个人简介
学习经历
2004.09～2008.06，中国农业大学，食品质量与安全，学士
2008.09～2011.07，中国科学院海洋研究所，海洋药物学，硕士
2012.04～2016.06，昆士兰大学，天然药物化学，博士
工作经历
2016.09～2018.02，加州大学圣地亚哥分校Scripps海洋研究所海洋生物技术与海洋药物研究中心，博士后（Postdoctoral Scholar）
2018.03～2019.04，洛克菲勒大学基因编译小分子实验室，博士后（Postdoctoral Associate）
2019.05～2020.04，南卡罗莱纳大学化学与生物化学学院，研究助理（Research Associate）
2020.05～2022.05，西澳大学分子科学学院，研究助理（Research Associate）
2022.06～至今，山东大学药学院，教授
研究领域
1.微生物抗感染活性天然产物的发现和作用机制
2.微生物活性天然产物的生物合成和基因工程改造
近期论文
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Zhuo Shang#, Zachary Ferris#, Douglas Sweeney, Alexander Chase, Chunhua Yuan, Yvonne Hui, Lukuan Hou, Ethan Older, Dan Xue, Xiaoyu Tang, Weipeng Zhang, Prakash Nagarkatti, Mitzi Nagarkatti, Traci Testerman, Paul Jensen, Jie Li*. Grincamycins P−T: rearranged angucyclines from marine sediment-derived Streptomyces sp. CNZ-748 inhibit the cell lines of rare cancer pseudomyxoma peritonei.Journal of Natural Products, 2021, 84(5), 1638–1648.
Lukuan Hou#, Ying Li#, Qihao Wu, Miyang Li, Xiaoyu Tang, Prakash Nagarkatti, Mitzi Nagarkatti, Lingjun Li, Daping Fan, Tim Bugni,Zhuo Shang*, Jie Li*. Discovery of anti-infective adipostatins through bioactivity-guided isolation and heterologous expression of a type III polyketide synthase.Bioorganic Chemistry, 2021, 112, 104925.
Weijia Li, Li Li, Chao Zhang, Yuanheng Cai, Qiyu Gao, Fulin Wang, Yu Cao, Jinzhong Lin, Jie Li,Zhuo Shang*, Wei Lin*. Investigations into the antibacterial mechanism of action of viridicatumtoxins.ACS Infectious Diseases, 2020, 6(7), 1759–1769.
Zhenquan Sun#,Zhuo Shang#, Nicholas Forelli, Kathy Hiu Laam Po, Sheng Chen, Sean F Brady*, Xuechen Li*. Total synthesis of malacidin A byβ‐hydroxyaspartic acid ligation‐mediated cyclization and absolute structure establishment.Angewandte Chemie International Edition, 2020, 59(45), 19868–19872. (热点文章)
Changsheng Wu#,Zhuo Shang#, Christophe Lemetre, Melinda A. Ternei, Sean F. Brady*. Cadasides, calcium-dependent acidic lipopeptides from the soil metagenome that are active against multidrug resistant bacteria.Journal of the American Chemical Society, 2019, 141(9), 3910–3919.
Zhuo Shang, Jaclyn M. Winter*, Christopher A. Kauffman, Inho Yang, William Fenical*. Salinipeptins: Integrated genomic and chemical approaches reveal D-amino acid-containing ribosomally synthesized and post-translationally modified peptides (RiPPs) from a Great Salt Lake Streptomyces sp.ACS Chemical Biology, 2019, 14(3), 415–425.
Zhuo Shang, Ritesh Raju, Angela A. Salim, Zeinab G. Khalil, and Robert J. Capon*. Cytochalasins from an Australian marine sediment-derived Phomopsis sp. (CMB-M0042F): Acid-mediated intramolecular cycloadditions enhance chemical diversity.Journal of Organic Chemistry, 2017, 82(18), 9704–9709.
Zhuo Shang, Zeinab Khalil, Li Li, Angela A. Salim, Michelle Quezada, Pabasara Kalansuriya, Robert J. Capon*. Roseopurpurins: Chemical diversity enhanced by convergent biosynthesis and forward and reverse Michael additions.Organic Letters, 2016, 18(17), 4340–4343.
Zhuo Shang, Angela A. Salim, Zeinab Khalil, Paul V. Bernhardt, Robert J. Capon*. Fungal biotransformation of tetracycline antibiotics.Journal of Organic Chemistry, 2016, 81(15), 6186–6194. (热点文章)
Zhuo Shang, Angela A. Salim, Zeinab G. Khalil, Michelle Quezada, Paul V. Bernhardt, Robert J. Capon*. Viridicatumtoxins: Expanding on a rare tetracycline antibiotic scaffold.Journal of Organic Chemistry, 2015, 80(24), 12501–12508.
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