Gao, William Ho, Qiang Zhao, Xiaofeng Ye and Xiaoyang Xu. "Injectable Citrate-Based Hydrogel as an Angiogenic Biomaterial Improves Cardiac Repair after Myocardial Infarction" ACS Applied Materials & Interfaces. 2019. download40.pdf Yung-Hao Tsou, Bin Wang, William Ho, Bin Hu, Pei Tang, Sydney Sweet, Xue-Qing Zhang,and Xiaoyang Xu. "Nanotechnology-Mediated Drug Delivery for the Treatment of Obesity and Its Related Comorbidities" Advanced Healthcare Materials. 2019. download39.pdf Zhanxian Li, Hanxiao Liu, Haixia Li, Yung-Hao Tsou, Yilin Gao, Xiaoyang Xu, Weiwei Dua, Liuhe Wei, Mingming Yu. "Lysosome-targeting NIR ratiometric luminecent upcoversion nanoprobe T toward arginine" Sensors and Actuators B: Chemical 280(2019) 94-101.