Lennox, Alastair J. J. - University of Bristol

个人简介

Career Summary 2022 – Present Royal Society University Research Fellow and Proleptic Associate Professor University of Bristol 2019 – 2022 Royal Society University Research Fellow and Proleptic Lecturer University of Bristol 2018 – 2019 Royal Society University Research Fellow University of Bristol 2015 – 2017 Postdoctoral Research Fellow University of Wisconsin, Madison, USA Prof. Shannon S Stahl Development of electrochemical catalytic reactions in collaboration with AbbVie 2014 – 2015 Alexander von Humboldt Fellow Leibniz Institute for Catalysis (LIKAT), Rostock, Germany Prof. Matthias Beller Homo- and heterogeneous photocatalytic water reduction Visiting researcher: Luo group, ZJUT, Hangzhou, China 2008 – 2012 PhD University of Bristol Prof Guy Lloyd-Jones FRS Thesis: Organotrifluoroborate Preparation, Coupling and Hydrolysis 2004 – 2008 MChem University of Manchester Chemistry with Studies in North America (UCLA)

研究领域

The PI of our group is interested in fundamental reactivity and mechanism in organic chemistry, and exploiting modern innovative technologies, such electrochemistry, to develop new synthetic reactions with a strong focus on sustainability and practicality.

近期论文

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Benzylic C(sp3)–H fluorination Alexander P. Atkins, Alice C. Dean, Alastair J. J. Lennox* Beilstein J. Org. Chem. 2024, 20, 1527–1547. Diastereodivergent nucleophile–nucleophile alkene chlorofluorination Sayad Doobary, Andrew J. D. Lacey, Stephen G. Sweeting, Sarah B. Coppock, Henry P. Caldora, Darren L. Poole, Alastair J. J. Lennox* Nat. Chem. (2024). https://doi.org/10.1038/s41557-024-01561-6 Silver-Catalyzed (Z)-β-Fluoro-vinyl Iodonium Salts from Alkynes: Efficient and Selective Syntheses of Z-Monofluoroalkenes Alexi T. Sedikides, Alastair J. J. Lennox* J. Am. Chem. Soc. 2024, 146, 23, 15672–15680 Bromide-Mediated Silane Oxidation: A Practical Counter-Electrode Process for Nonaqueous Deep Reductive Electrosynthesis Mickael E. Avanthay, Oliver H. Goodrich, David Tiemessen, Catherine M. Alder, Michael W. George, Alastair J. J. Lennox* JACS Au, 2024, 4, 6, 2220–2227 Policy briefing on “Defossilising the chemical industry”.Royal Society, Co-written by Alastair J. J. Lennox* https://royalsociety.org/news-resources/projects/defossilising-chemicals/ Alkene 1,3-Difluorination via Transient Oxonium Intermediates Alice C. Dean. E. Harvey Randle, Andrew J. D. Lacey, Guiherme A. Marczak Giorio, Sayad Doobary, Benjamin D. Cons, Alastair J. J. Lennox* Angew. Chem. Int. Ed.2024, e202404666 A Stoichiometric Haloform Coupling for Ester Synthesis with Secondary Alcohols Bert C. Rowett, Stephen G. Sweeting, David Heard, Alastair J. J. Lennox* Angew. Chem. Int. Ed. 2024,63, e2024005 Application of Pulsed Electrolysis in Organic Electrosynthesis A. P. Atkins, A. J. J. Lennox* Curr. Opin. Electrochem., 2024, article 101441 Electrochemical Benzylic C(sp3)-H Direct Amidation A. Choi, O. H. Goodrich, A. P. Atkins, M. D. Edwards, D. Tiemessen, M. W. George, A. J. J. Lennox* Org. Lett. 2024, 26, 3, 653–657 Pulsed electrolysis: enhancing primary benzylic C(sp3)–H nucleophilic fluorination A. P. Atkins, A. K. Chaturvedi, J. A. Tate, A. J. J. Lennox* Organic Chemistry Frontiers, 2024, 11, 802 - 808 Electrochemical Synthesis of Biaryls by Reductive Extrusion from N,N'-diarylureas E. Stammers, C. Parsons, J. Clayden*, A. J. J. Lennox* Nature Communications, 2023, 14, Article number: 4561 Bromide-Mediated Silane Oxidation: A Convenient and Practical Counter-Electrode Process for Undivided Electrochemical Reductions M. E. Avanthay, O. Goodrich, M. George, A. J. J. Lennox ChemRxiv Preprint, 10.26434/chemrxiv-2023-w3l2v Electronically Ambivalent Hydrodefluorination of Aryl-CF3 groups enabled by Electrochemical Deep-Reduction on a Ni Cathode J. R. Box, M. E. Avanthay, D. L. Poole and A. J. J. Lennox Angew. Chem. Int. Ed., 2023, 62, 12, e202218195 Electrochemical Benzylic C(sp3)–H Acyloxylation A. P. Atkins, A. C. Rowett, D. M. Heard, J. A. Tate, and A. J. J. Lennox Org. Lett., 2022, 24, 28, 5105-5108 The “Ex-cell” Approach to Organic Electrosynthesis S. B. Coppock and A. J. J. Lennox Curr. Opin. Electrochem., 2022, 35, 101069 Intramolecular Alkene Fluoroarylation of Phenolic Ethers Enabled by Electrochemically Generated Iodane S. Doobary, D. L. Poole and A. J. J. Lennox J. Org. Chem., 2021, 86, 22, 16095-16103 Electrochemistry in Natural Product Synthesis K. Lam, M. C. Leech and A. J. J. Lennox Science of Synthesis: Electrochemistry in Organic Synthesis, Ackermann, L., Ed.; Thieme: Stuttgart, (2021); Vol. 1, p 435-480 Daisy-Chaining Photo- and Thermal Chemistry: Multistep Continuous Flow Synthesis of Visible-Light-Mediated Photochemistry with a High-Temperature Cascade Reaction L. D. Elliot, K.I. Booker-Milburn and A. J. J. Lennox*, Org. Process. Res. Dev. 2021, 255, 8, 1943-1949 Direct Electrochemical Hydrodefluorination of Trifluoromethylketones Enabled by Non-Protic Conditions J. R. Box, A. P. Atkins and A. J. J. Lennox*, Chem. Sci. 2021, 12, 10252-10258 3D Printed Reactionware for Synthetic Electrochemical Reactions with Hydrogen Fluoride Reagents D. M. Heard, S. Doobary and A. J. J. Lennox*, ChemElectroChem, 2021, 8, 11, 2070-2074 Dichloromeldrum’s Acid (DiCMA): A Practical and Green Amine Dichloroacetylation Reagent D. M. Heard and A. J. J. Lennox*, Org. Lett. 2021, 23, 9, 3368-3372 Identifying Palladium Culprits in Amine Catalysis M. Avanthay, R. Bedford, C. Begg, D. Böse, J. Clayden, S. Davis, J. Eloi, G. P. Goryunov, I. V. Hartung, J. Heeley, K. A. Khaikin, M. Kitching, J. Krieger, P. S. Kulyabin, A. J. J. Lennox, R. Nolla-Saltiel, N. E. Pridmore, B. J. S. Rowsell, H. A. Sparkes, D. V. Uborsky, A. Z. Voskoboynikov, M. Walsh, H. J. Wilkinson Nat. Catal., 2021, DOI: 10.1038/s41929-021-00710-1 Electrode Materials in Modern Organic Electrochemistry D. M. Heard and A. J. J. Lennox*, Angew. Chem. Int. Ed. 2020, 59, 43, 18866-18884 Alkene Vicinal Difluorination: From Fluorine gas to more Favoured conditions S. Doobary and A. J. J. Lennox* Synlett, 2020, 31, 1333-1342 Synthesis, Stability and Biological Studies of Fluorinated Analogues of Thromboxane A2 C. Jing, S. Mallah, E. Kriemen, S. H. Bennett, V. Fasano, I. Hers,* A. J. J. Lennox,* and V. K. Aggarwal* ACS Central Science, 2020, 6, 995-1000 Minimal Manual Input D. M. Heard & A. J. J. Lennox* Nature Chemistry, 2020, 12, 113-114 Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron‐rich Substrates S. Doobary, A. T. Sedikides, H. P. Caldora, D. L. Poole, A. J. J. Lennox* Angew. Chem. Int. Ed., 2020, 59, 1155-1160 Meisenheimer Complexes in SNAr Reactions: Intermediates or Transition States? A. J. J. Lennox* Angew. Chem. Int. Ed., 2018, 57, 14686–14688 Heteroleptic copper(I) photosensitizers with carbazole-substituted phenanthroline ligands: Synthesis, photophysical properties and application to photocatalytic H2 generation Z.-J. Yu, H. Chen, A. J. J. Lennox, L.-J. Yan, X.-F. Liu, D.-D. Xu, F. Chen, L.-X. Xu, Y. Li, Q.-A. Wu, S.-P. Luo Dye. Pigment., 2019, 162, 771–775