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个人简介

浙江大学医学中心“百人计划”研究员 良渚实验室 课题组组长 浙江大学医学院附属第二医院 研究员 国家级青年人才计划入选者 2022- 至今 浙江大学医学中心 研究员 2019-2022 哈佛大学医学院 博士后研究员 2017-2018 哈佛大学医学院 联合培养博士

研究领域

核酸药物 RNA治疗 生物材料 生物医学工程 药物递送

近期论文

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Liu C#, Shi Q#, Huang X, Koo S, Kong N*, Tao W*. mRNA-based cancer therapeutics. Nature Reviews Cancer 2023, 23(8): 526-543. (Highlighted in the "Nobel Prize in Physiology or Medicine 2023" Collection) Ji X, Ge L, Liu C, Tang Z, Xiao Y, Chen W, Lei Z, Gao W, Blake S, De D, Shi B, Zeng X*, Kong N*, Zhang X*, Tao W*. Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics. Nature Communications 2021, 12: 1124. (Web of Science Hot Paper | Highly Cited Paper; Highlighted: Nature Portfolio) Shi Y#, Zhen X#, Zhang Y, Li Y, Koo S, Saiding Q, Kong N*, Liu G*, Chen W*, Tao W*. Chemically Modified Platforms for Better RNA Therapeutics. Chemical Reviews 2024, doi: 10.1021/acs.chemrev.3c00611. Xiao Y, Tang Z, Huang X, Chen W, Zhou J, Liu H, Liu C, Kong N*, Tao W*. Emerging mRNA technologies: Delivery strategies and biomedical applications. Chemical Society Reviews 2022, 51(10): 3828-3845. (Front Cover Paper; Web of Science Highly Cited Paper) Saiding Q#, Zhang Z#, Chen S, Xiao F, Chen Y, Li Y, Zhen X, Khan M, Chen W, Koo S*, Kong N*, Tao W*. Nano-bio interactions in mRNA nanomedicine: Challenges and opportunities for targeted mRNA delivery. Advanced Drug Delivery Reviews 2023, 203: 115116. (Invited Article) Ouyang J, Rao S, Liu R, Wang L, Chen W, Tao W*, Kong N*. 2D Materials-based Nanomedicine: From Discovery to Applications. Advanced Drug Delivery Reviews 2022, 185: 114268. (Invited Article) Jangili P, Kong N*, Kim JH, Zhou J, Liu H, Zhang X, Tao W*, Kim JS*. DNA-Damage-Response-Targeting Mitochondria-Activated Multifunctional Prodrug Strategy for Self-defensive Tumor Therapy. Angewandte Chemie International Edition 2022, 61(16): e202117075. (Angew. Chem. VIP; Front Cover Paper) Kong N, Tao W*, Ling X, Wang J, Xiao Y, Shi S, Ji X, Shajii A, Gan ST, Kim NY, Duda DG, Xie T*, Farokhzad OC*, Shi J*. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition. Science Translational Medicine 2019, 11(523): eaaw1565. Highlighted: F1000Prime Recommendation - Rated Very Good Kong N, Zhang R, Wu G, Sui X*, Wang J, Kim NY, Blake S, De D, Xie T*, Cao Y, Tao W*. Intravesical Delivery of KDM6A-mRNA via Mucoadhesive Nanoparticles Inhibits the Metastasis of Bladder Cancer. Proceedings of the National Academy of Sciences USA 2022, 119(7): e2112696119 (PNAS Direct Submission). (Front Cover Paper; Web of Science Highly Cited Paper; Highlighted: Nature Medicine 2022, 28(6): 1100-1102) Kong N, Zhang H, Feng C, Liu C, Xiao Y, Zhang X, Mei L, Kim JS, Tao W*, Ji X*. Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy. Nature Communications 2021, 12: 4777. (Web of Science Hot Paper | Highly Cited Paper; Highlighted: Nature Portfolio) Kong N, Ji X, Wang J, Sun X, Chen G, Fan T, Liang W, Zhang H, Xie A*, Farokhzad OC*, Tao W*. ROS-Mediated Selective Killing Effect of Black Phosphorus: Mechanistic Understanding and Its Guidance for Safe Biomedical Applications. Nano Letters 2020, 20(5): 3943-3955. (Web of Science Highly Cited Paper) Huang X#, Kong N#(co-first), Zhang X#, Cao Y*, Langer R*, Tao W*. The landscape of mRNA nanomedicine. Nature Medicine 2022, 28(11): 2273–2287. (Featured article by Nature Medicine; Highlighted in the "Nobel Prize in Physiology or Medicine 2023" Collection; Web of Science Hot Paper | Highly Cited Paper) Tang Z#, Kong N#(co-first), Zhang X#, Liu Y, Hu P, Mou S, Liljeström P, Shi J, Tan W, Kim JS, Cao Y, Langer R, Leong K, Farokhzad OC*, Tao W*. A materials science perspective on tackling COVID-19. Nature Reviews Materials 2020, 5(11): 847-860. (Front Cover Paper; Web of Science Highly Cited Paper; Highlighted: Nature Portfolio) Tao W*#, Kong N#(co-first), Ji X#, Zhang Y, Sharma A, Ouyang J, Qi B, Wang J, Xie N, Kang C*, Zhang H*, Farokhzad OC, Kim JS*. Emerging two-dimensional Monoelemental materials (Xenes) for biomedical applications. Chemical Society Reviews 2019, 48(11): 2891-2912. (Front Cover Paper; Web of Science Hot Paper | Highly Cited Paper) Zhu X#, Ji X#, Kong N#(co-first), Chen Y#, Mahmoudi M, Xu X, Ding L, Tao W*, Cai T, Li Y, Gan T, Barrett A, Bharwani Z, Chen H, Farokhzad OC*. Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis Enhanced Synergistic Cancer Therapy. ACS Nano 2018, 12(3): 2922–2938. (Web of Science Highly Cited Paper) Ji X#, Kong N#(co-first), Wang J#, Li W, Xiao Y, Gan ST, Zhang Y, Li Y, Song X, Xiong Q, Shi S, Li Z, Tao W, Zhang H*, Mei L*, Shi J*. A Novel Top‐Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging‐Guided Cancer Therapy. Advanced Materials 2018, 30(36): 1803031. (Cover Paper; Web of Science Highly Cited Paper)

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