孙华冰 - 天津医科大学

个人简介

教育背景 2010年9月–2015年5月美国威斯康星大学密尔沃基分校，化学专业，博士学位 2007年9月–2010年7月南开大学，有机化学专业，硕士学位 2003年9月–2007年7月天津科技大学，应用化学专业，学士学位工作经历 2019年11月–今天津医科大学药学院，教授 2016年1月–2019年6月美国霍普金斯大学，博士后 2015年8月–2016年1月美国威斯康星大学密尔沃基分校，教员助理

近期论文

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X. Yan, Y. Gao, H. Liu, X. Qiao, C. Xie, Q. Li, W. Gao, H. Sun*, J. Xu*. A novel double target fluorescence probe for Al3+/Mg2+ detection with distinctively different responses and its applications in cell imaging. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 261, 120067. H. Fan, H. Sun, Q. Zhang, X. Peng*. Photoinduced DNA Interstrand Cross‐Linking by 1, 1′‐Biphenyl Analogues: Substituents and Leaving Groups Combine to Determine the Efficiency of Cross‐Linker. Chem. Eur. J. 2021, 27, 5215-5224. A. Korman+, H. Sun+, B. Hua, H. Yang, J. N. Capilato, R. Paul, S. Panja, T. Ha, M. M. Greenberg*, S. A. Woodson*. Light-Controlled Twister Ribozyme with Single-Molecule Detection Resolves RNA Function in Time and Space. Proc. Natl. Acad. Sci. USA, 2020, 117, 12080-12086. H. Sun, L. Zheng, K. Yang, M. M. Greenberg*. Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles. J. Am. Chem. Soc. 2019, 141, 10154-10158. H. Fan+, H. Sun+, M. M. Haque, X. Peng*. Effect of Triazole-Modified Thymidines on DNA and RNA Duplex Stability. ACS Omega, 2019, 4, 5107-5116. K. Yang, H. Sun, L. Lowder, S. Varadarajan*, M. M. Greenberg*. Reactivity of N3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles. Chem. Res. Toxicol. 2019, 32, 2118-2124. H. Sun+, L. Zheng+, M. M. Greenberg*. Independent Generation of Reactive Intermediates Leads to an Alternative Mechanism for Strand Damage Induced by Hole Transfer in Poly(dA-T) Sequences. J. Am. Chem.Soc. 2018, 140, 11308-11316. H. Fan, H. Sun, X. Peng*. Substituents Have a Large Effect on Photochemical Generation of Benzyl Cations and DNA Cross‐Linking. Chem. Eur. J. 2018, 24, 7671-7682. W. Chen+, H. Fan+, K. Balakrishnan, Y. Wang, H. Sun, Y. Fan, V. Gandhi, L. A. Arnold, X. Peng*. Discovery and Optimization of Novel Hydrogen Peroxide Activated Aromatic Nitrogen Mustard Derivatives as Highly Potent Anticancer Agents. J. Med. Chem. 2018, 61, 9132-9145. H. Sun, M. L. Taverna Porro, M. M. Greenberg*. Independent Generation and Reactivity of Thymidine Radical Cations. J. Org. Chem. 2017, 82, 11072-11083. Y. Wang+, H. Fan+, K. Balakrishnan, Z. Lin, S. Cao, W. Chen, Y. Fan, Q. A. Guthrie, H. Sun, K. A. Teske, V.Gandhi, L. A. Arnold, X. Peng*. Hydrogen Peroxide Activated Quinone Methide Precursors with Enhanced DNA Cross-Linking Capability and Cytotoxicity towards Cancer Cells. E. J. Med. Chem. 2017, 133, 197-207. H. Sun+, H. Fan+, H. Eom, X. Peng*. Coumarin-Induced DNA Ligation, Rearrangement to DNA Interstrand Crosslinks, and Photorelease of Coumarin Moiety. ChemBioChem, 2016, 17, 2046-2053. Y. Han, W. Chen, Y. Kuang, H. Sun, Z. Wang, X. Peng*. UV-Induced DNA Interstrand Cross-Linking and Direct Strand Breaks from a New Type of Binitroimidazole Analogue. Chem. Res. Toxicol. 2015, 28, 919-926. H. Sun, H. Fan, X. Peng*. Quantitative DNA interstrand cross-link formation by coumarin and thymine:structure determination, sequence effect, and fluorescence detection. J. Org. Chem. 2014, 79, 11359-11369. M. M. Haque, H. Sun, S. Liu, Y. Wang, X. Peng*. Photoswitchable Formation of a DNA Interstrand Cross-Link by a Coumarin‐Modified Nucleotide. Angew. Chem. Int. Ed. 2014, 53, 7001-7005. J. Zhao, H. Sun, L. Liu, W. Chang, J. Li*. Synthesis, Characterization and Potential Electrochemical Properties of Novel Mn-Re Dinuclear Complexes Containing N-Heterocyclic Carbene-carbon Disulfide Ligands.Chem. J. Chinese U. 2014, 35, 68-74. H. Sun, X. Peng*. Template-Directed Fluorogenic Oligonucleotide Ligation using “Click” Chemistry:Detection of Single Nucleotide Polymorphism in the Human p53 Tumor Suppressor Gene. Bioconjugate Chem.2013, 24, 1226-1234. Y. Kuang, H. Sun, J. C. Blain, X. Peng*. Hypoxia-Selective DNA Interstrand Cross-Link Formation by Two Modified Nucleosides. Chem. Eur. J. 2012, 18, 12609-12613.