贾知军 - 四川大学 - 华西药学院

个人简介

2020-至今四川大学，研究员 2018-2020 美国加州理工学院，博士后，师从Frances H. Arnold教授（2018诺贝尔化学奖） 2017-2018 德国马克斯•普朗克分子生理所，博士后，师从Herbert Waldmann教授 2012-2016 德国多特蒙德工业大学化学生物学专业，博士，师从Herbert Waldmann教授 2009-2012 四川大学华西药学院药物化学专业，硕士，师从陈应春教授 2005-2009 四川大学生命科学院生物技术基地班，本科

研究领域

综合利用定向进化和从头设计策略，创造非天然的酶功能，从而发展手性药物绿色制造的新方法，以及儿童疾病预防、诊断和治疗的新手段

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Jia, Z.-J., Gao, S., Arnold, F. H.,* Enzymatic Primary Amination of Benzylic and Allylic C(sp3)–H Bonds. J. Am. Chem. Soc., 2020, DOI: 10.1021/jacs.0c03428. Cho, I., Prier, C. K., Jia, Z.-J., Zhang, R. K., Görbe, T., Arnold, F. H.,* Enantioselective Aminohydroxylation of Olefins Catalyzed by an Engineered Hemoprotein. Angew. Chem. Int. Ed. 2018, 58, 3138-3142. Jia, Z.-J., Shan, G., R., Daniliuc, C. G., Antonchick, A. P.,* Waldmann, H.* Enantioselective Synthesis of the Spirotropanyl Oxindole Scaffold through Bimetallic Relay Catalysis. Angew. Chem. Int. Ed. 2018, 57, 14493-14497. Jia, Z.-J., Takayama, H., Futamura, Y., Aono, H., Bauer, J. O., Strohmann, C., Antonchick, * A. P., Osada, * H., Waldmann, H.* Catalytic Enantioselective Synthesis of a Pyrrolizidine–Alkaloid-Inspired Compound Collection with Antiplasmodial Activity. J. Org. Chem. 2018, 13, 7033-7041. Jia, Z.-J., Merten, C., Knauer, L., Murarka, S., Strohmann, C., Waldmann, H.* Biology-Oriented Synthesis of Decahydro-4,8-epoxyazulene Scaffolds. Synlett 2017, 28, 2918-2922. Jia, Z.-J., Merten, C., Gontla, R., Daniliuc, C. G., Antonchick, A. P.,* Waldmann, H.* General Enantioselective C‒H Activation with Efficiently Tunable Cyclopentadienyl Ligands. Angew. Chem. Int. Ed. 2017, 56, 2429-2434. Murarka, S., Jia, Z.-J., Merten, C., Daniliuc C.-G., Antonchick, A. P.,* Waldmann, H.* Rhodium(II)-Catalyzed Enantioselective Synthesis of Troponoids. Angew. Chem. Int. Ed. 2015, 54, 7653-7656. Jia, Z.-J., Daniliuc, C. G., Antonchick, A. P.,* Waldmann, H.* Phosphine-Catalyzed Dearomatizing [3+2] Annulations of Isoquinolinium Methylides with Allenes. Chem Commun. 2015, 51, 1054-1057. Takayama, H., Jia, Z.-J., Kremer, L., Bauer J. O., Strohmann, C., Ziegler, S., Antonchick, A. P.,* Waldmann, H.* Discovery of Inhibitors of the Wnt and Hedgehog Signaling Pathways through the Catalytic Enantioselective Synthesis of an Iridoid-Inspired Compound Collection. Angew. Chem. Int. Ed. 2013, 52, 12404-12408. Ma, C., Jia, Z.-J., Liu, J.-X, Zhou, Q.-Q., Dong, L., Chen, Y.-C.* A Concise Assembly of Electron-Deficient 2,4-Dienes and 2,4-Dienals: Regio- and Stereoselective exo-Diels–Alder and Redox Reactions through Sequential Amine and Carbene Catalysis. Angew. Chem., Int. Ed. 2013, 52, 948-951. Jia, Z.-J., Jiang, K., Zhou, Q.-Q., Dong, L., Chen, Y.-C.* Amine-N-Heterocyclic Carbene Cascade Catalysis for the Asymmetric Synthesis of Fused Indane Derivatives with Multiple Chiral Centres. Chem. Commun. 2013, 49, 5892-5894. Jia, Z.-J., Zhou, Q., Zhou, Q.-Q., Chen, P.-Q., Chen, Y.-C.* exo-Selective Asymmetric Diels–Alder Reaction of 2,4-Dienals and Nitroalkenes by Trienamine Catalysis. Angew. Chem., Int. Ed. 2011, 50, 8638-8641. Jia, Z.-J., Jiang, H., Li, J.-L., Gschwend, B., Li, Q.-Z., Yin, X., Grouleff, J., Chen, Y.-C.,* Jørgensen, K. A.* Trienamines in Asymmetric Organocatalysis: Diels−Alder and Tandem Reactions. J. Am. Chem. Soc. 2011, 133, 5053-5061. Jiang, K., Jia, Z.-J., Yin, X., Wu, L., Chen, Y.-C.* Asymmetric Quadruple Aminocatalytic Domino Reactions to Fused Carbocycles Incorporating a Spirooxindole Motif. Org. Lett. 2010, 12, 2766-2769. Jiang, K., Jia, Z.-J., Chen, S., Wu, L., Chen, Y.-C.* Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation. Chem. Eur. J. 2010, 16, 2852-2856. Xiong, X.-F., Jia, Z.-J., Du, W., Jiang, K., Liu, T.-Y., Chen, Y.-C.* Merging Chiral Organocatalysts: Enantio- and Diastereoselective Direct Vinylogous Mannich Reaction of Alkylimines. Chem. Commun. 2009, 6994-6996. Narayan, R., Potowski, M., Jia, Z.-J., Antonchick, A. P.,* Waldmann, H.* Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis. Acc. Chem. Res. 2014, 47, 1296-1310.