Noël, Timothy - University of Amsterdam - Van’t Hoff Institute for Molecular Sciences

个人简介

Timothy Noël is a researcher in the field of synthetic organic chemistry and technology, with a particular interest in the delicate synergy between the two fields. In 2004, Tim earned his MSc degree in Industrial Chemical Engineering before pursuing his passion for synthetic organic chemistry, which led him to complete his PhD in the field at Ghent University in 2009. Following his PhD, he traveled across the Atlantic as a Fulbright Postdoctoral Fellow to work with Professor Stephen L. Buchwald at the Massachusetts Institute of Technology (MIT), where he gained valuable experience and expertise in flow chemistry. Upon returning to Europe, he joined Eindhoven University of Technology as an Assistant Professor in 2012, and later became an Associate Professor in 2017. In 2020, Tim was promoted to Full Professor at the University of Amsterdam, where he is now the Chair of Flow Chemistry. He coordinated the Marie Skłodowska-Curie ETN programs “Photo4Future” (2015-2018) and “PhotoReAct” (2021-2024). He is the editor in chief of Journal of Flow Chemistry and the current president of the Flow Chemistry Society. His research in the area of flow chemistry was recognized with several awards, including the DECHEMA award (2017), the Hoogewerff Youth Prize (2019), the IUPAC-ThalesNano Flow Chemistry Award (2020), the KNCV Gold Medal (2021), ERC Consolidator Grant (2022), the ACS Sustainable Chemistry & Engineering Lectureship Award (2022) and the ChemSocRev Pioneering Investigator Lectureship (2023). He was also named Fellow of the Royal Society of Chemistry in 2024.

研究领域

Photoredox Catalysis Organic Electrochemistry C–H Activation Chemistry Flow Chemistry Chemical Engineering

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Capaldo, L.; Wan, T.; Mulder, R.; Djossou, J. and Noël, T. Visible Light-Induced Halogen-Atom Transfer by N-Heterocyclic Carbene-Ligated Boryl Radicals for Diastereoselective C(sp3)–C(sp2) Bond Formation Chemical Science, 2024, DOI: 10.1039/D4SC02962C Bayley,O.; Savino, E.; Slattery, A.; and Noël, T. Autonomous chemistry: Navigating self-driving labs in chemical and material sciences Matter, 2024, 7, 2382-2398, DOI: 10.1016/j.matt.2024.06.003 Masson,T.; Zondag, S.; Schuurmans, J.; and Noël, T. Open-source 3D printed reactors for reproducible batch and continuous-flow photon-induced chemistry: design and characterization Reaction Chemistry & Engineering, 2024, 9, 2218-2225 DOI: 10.1039/D4RE00081A Pulcinella, A.; Tiwari, P.; Luridiana, A.; Yamazaki, K.; Mazzarella, D.; Sadhoe, A.; Alfano, A.; Tiekink, E.; Hamlin, T. and Noël, T. C1-4 Alkylation of Aryl Bromides with Light Alkanes enabled by Metallaphotocatalysis in Flow. Angewandte Chemie International Edition, 2024, e202413846, DOI: 10.1002/anie.202413846(For the preprint version, see 10.26434/chemrxiv-2024-7mk1c) Spennacchio, M.; Bernus, M.; Stanic, J.; Mazzarella, D.; Colella, M.; Douglas, J.; Boutureira, O. and Noël, T. A Unified Flow Strategy for the Preparation and Use of Trifluoromethyl-heteroatom Anions. ChemRxiv, 2024, DOI: 10.26434/chemrxiv-2024-3bqt6 Schuurmans, J.; Masson, T.; Zondag, S.; Pilon, S.; Bragato, N.; Claros, M.; den Hartog, T. Sastre, F.; van den Ham, J.; Buskens, P.; Fiorani. G. and Noël, T. Light-assisted carbon dioxide reduction in an automated photoreactor system coupled to carbonylation chemistry. ChemRxiv, 2024, DOI: 10.26434/chemrxiv-2024-sz6ng Boronin, E. N.; Svetlakova, M. M.; Vorobyov, I. I.; Malysheva, Y. B.; Polushtaytsev, Y. V.; Mensov, S. N.; Vladimirovich Vorotyntsev, A.; Fedorov, A.; Noël, T. and Nyuchev, A. V. Photochemical organocatalytic heteroarylation of anilines and secondary alicyclic amines in continuous-flow. Reaction Chemistry & Engineering, 2024, 9, 1877-1882, DOI: 10.1039/D4RE00130C Lukas, F.; Findlay, M.; Fillols, M.; Templ, J.; Savino, E.; Martin, B.; Allmendinger, S.; Furegati, M. and Noël, T. Graphitic carbon nitride as a photocatalyst for decarboxylative C(sp2)-C(sp3) couplings via nickel catalysis. Angewandte Chemie International Edition, 2024, e202405902, DOI: 10.1002/anie.202405902 (For the preprint version, see 10.26434/chemrxiv-2024-b7kv6) Bonciolini, S.; Pulcinella, A.; Leone, M.; Schiroli, D.; Luguera Ruiz, A.; Sorato, A.; Dubois, M. A. J.; Gopalakrishnan, R.; Masson, G.; Della Ca’, N.; Protti, S.; Fagnoni, M.; Zysman-Colman, E.; Johansson, M. and Noël, T. Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes. Nature Communications, 2024, 15 (1509), DOI: 10.1038/s41467-024-45804-z (For the preprint version, see 10.26434/chemrxiv-2023-fcl2j) Nagornîi, D.; Raymenants, F.; Kaplaneris, N. and Noël, T. C(sp3)–H sulfinylation of light hydrocarbons with sulfur dioxide via hydrogen atom transfer photocatalysis in flow. Nature Communications, 2024, 15, 5246, DOI: 10.1038/s41467-024-49322-w (For the preprint version, see 10.26434/chemrxiv-2024-djx7b) Kaplaneris, N.; Akdeniz, M.; Fillols, M.; Arrighi, F.; Raymenants, F.; Sanil, G.; Gryko, D. T. and Noël, T. Photocatalytic Functionalization of Dehydroalanine-Derived Peptides in Batch and Flow. Angewandte Chemie International Edition, 2024, e202403271, DOI: 10.1002/anie.202403271 (For the preprint version, see 10.26434/chemrxiv-2024-6fgqv) Mazzarella, D.; Stanic, J.; Bernus, M.; Seyed Mehdi, A.; Henderson, C.; Boutureira, O. and Noël, T. In-flow generation of thionyl fluoride (SOF2) enables the rapid and efficient synthesis of acyl fluorides from carboxylic acids. Journal of the American Chemical Society, 2024, DOI: 10.1021/jacsau.4c00318(For the preprint version, see 10.26434/chemrxiv-2024-z41gc) Alcázar, J.; Anderson, E. A.; Davies, H. M. L.; Febrian, R.; Kelly, C. B.; Noël, T.; Voight, E. A.; Zarate, C; and Zysman-Colman, E. Better Together: Catalyzing Innovation in Organic Synthesis via Academic-Industrial Consortia. Organic Letters, 2024, 26 (14), 2677–2681, DOI: 10.1021/acs.orglett.4c00192 Slattery, A; Wen, Z; Tenblad, P.; Pintossi, D.; Sanjose-Orduna, J.; den Hartog, T. and Noël, T. Automated self-optimization, intensification, and scale-up of photocatalysis in flow. Science, 2024, 383, eadj1817 DOI: 10.1126/science.adj1817 (For the preprint version, see 10.26434/chemrxiv-2023-r0drq) Zondag, S.; Schuurman, J.; Chaudhuri, A.; Visser, R.; Soares, C.; Padoin, N.; Kuijpers, K.; Dorbec, M.; Van der Schaaf, J and Noël, T. Determining photon flux and effective optical path length in intensified flow photoreactors. Nature Chemical Engineering, 2024, DOI: 10.1038/s44286-024-00089-3 (For the preprint version, see 10.26434/chemrxiv-2024-gfk84) Anwar, K.; Capaldo, L.; Wan, T.; Noël, T. and Gómez-Suárez, Modular Synthesis of Congested β2,2-Amino Acids via the Merger of Photocatalysis and Oxidative Functionalisations. Chemical Communication, 2024, 60, 1456-1459, DOI: 10.1039/D3CC06172H (For the preprint version, see 10.26434/chemrxiv-2023-dbc9d) Schuurmans, J.; Masson, T. M.; Zondag, S. D. A.; Buskens, P. and Noël, T. Solar-Driven Continuous CO2 Reduction to CO and CH4 using Heterogeneous Photothermal Catalysts: a Review Outlining Recent Progress and Remaining Challenges. ChemSusChem, 2024, 17 e202301405 DOI: 10.1002/cssc.202301405 Laporte, A.; Masson, T. M.; Zondag, S. D. A. and Noël, T. Multiphasic Continuous-Flow Reactors for Handling Gaseous Reagents in Organic Synthesis: Enhancing Efficiency and Safety in Chemical Processes. Angewandte Chemie International Edition, 2024, 63 e202316108 DOI: 10.1002/anie.202316108 Costa, R.; Vega, C.; Regnier, M.; Capaldo, L.; Wesenberg, L.; Lowe, G.; de Oliveira, K. and Noël, T. Electrosynthesis of Aryliminophosphoranes in Continuous Flow. Advanced Synthesis & Catalysis, 2024, 366, 955-960. DOI: 10.1002/adsc.202300635 Bernus, M.; Mazzarella, D.; Stanic, J.; Zhai, Z.; Vazquez A. Y.; Boutureira, O. Gargano, A. F. G.; Grossmann, T. and Noël, T. A modular flow platform for sulfur(VI) fluoride exchange ligation of small molecules, peptides and proteins. Nature Synthesis, 2024, 3, 185-191, DOI: 10.1038/s44160-023-00441-0 (For the preprint version, see 10.26434/chemrxiv-2023-gngqd) Laktsevich-Iskryk, M.; Krech, A.; Fokin, M.; Kimm, M.; Jarg, T.; Noël, T. and Ošeka, M. Telescoped synthesis of vicinal diamines via ring-opening of electrochemically generated aziridines in flow. Journal of Flow Chemistry, 2024, 14, 139–147, DOI: 10.1007/s41981-023-00296-8 Wan, T.; Capaldo, L; Djossou, J.; Staffa, A.; de Zwart, F; de Bruin, B. and Noël, T. Rapid and Scalable Photocatalytic C(sp2)–C(sp3) Suzuki−Miyaura Cross-Coupling of Aryl Bromides with Alkyl Boranes. Nature Communications, 2024, 15, 4028 DOI: 10.1038/s41467-024-48212-5 (For the preprint version, see 10.26434/chemrxiv-2023-4g3xz) Ioannou, D.; Capaldo, L.; Sanramat, J.; Reek, J. and Noël, T. Accelerated Electrophotocatalytic C(sp3)‒H Heteroarylation Enabled by an Efficient Continuous-Flow Reactor. Angewandte Chemie International Edition, 2023, 62, e202315881 DOI: 10.1002/anie.202315881 (For the preprint version, see 10.26434/chemrxiv-2023-1xbvv) Wesenberg, L. J.; Sivo, A.; Vilé, G. and Noël, T. Ni-Catalyzed Electro-Reductive Cross-Electrophile Couplings of Alkyl Amine-Derived Radical Precursors with Aryl Iodides. The Journal of Organic Chemistry, 2023, DOI: 10.1021/acs.joc.3c00859 Capaldo, L.; Wen, Z. and Noël, T. A field guide to flow chemistry for synthetic organic chemists. Chemical Science, 2023, 14, 4230-4247 DOI: 10.1039/D3SC00992K D. A. Zondag, S.; Mazzarella, D. and Noël, T. Scale-Up of Photochemical Reactions: Transitioning from Lab Scale to Industrial Production. Annual Review of Chemical and Biomolecular Engineering, 2023, 14, 283-300 DOI: 10.1146/annurev-chembioeng-101121-074313 Raymenants, F.; Masson, T.; San Jose Orduna, J. and Noël, T. Efficient C(sp3)-H carbonylation of light and heavy hydrocarbons with carbon monoxide via HAT photocatalysis in flow. Angewandte Chemie International Edition, 2023, e202308563 DOI: 10.1002/anie.202308563 (For the preprint version, see 10.26434/chemrxiv-2023-jbjh2) West, T. Lights, flow, transfer. Nature Synthesis, 2023, 2, 198–199 DOI: 10.1038/s44160-022-00216-z (An interview with Timothy Noël about how flow technologies and photocatalytic methods enable C(sp3)–H functionalization reactions.) Fanini, F.; Luridiana, A.; Mazzarella, D.; Alfano, A. I.; van der Heide, P.; Rincón, J. A.; García-Losada, P.; Mateos, C.; Frederick, M. O.; Nuño, M. and Noël, T. Flow photochemical Giese reaction via silane-mediated activation of alkyl bromides. Tetrahedron Letters 2023, 154380 DOI: 10.1016/j.tetlet.2023.154380 Pulcinella, A.; Bonciolini, S.; Lukas, F.; Sorato, A.; and Noël, T. Photocatalytic Alkylation of C(sp3)−H Bonds Using Sulfonylhydrazones. Angewandte Chemie International Edition 2023, 62 (3), e202215374 DOI: 10.1002/anie.202215374 (For the preprint version, see: 10.26434/chemrxiv-2022-h91bz) Wan, T.; Capaldo, L.; Ravelli, D.; Vitullo, W.; de Zwart, F.; de Bruin, B. and Noël, T. Photoinduced Halogen-Atom Transfer (XAT) by N-heterocyclic carbene boryl radicals for C(sp3)−C(sp3) bond formation. Journal of the American Chemical Society 2023, 145 (2), 991–999 DOI: 10.1021/jacs.2c10444 (For the preprint version, see: 10.26434/chemrxiv-2022-8j1df) Sanjose-Orduna, J.; Silva, R. C.; Raymenants, F.; Reus, B.; Thaens, J.; de Oliveira, K. T.; and Noël, T. Dual role of benzophenone enables a fast and scalable C-4 selective alkylation of pyridines in flow Chemical Science 2022,13, 12527-12532 DOI: 10.1039/D2SC04990B Luridiana, A.; Mazzarella, D.; Capaldo, L.; Rincón, J. A.; García-Losada, P.; Mateos, C.; Frederick, M. O.; Nuño, M.; Buma, W. J.and Noël, T. The Merger of Benzophenone HAT Photocatalysis and Silyl Radical-Induced XAT Enables Both Nickel-Catalyzed Cross-Electrophile Coupling and 1,2-Dicarbofunctionalization of Olefins. ACS Catalysis 2022, 12 (18), 11216–11225 DOI: 10.1021/acscatal.2c03805 Masson, T. M.; Zondag, S. D. A.; Debije, M. G. and Noël, T. Rapid and Replaceable Luminescent Coating for Silicon-Based Microreactors Enabling Energy-Efficient Solar Photochemistry. ACS Sustainable Chemistry & Engineering 2022 10 (32), 10712–10717 DOI: 10.1021/acssuschemeng.2c03390 Capaldo, L.; Bonciolini, S.; Pulcinella, A; Nuno, M. and Noël, T. Modular allylation of C(sp3)−H bonds by combining decatungstate photocatalysis and HWE olefination in flow. Chemical Science 2022, 13 (24), 7325-7331 DOI: 10.1039/D2SC01581A (For the preprint version, see: 10.26434/chemrxiv-2021-5vdm7) Wen, Z.; Pintossi, D.; Nuno, M. and Noël, T. Membrane-based TBADT recovery: increasing the sustainability of continuous-flow photocatalytic HAT transformations. Nature Communications 2022, 13 (6147) DOI: 10.1038/s41467-022-33821-9 (For the preprint version, see: 10.26434/chemrxiv-2022-fdxzn) Bonciolini, S.; Noël, T. and Capaldo, L. Synthetic Applications of Photocatalyzed Halogen-radical mediated Hydrogen Atom Transfer for C−H Bond Functionalization. European Journal of Organic Chemistry 2022, 2022 (34), e202200417 DOI: 10.1002/ejoc.202200417 Bajada, M. A.; Sanjosé-Orduna, J.; Di Liberto, G.; Tosoni, S.; Pacchioni, G.; Noël, T. and Vilé, G. Interfacing single-atom catalysis with continuous-flow organic electrosynthesis. Chemical Society Reviews 2022, 51 (10), 3898-3925 DOI: 10.1039/D2CS00100D Riente, P.; Fianchini, M.; Pericàs, M. A. and Noël, T. Accelerating the Photocatalytic Atom Transfer Radical Addition Reaction Induced by Bi2O3 with Amines: Experiment and Computation. ChemCatChem 2022, 14 (12), e202200319 DOI: 10.1002/cctc.202200319 de Souza, A. A. N.; Bartolomeu, A. de A.; Brocksom, T. J.; Noël, T. and de Oliveira, K. T. Direct Synthesis of α-Sulfenylated Ketones under Electrochemical Conditions. The Journal of Organic Chemistry 2022, 87 (9), 5856-5865 DOI: 10.1021/acs.joc.2c00147 Capaldo, L.; Noël, T. and Ravelli, D. Photocatalytic generation of ligated boryl radicals from tertiary amine-borane complexes: An emerging tool in organic synthesis. Chem Catalysis 2022, 2 (5), 957-966 DOI: 10.1016/j.checat.2022.03.005 Kooli, A.; Wesenberg, L.; Beslać, M.; Krech, A.; Lopp, M.; Noël, T. and Ošeka, M. Electrochemical Hydroxylation of Electron-Rich Arenes in Continuous-Flow. European Journal of Organic Chemistry 2022, 2022 (20), e202200011 DOI: 10.1002/ejoc.202200011 Chaudhuri, A.; Zondag, S. D. A.; Schuurmans, J. H. A.; van der Schaaf, J.; and Noël, T. Scale-Up of a Heterogeneous Photocatalytic Degradation Using a Photochemical Rotor–Stator Spinning Disk Reactor. Organic Process Research & Development 2022, 26 (4), 1279-1288 DOI: 10.1021/acs.oprd.2c00012 Delparish, A.; Uslu, A.; Cao, Y.; de Groot, T.; van der Schaaf, J.; Noël, T. and Neira d’Angelo, M. F. Boosting the valorization of biomass and green electrons to chemical building blocks: A study on the kinetics and mass transfer during the electrochemical conversion of HMF to FDCA in a microreactor. Chemical Engineering Journal 2022, 135393 DOI: 10.1016/j.cej.2022.135393 Noël, T. and Zysman-Colman, E. The promise and pitfalls of photocatalysis for organic synthesis. Chem Catalysis 2022, 2 (3), 468-476 DOI: 10.1016/j.checat.2021.12.015 Wan, T.; Wen. Z.; Laudadio, G.; Capaldo, L.; Lammers, R.; Rincón, J. A.; García-Losada, P.; Mateos, C.; Frederick, M. O.; Boroersma, R. and Noël, T. Accelerated and Scalable C(sp3)–H Amination via Decatungstate Photocatalysis Using a Flow Photoreactor Equipped with High-Intensity LEDs. ACS Central Science 2022, 8 (1), 51-56 DOI: 10.1021/acscentsci.1c01109 Cao, Y.; Padoin, N.; Soares, C. and Noël, T. On the performance of liquid-liquid Taylor flow electrochemistry in a microreactor – A CFD study. Chemical Engineering Journal 2022, 427, 131443 DOI: 10.1016/j.cej.2021.131443 Zondag, S. D. A. ; Masson, T. M.; Debije, M. G. and Noël, T. The development of luminescent solar concentrator-based photomicroreactors: a cheap reactor enabling efficient solar-powered photochemistry. Photochem Photobiol Sci 2022, 21, 705–717 DOI: 10.1007/s43630-021-00130-x Buglioni, L.; Raymenants, F.; Slattery, A.; Zondag, S. D. A. and Noël, T. Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry. Chemical Reviews 2022, 122 (2), 2752-2906 DOI: 10.1021/acs.chemrev.1c00332 Dong, Z.; Zondag, S. D. A.; Schmid, M.; Wen, Z. and Noël, T. A Meso-Scale Ultrasonic Milli-Reactor Enables Gas-Liquid-Solid Photocatalytic Reactions in Flow. Chemical Engineering Journal 2022, 428, 130968 DOI: 10.1016/j.cej.2021.130968