个人简介

Dr. Chad A. Mirkin is the Director of the International Institute for Nanotechnology and the George B. Rathmann Prof. of Chemistry, Prof. of Chemical and Biological Engineering, Prof. of Biomedical Engineering, Prof. of Materials Science & Engineering, and Prof. of Medicine at Northwestern University. He is a chemist and a world-renowned nanoscience expert, who is known for his discovery and development of spherical nucleic acids (SNAs) and SNA-based biodetection and therapeutic schemes, the invention of Dip-Pen Nanolithography (DPN) and related cantilever-free nanopatterning methodologies, On-Wire Lithography (OWL), Co-Axial Lithography (COAL), and contributions to supramolecular chemistry and nanoparticle synthesis. He is the author of over 850 manuscripts and over 1,200 patent applications worldwide (over 400 issued), and the founder of multiple companies, including Nanosphere, AuraSense, TERA-print, Azul 3D, MattIQ, and Flashpoint Therapeutics. Mirkin holds a B.S. degree from Dickinson College (1986, elected into Phi Beta Kappa) and a Ph.D. degree in Chemistry from the Penn. State Univ. (1989). He was an NSF Postdoctoral Fellow at the MIT prior to becoming a professor at Northwestern Univ. in 1991.

研究领域

Organic, Synthetic, Bio-Organic, Chemical Biology, Polymer, Inorganic, Organometallics, Bioinorganic, Physical, Analytical, Energy Related, Biophysical, Bio-analytical, Catalysis, Energy and Environmental, Nanoscience, Materials

The Mirkin Research Group focuses on developing methods for controlling the architecture of molecules and materials on the 1 – 100 nm length scale, understanding their fundamental properties, and utilizing such structures to develop novel tools that can be applied in the areas of chemical and biological sensing, gene regulation, immunomodulation, lithography, catalysis, optics, and energy generation, storage, and conversion. The Mirkin Research Group has pioneered the use of nanoparticle-biomolecule conjugates as synthons in materials science and the development of many nanoparticle-based extra- and intracellular biodiagnostic and therapeutic tools.

近期论文

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Thaxton, C. S.; Mirkin, C. A. “Plasmon Coupling Measures Up,” Nature Biotech, 2005, 23, 681-682, doi: 10.1038/nbt0605-681. Oh, M.; Mirkin, C. A. “Chemically Tailorable Colloidal Particles From Infinite Coordination Polymers,” Nature, 2005, 438, 651-654, doi: 10.1038/nature04191. Hill, H. D.; Mirkin, C. A. “The Bio-Barcode Assay for the Detection of Protein and Nucleic Acid Targets Utilizing Dithiothreitol Induced Ligand Exchange,” Nature Protocols, 2006, 1, 324-336, doi: 10.1038/nprot.2006.51. Dipp, M.; Westphal, C.; Mirkin, C. A.; Baker, J.; Harper, T.; Harris, C. “Keeping It Real with Investors,” Nature Biotechnology, 2006, 24, 133-135, doi: 10.1038/bioent899. Salaita, K.; Wang, Y. H.; Mirkin, C. A. “Applications of Dip-Pen Nanolithography,” Nature Nanotech., 2007, 2, 145-155, doi: 10.1038/nnano.2007.39. Park, S. Y.; Lytton-Jean, A. K. R.; Lee, B.; Weigand, S.; Schatz, G. C.; Mirkin, C. A. “DNA-Programmable Nanoparticle Crystallization,” Nature, 2008, 451, 553-556, doi: 10.1038/nature06508. Giljohann, D. A.; Mirkin, C. A. “Tiny Tiles, Tiny Targets,” Nature Biotechnol., 2008, 26, 299-300, doi: 10.1038/nbt0308-299. Banholzer, M. J.; Qin, L. D.; Millstone, J. E.; Osberg, K. D.; Mirkin, C. A. “On-Wire Lithography: Synthesis, Encoding, and Biological Applications,” Nature Protocols, 2009, 4, 838-848, doi: 10.1038/nprot.2009.52, PMCID: PMC3918426. Braunschweig, A. B.; Huo, F. W.; Mirkin, C. A. “Molecular Printing,” Nature Chem., 2009, 1, 353-358, doi: 10.1038/nchem.258, PMCID: PMC3936963. Giljohann, D. A. and Mirkin, C. A. “Drivers of Biodiagnostic Development,” Nature, 2009, 462, 461-464, doi: 10.1038/nature08605, PMCID: PMC3936986. Huo, F.; Zheng, G.; Liao, X.; Giam, L. R.; Chai, J.; Chen, X.; Shim, W.; Mirkin, C. A. “Beam Pen Lithography,” Nature Nanotechnol., 2010, 5, 637-640, doi: 10.1038/nnano.2010.161. Jones, M. R.; Macfarlane, R. J.; Lee, B.; Zhang, J.; Young, K. L.; Senesi, A. J.; Mirkin, C. A. “DNA-Nanoparticle Superlattices Formed From Anisotropic Building Blocks,” Nature Mater., 2010, 9, 913-917, doi: 10.1038/nmat2870. Shim, W.; Braunschweig, A. B.; Liao, X.; Chai, J.; Lim, J. K.; Zheng, G.; Mirkin, C. A. “Hard-Tip, Soft-Spring Lithography,” Nature, 2011, 469, 516-520, doi: 10.1038/nature09697. Spokoyny, A. M.; Machan, C. W.; Clingerman, D. J.; Rosen, M. S.; Wiester, M. J.; Kennedy, R. D.; Stern, C. L.; Sarjeant, A. A.; Mirkin, C. A. “A Coordination Chemistry Dichotomy for Icosahedral Carborane-Based Ligands,” Nature Chem., 2011, 3, 590-596, doi: 10.1038/nchem.1088. Huang, X.; Li, S. Z.; Huang, Y. Z.; Wu, S. X.; Zhou, X. Z.; Li, S. Z.; Gan, C. L.; Boey, F.; Mirkin, C. A.; Zhang, H. “Synthesis of Hexagonal Close-Packed Gold Nanostructures,” Nature Commun., 2011, 2, 292, doi: 10.1038/ncomms1291. Jones, M. R.; Mirkin, C. A. “Self-Assembly Gets New Direction,” Nature, 2012, 491, 42-43, doi: 10.1038/491042a. Auyeung, E.; Cutler, J. I.; Macfarlane, R. J.; Jones, M. R.; Wu, J.; Liu, G.; Zhang, K.; Osberg, K. D.; Mirkin, C. A. “Synthetically Programmable Nanoparticle Superlattices Using a Hollow Three-Dimensional Spacer Approach,” Nature Nanotech., 2012, 7, 24-28, doi: 10.1038/nnano.2011.222. Zhang, C.; Macfarlane, R. J.; Young, K. L.; Choi, C. H. J.; Hao, L.; Auyeung, E.; Liu, G. Zhou, X.; Mirkin, C. A. “A General Approach to DNA-Programmable Atom Equivalents,” Nature Materials, 2013, 12, 741-746, doi: 10.1038/nmat3647. Liao, X.; Brown, K. A.; Schmucker, A. L.; Liu, G.; He, S.; Shim, W.; Mirkin, C. A. “Desktop Nanofabrication with Massively Multiplexed Beam Pen Lithography,” Nature Comm., 2013, 4, 2103, doi: 10.1038/ncomms3103, PMCID: PMC3807695. Liu, Z.; Frasconi, M.; Lei, J.; Brown, Z. J.; Zhu, Z.; Cao, D.; Iehl, J.; Liu, G.; Fahrenbach, A.; Botros, Y. Y.; Farha, O.; Hupp, J.; Mirkin, C. A.; Stoddart, J. F. “Selective isolation of gold facilitated by second-sphere coordination with α-cyclodextrin,” Nature Comm., 2013, 4, 1855, doi: 10.1038/ncomms2891, PMCID: PMC3674257. Eichelsdoerfer, D.J.; Liao, X.; Cabezas, M.D.; Morris, W.; Radha, B.; Brown, K.A.; Giam, L.R.; Braunschweig, A.B.; Mirkin, C.A. “Large-Area Molecular Patterning with Polymer Pen Lithography,” Nature Protocols, 2013, 8, 2548-2560, doi: 10.1038/nprot.2013.159. Auyeung, E.; Li, T.I.N.G; Senesi, A.J.; Schmucker, A.L.; Pals, B.C.; Olvera de la Cruz, M.; Mirkin, C.A. “DNA-mediated nanoparticle crystallization into Wulff polyhedra,” Nature, 2014, 505, 73-77, doi: 10.1038/nature12739. Kelley, S. O.; Mirkin, C. A.; Walt, D. R.; Ismagilov, R. F.; Toner, M.; Sargent, E. H. “Advancing the Speed, Sensitivity and Accuracy of Biomolecular Detection using Multi-Length-Scale Engineering,” Nature Nanotechnology, 2014, 9, 969-980, doi: 10.1038/nnano.2014.261, PMCID: PMC4472305. Lifschitz, A. M.; Young, R. M.; Mendez-Arroyo, J.; Stern, C. L.; McGuirk, C. M.; Wasielewski, M. R.; Mirkin, C. A. “An Allosteric Photoredox Catalyst Inspired by Photosynthetic Machinery,” Nature Communications, 2015, 6, 6541, doi:10.1038/ncomms7541, PMCID: PMC4389231. Ozel, T.; Bourret, G. R.; Mirkin, C. A. “Coaxial Lithography,” Nature Nanotechnology, 2015, 10, 319-324, doi: 10.1038/nnano.2015.33. O’Brien, M. N.; Jones, M. R.; Lee, B.; Mirkin, C. A. “Anisotropic Nanoparticle Complementarity in DNA-Mediated Cocrystallization,” Nature Materials, 2015, 14, 833-839 doi: 10.1038/nmat4293. Ross, M. R.; Ku, J. C.; Vaccarezza, V. M.; Schatz, G. C.; Mirkin, C. A. “Nanoscale Form Dictates Mesoscale Function in Plasmonic DNA-nanoparticle Superlattices,” Nature Nanotechnology, 2015, 10, 453-458, doi: 10.1038/nnano.2015.68. Padmos, J. D.; Personick, M.; Tang, Q.; Duchesne, P.; Jiang, D.; Mirkin, C. A.; Zhang, P. “The Surface Structure of Silver-coated Gold Nanocrystals and Its Influence on Shape Control,” Nature Comm., 2015, 6, 7664, doi: 10.1038/ncomms8664, PMCID: PMC4510708. Brown, K. A.; He, S.; Eichelsdoerfer, D. J.; Huang, M.; Levy, I.; Lee, H.; Ryu, S.; Irvin, P.; Mendez-Arroyo, J.; Eom, C.-B.; Mirkin, C. A.; Levy, J. “Giant Conductivity Switching of LaAIO3/SrTiO3 Heterointerfaces Governed By Surface Protonation,” Nature Communications, 2016, 7, doi: 10.1038/ncomms10681. Seo, S. E.; Girard, M.; Olvera de la Cruz, O.: Mirkin C. A. “Non-equilibrium Anisotropic Colloidal Crystal Growth With DNA,” Nature Communications, 2018, 9, 4558, doi: 10.1038/s41467-018-06982-9. Yeo, D.; Wiraja, C.; Paller, A. S.; Mirkin, C. A.; Xu, C. “Abnormal scar identification with spherical-nucleic-acid technology,” Nature Biomedical Engineering, 2018, 2, 227-238, doi: 10.1038/s41551-018-0218x. Mirkin, C. A.; Petrosko, S. H. “DNA Enters a New Phase,” Nature Nanotechnology (News and Views), 2018, 13, 624-625, doi: 10.1038/s41565-018-0229-5. Laramy, C. R.; O’Brien, M. N.; Mirkin, C. A. “Crystal Engineering with DNA,” Nature Reviews Materials, 2019, 4, 201-224, //doi.org/10.1038/s41578-019-0087-2. Yamankurt, G.; Berns, E. J.; Xue, A.; Lee, A.; Bagheri, N.; Mrksich, M.; Mirkin, C. A. “Exploration of the Nanomedicine-design Space with High-Throughput Screening and Machine Learning,” Nature Biomedical Engineering, 2019, 3, 318-327, doi: 10.1038/s41551-019-0351-1, PMCID: PMC6452897. Nam, K. W.; Park, S. S.; dos Reis, R.; Dravid, V. P.; Kim, H.; Mirkin, C. A.; Stoddart, J. F. “Conductive 2D Metal-Organic Framework for High-Performance Cathodes in Aqueous Rechargeable Zinc Batteries,” Nature Communication, 2019, 10, 4948, doi: 10.1038/s41467-019-12857-4. Mirkin, C. A.; Laramy, C. R.; Skakuj, K. “The Power of Spheres,” Nature, 2019, 576, S3-S7, doi: 10.1038/d41586-019-03713-y. Wang, S; Park, S. S.; Buru, C. T.; Lin, H.; Chen, P.-C.; Roth, E. W.; Farha, O. K.; Mirkin, C. A. “Colloidal Crystal Engineering with Metal-Organic Framework Nanoparticles and DNA,” Nature Communications, 2020, 11, 2495, doi: 10.1038/s41467-020-16339-w. Wang, S; Lee. S.; Du, J. S.; Partridge, B.E; Cheng, H.F; Zhou, W.; Dravid, V.P; Glotzer, S.C.; Mirkin, C. A. “The emergence of valency in colloidal crystals through electron equivalents,” Nature Materials, 2022, https://doi.org/10.1038/s41563-021-01170-5 Swisher, J.H; Jibril, L; Petrosko, S.H; Mirkin, C. A. “Nanoreactors for Particle Synthesis,” Nature Reviews Materials, 2022, https://doi.org/10.1038/s41578-021-00402-z Ebrahimi, S. B.; Samanta, D., Kusmierz, C. D.; Mirkin, C. A. “Protein Transfection Via Spherical Nucleic Acids,” Nature Protocols, 2022, https://doi.org/10.1038/s41596-021-00642-x Lee S, Calcaterra HA, Lee S, Hadibrata W, Lee B, Oh E, Aydin K, Glotzer SC, Mirkin, C. A. “Shape memory in self-adapting colloidal crystals” Nature , 2022, Oct;610(7933):674-679. doi: 10.1038/s41586-022-05232-9 Li Y, Zhou W, Tanriover I, Hadibrata W, Partridge BE, Lin H, Hu X, Lee B, Liu J, Dravid VP, Aydin K, Mirkin CA.. Open Channel metal particle superlattices.” Nature , 2022, Nov;611(7937):695-701. doi: 10.1038/s41586-022-05291-y