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个人简介

教育背景 2008.09~2013.07 北京大学 有机化学 博士(导师:席振峰院士,张文雄教授) 2004.09~2008.06 中国农业大学 化学 学士(导师:施章杰教授) 工作经历 2019.10至今 中国海洋大学 副教授 2017.11~2019.08 加拿大西蒙弗雷泽大学(SFU) 博士后 导师:Robert Britton 2013.09~2016.03 瑞士洛桑联邦理工学院(EPFL)博士后 导师:JiepingZhu 学术兼职 担任Org. Lett., Chem. Commun., J. Org. Chem., Chin. Chem. Lett.等国际期刊审稿人。 荣誉奖励 1. 2020 山东省“泰山学者”青年专家 2. 2014 欧盟MARIE CURIE Fellowship 3. 2013北京大学化学与分子工程学院优秀博士毕业论文 4. 2013 陶氏化学全球可持续发展创新奖

研究领域

1. 类天然产物和药物优势骨架合成的新方法研究 2. 含氮活性分子骨架的合成及其导向的药物化学 3. 海洋天然产物及其类似物的合成

近期论文

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Xinyu Zhang, Yuan Pan, Tao Liu, Yang Wang.*A facile synthesis of 1,3,4-benzotriazepinones from isatoic anhydrides and hydrazonyl chlorides. J. Org. Chem.2023, Accepted. (IF: 4.198) Hao Dong, Yongxing Zhang, Xiaochen Tian, Ruochen Pang, Weiwu Ren, Yang Wang.*Catalyst-free and oxidant-free tandem aza-Mannich/cyclization/aromatization of C,N-cyclic azomethine imines with enamides: facile synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. Green Chem.2022, 24, 5508. (IF: 11.034) Lesong Li, Tao Liu, Weiwu Ren, Yang Wang.*Catalyst-free and atom-economical [4+3] cycloaddition of azadienes with cyclic azomethine imines for facile synthesis of 1,2,4-triazepines. Green Synth. Catal.2022, DOI:10.1016/j.gresc.2022.10.010. Fengbiao Luo, Hao Dong, Weiwu Ren,*Yang Wang.*Organocatalytic asymmetric synthesis of tetrahydroquinolines from ortho-aminophenyl para-quinone methides. Org. Lett. 2022, 24, 7727. (IF: 6.072) Yuan Pan, Weiwu Ren,*Zhanhao Zhang, Fengbiao Luo, Xiaohan Hou, Xiaoyang Li, Yun-Fang Yang, Yang Wang.*Tandem 1,6-addition/cyclopropanation/rearrangement reaction of vinylogous para-quinone methides with 3-chlorooxindoles: construction of vicinal quaternary carbon centers.Org. Chem. Front.2022, 9, 3697. (IF: 5.456) Xiaochen Tian, Yongxing Zhang, Hao Dong, Weiwu Ren,*Yang Wang.*Asymmetric α‑regioselective [3 + 2] annulation of Morita−Baylis−Hillman carbonates: construction of three contiguous stereocenters with vicinal quaternary carbon centers. J. Org. Chem.2022, 87, 9593. (IF: 4.198) Xiaochen Tian, Yongxing Zhang, Weiwu Ren, Yang Wang.*Synthesis of functionalized 3,2'-pyrrolidinyl spirooxindoles via domino 1,6-addition/annulation reactions of para-quinone methides and3-chlorooxindoles. Org. Chem. Front. 2022, 9, 615. (IF: 5.456) Lesong Li, Tao Liu, Xiaoli Zhang, Xiaohan Hou, Hao Dong, Xiaoyang Li, Weiwu Ren, Yang Wang.*Catalyst-free and atom-economical 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines: facile synthesis of isoquinoline-fused spirocycles. Green Synth. Catal.2022,2, 69. Xiaochen Tian, Xiaoli Zhang, Xiaohan Hou, Weiwu Ren, Xiaoyang Li, Fei Zhao, Houchao Tao, Yang Wang.* Formal [4+1] cyclization of ortho- or para-quinone methides with3-chlorooxindoles: synthesis of 3,2’-tetrahydrofuryl spirooxindoles. Asian J. Org. Chem.2021, 10, 2385. (IF: 3.116) Roger A. Ashmus, Yang Wang (co-first author), Manuel González-Cuesta, Dustin T. King,Ben Tiet, Pierre-André Gilormini, a José M. García Fernández, Carmen Ortiz Mellet, Robert Britton,* David J. Vocadlo.*Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA). Org. Biomol. Chem.2021, 19, 8057. (IF: 3.890) Michael Meanwell, Steven M. Silverman, Johannes Lehmann, Bharanishashank Adluri, Yang Wang, Ryan Cohen, Louis-Charles Campeau, Robert Britton.* A short de novo synthesis of nucleoside analogs. Science2020, 369, 725. (IF: 63.714) Yang Wang,*Wen-Xiong Zhang,* Zhenfeng Xi. Carbodiimide-based synthesis of N-heterocycles: moving from two classical reactive sites to chemical bond breaking/forming reaction. Chem. Soc. Rev.2020,49, 5810. (IF: 60.615) Yang Wang,Qian Wang, Jieping Zhu.* Organocatalytic nucleophilic addition of hydrazones to imines: synthesis of enantioenriched vicinal diamines. Angew. Chem. Int. Ed. 2017, 56, 5612-5615.(IF: 16.823) Yang Wang, Qian Wang, Jieping Zhu.* Chiral phosphoric acid-catalyzed enantioselective formal [3+2] cycloaddition of azomethine imines with enecarbamates. Chem. Eur. J. 2016, 22, 8084-8088. (IF: 5.020) Yang Wang, Fei Zhao, Yue Chi, Wen-Xiong Zhang,* Zhenfeng Xi.Substituent-controlled selective synthesis of N-acyl 2-aminothiazoles by intramolecular zwitterion-mediated C−N bond cleavage. J. Org. Chem. 2014, 79, 11146-11154.(IF: 4.198) Yang Wang, Fei Zhao, Yi Zhou, Yue Chi, Zitao Wang, Wen-Xiong Zhang,* Zhenfeng Xi.Mechanistic Study on the Cleavage and Reorganization of C(sp3)–H and C=N Bonds in Carbodiimides: Synthesis of 1,2-Dihydrothiopyrimidines and 2,3-Dihydropyrimidinthiones via Four-Component Coupling. Chem. Eur. J. 2013, 19, 10643-10654.(IF: 5.020) Yang Wang, Yue Chi, Fei Zhao, Wen-Xiong Zhang,* Zhenfeng Xi. Synthesis, characterization, and reactivity of N-acyl chloroformamidines: useful building blocks for construction of N-acyl-substituted 1,1-diaminoethylenes, amidines, ureas, and thioureas. Synthesis 2013, 45, 347-354. (IF: 2.969) Yang Wang,Yue Chi, Wen-Xiong Zhang,* Zhenfeng Xi.*Regioselective ring expansion of 2,4-diiminoazetidines via cleavage of C–N and C(sp3)-H bonds: efficient construction of 2,3-dihydropyrimidinesulfonamides.J. Am. Chem. Soc. 2012, 134, 2926-2929. (IF: 16.383)19. Yang Wang,Wen-Xiong Zhang,* Zitao Wang, Zhenfeng Xi.*Procedure-controlled selective synthesis of 5-acyl-2-iminothiazolines and their selenium and tellurium derivatives by convergent tandem annulation.Angew. Chem., Int. Ed. 2011, 50, 8122-8126.(IF: 16.823)

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