罗成 - 中国科学院上海药物研究所 -

个人简介

教育经历： 9/2001-7/2004 中国科学院上海药物研究所有机化学博士 9/1998-7/2001 复旦大学化学系物理化学硕士 9/1990-7/1994 福州大学化学系化学（结构化学）学士工作经历 10/2012-至今中国科学院上海药物研究所，研究员，博导，药物设计与化学生物学 10/2008-10/2012 中国科学院上海药物研究所，副研究员，硕导，药物设计与化学生物学 3/2008-10/2008 中国科学院上海药物研究所，助理研究员，药物设计与化学生物学 9/2005-3/2008 宾夕法尼亚大学Wistar研究所Ronen Marmorstein Lab，博士后，表观遗传学和化学生物学 7/2004-9/2005 中国科学院上海药物研究所，助理研究员，药物设计 10/1994-5/1998 福州抗生素集团有限公司质量检测部，助理工程师，生物检测

研究领域

药物设计和药物化学生物学。运用包括靶标发现、计算机辅助药物设计、分子动力学模拟、生物信息学等理论模拟方法为指导，结合包括生物化学、结构生物学和药物化学生物学等多学科交叉手段，开展包括表观遗传修饰酶和重要蛋白-蛋白相互作用的新靶标、新机制的创新药物及其作用机理研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Lulu Hu#, Junyan Lu#, Jingdong Cheng#, Qinhui Rao, Ze Li, Haifeng Hou, Zhiyong Lou, Lei Zhang, Wei Li, Wei Gong, Mengjie Liu, Chang Sun, Xiaotong Yin, Jie Li, Xiangshi Tan, Pengcheng Wang, Yinsheng Wang, Dong Fang, Qiang Cui, Pengyuan Yang, Chuan He, Hualiang Jiang, Cheng Luo* and Yanhui Xu*, Structural Insight into Substrate Preference for TET-mediated Oxidation. Nature 2015;527(7576):118-22. Jing Wang#, Cheng Luo#（共同第一）, Changliang Shan#, Qiancheng You#, Junyan Lu Shannon Elf, Yu Zhou, Yi Wen, Yuxin Xie, Jan L Vinkenborg, Jun Fan, Heebum Kang, Dali Han, Jason Karpus, Shijie Chen, Shisheng Ouyang, Chihao Luan, Naixia Zhang, Maarten Merkx, Hong Liu, Jing Chen*, Hualiang Jiang*, Chuan He*, Inhibition of human copper trafficking significantly attenuates tumor growth. Nature Chem 2015; 7(12):968-79. Junyan Lu, Chenxiao Jianga, Xiaojing Lia, Lizhi Jiang, Zengxia Li, Tilman Schneider-Poetsch, Kunqian Yu, Jun O. Liu, Hualiang Jiang, Cheng Luo*, Yongjun Dang*. The Inter-domain Linker of eIF4AI Regulates ATP Hydrolysis Coupled Duplex Unwinding, Nucleic Acids Res 2015;. pii: gkv1033. Fanwang Meng, Sufang Cheng, Hong Ding, Shien Liu, Ying Liu, Kongkai Zhu, Shijie Chen, Junyan Lu, Yiqian Xie, Linjuan Li, Rongfeng Liu, Zhe Shi, Yu Zhou, Yu-Chih Liu, Mingyue Zheng, Hualiang Jiang, Wencong Lu*, Hong Liu*, and Cheng Luo*. Discovery and optimization of novel, selective histone methyltransferase SET7 inhibitors by pharmacophore- and docking-based virtual screening. J Med Chem, 2015; 58(20):8166-81. Xiangqian Kong, Jian Liu, Lianchun Li, Liyan Yue, Lihong Zhang, Hualiang Jiang, Xin Xie*, Cheng Luo*, Functional Interplay Between the RK motif and Linker Segment Dictates Oct4-DNA Recognition, Nucleic Acids Res 2015;43(9):4381-92. Yue Huang, Jingli Yan, Qi Li, Jiafei Li, Shouzhe Gong, Hu Zhou, Jianhua Gan, Hualiang Jiang, Gui-Fang Jia*, Cheng Luo*, and Cai-Guang Yang* Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acid Res 2015; 43(1):373-84. Xiangqian Kong, Limin Chen, Lianying Jiao, Xiangrui Jiang, Fulin Lian, Junyan Lu, Kongkai Zhu, Daohai Du, Jingqiu Liu, Hong Ding, Naixia Zhang, Jingshan Shen, Mingyue Zheng, Kaixian Chen, Xin Liu, Hualiang Jiang and Cheng Luo*. Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex 2. J Med Chem, 2014; 57:9512-21. Shijie Chen, Yulan Wang, Wen Zhou, Shanshan Li, Jianlong Peng, Zhe Shi, Junchi Hu, Yu-Chih Liu, Hong Ding, Yijyun Lin, Linjuan Li, Sufang Cheng, Jingqiu Liu, Tao Lu, Hualiang Jiang, Bo Liu*, Mingyue Zheng* and Cheng Luo*. Identifying Novel Selective Non-Nucleoside DNA Methyltransferase 1 Inhibitors through Docking-Based Virtual Screening. J Med Chem, 2014;57,9028-41. Jie Zhang, Hongchuan Liu, Kongkai Zhu, Shouzhe Gong, Shaynoor Dramsi, Ya-Ting Wang, Jiafei Li, Feifei Chen, Ruihan Zhang, Lu Zhou, Lefu Lan, Hualiang Jiang, Olaf Schneewind*, Cheng Luo*, Cai-Guang Yang*. Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase. P Natl Acad Sci 2014;111(37):13517-22. Yifan Jiang, Junyan Lu, Yaping Wang, Feng Zeng, Huiyuan Wang, Huige Peng, Min Huang, Hualiang Jiang, Cheng Luo* and Yongzhuo Huang*. Molecular Dynamic Simulation-driven Design of Protease-responsive Probe for in vivo Tumor Imaging. Adv Mater 2014;26(48):8174-8.