Clardy, Jon - Harvard Medical School - Department of Biological Chemistry and Molecular Pharmacology

研究领域

The laboratory focuses on biologically active small molecules, especially those from bacteria and fungi with an overall goal of understanding how small molecules control biological processes. Organizing themes include: 1) function-based discovery of microbially-produced small molecules and their roles in microbial symbioses , 2) function-based discovery of biologically active small molecules using high-throughput screening, 3) genome-based discovery of bacterially-produced small molecules.

近期论文

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Biosynthesis of the Unusual Epoxy Isonitrile-Containing Antibiotics Aerocyanidin and Amycomicin. Authors: Authors: Zheng Z, Clardy J, Liu HW. J Am Chem Soc 2024-07-31 Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra. Authors: Authors: King AM, Zhang Z, Glassey E, Siuti P, Clardy J, Voigt CA. Nat Microbiol 2023-12-01 A Cardiolipin from Muribaculum intestinale Induces Antigen-Specific Cytokine Responses. Authors: Authors: Bang S, Shin YH, Ma X, Park SM, Graham DB, Xavier RJ, Clardy J. J Am Chem Soc 2023-11-01 Revisiting Coley's Toxins: Immunogenic Cardiolipins from Streptococcus pyogenes. Authors: Authors: Shin YH, Bang S, Park SM, Ma X, Cassilly C, Graham D, Xavier R, Clardy J. J Am Chem Soc 2023-10-04 Discovering functional small molecules in the gut microbiome. Authors: Authors: Seyedsayamdost MR, Clardy J. Curr Opin Chem Biol 2023-08-01 Collinsella aerofaciens Produces a pH-Responsive Lipid Immunogen. Authors: Authors: Kwon J, Bae M, Szamosvári D, Cassilly CD, Bolze AS, Jackson DR, Xavier RJ, Clardy J. J Am Chem Soc 2023-03-23 Gut microbiome lipid metabolism and its impact on host physiology. Authors: Authors: Brown EM, Clardy J, Xavier RJ. Cell Host Microbe 2023-02-08 Lyme Disease, Borrelia burgdorferi, and Lipid Immunogens. Authors: Authors: Szamosvári D, Bae M, Bang S, Tusi BK, Cassilly CD, Park SM, Graham DB, Xavier RJ, Clardy J. J Am Chem Soc 2022-02-16 Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus. Authors: Authors: Yan JX, Wu Q, Helfrich EJN, Chevrette MG, Braun DR, Heyman H, Ananiev GE, Rajski SR, Currie CR, Clardy J, Bugni TS. Mar Drugs 2022-01-01 Benefiting from big data in natural products: importance of preserving foundational skills and prioritizing data quality. Authors: Authors: Cech NB, Medema MH, Clardy J. Nat Prod Rep 2021-11-17 Neuronal control of maternal provisioning in response to social cues. Authors: Authors: Wasson JA, Harris G, Keppler-Ross S, Brock TJ, Dar AR, Butcher RA, Fischer SEJ, Kagias K, Clardy J, Zhang Y, Mango SE. SciAdv 2021-08-01 A Machine Learning Bioinformatics Method to Predict Biological Activity from Biosynthetic Gene Clusters. Authors: Authors: Walker AS, Clardy J. J Chem Inf Model 2021-05-27 Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus. Authors: Authors: Henke MT, Brown EM, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J. Proc Natl Acad Sci U S A 2021-05-18 Burkholderia from fungus gardens of fungus-growing ants produce antifungals that inhibit the specialized parasite Escovopsis. Authors: Authors: Francoeur CB, May DS, Thairu MW, Hoang DQ, Panthofer O, Bugni TS, Pupo MT, Clardy J, Pinto-Tomás AA, Currie CR. Appl Environ Microbiol 2021-05-07 Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis. Authors: Authors: Fukuda TTH, Helfrich EJN, Mevers E, Melo WGP, Van Arnam EB, Andes DR, Currie CR, Pupo MT, Clardy J. ACS Cent Sci 2021-02-24 Bacterial diketopiperazines stimulate diatom growth and lipid accumulation. Authors: Authors: Sittmann J, Bae M, Mevers E, Li M, Quinn A, Sriram G, Clardy J, Liu Z. Plant Physiol 2021-02-23 Chemical Exchanges between Multilateral Symbionts. Authors: Authors: Bae M, Mevers E, Pishchany G, Whaley SG, Rock CO, Andes DR, Currie CR, Pupo MT, Clardy J. Org Lett 2021-02-16 Pollen Streptomyces Produce Antibiotic That Inhibits the Honey Bee Pathogen Paenibacillus larvae. Authors: Authors: Grubbs KJ, May DS, Sardina JA, Dermenjian RK, Wyche TP, Pinto-Tomás AA, Clardy J, Currie CR. Front Microbiol 2021-01-01 Plasmalogen Biosynthesis by Anaerobic Bacteria: Identification of a Two-Gene Operon Responsible for Plasmalogen Production in Clostridium perfringens. Authors: Authors: Jackson DR, Cassilly CD, Plichta DR, Vlamakis H, Liu H, Melville SB, Xavier RJ, Clardy J. ACS Chem Biol 2020-12-22 Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways. Authors: Authors: Ye L, Bae M, Cassilly CD, Jabba SV, Thorpe DW, Martin AM, Lu HY, Wang J, Thompson JD, Lickwar CR, Poss KD, Keating DJ, Jordt SE, Clardy J, Liddle RA, Rawls JF. Cell Host Microbe 2020-12-16 A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E. Authors: Authors: Bowden GD, Reis PM, Rogers MB, Bone Relat RM, Brayton KA, Wilson SK, Di Genova BM, Knoll LJ, Nepveux V FJ, Tai AK, Ramadhar TR, Clardy J, O'Connor RM. Int J Parasitol Drugs Drug Resist 2020-07-25 A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity. Authors: Authors: O'Connor RM, Nepveux V FJ, Abenoja J, Bowden G, Reis P, Beaushaw J, Bone Relat RM, Driskell I, Gimenez F, Riggs MW, Schaefer DA, Schmidt EW, Lin Z, Distel DL, Clardy J, Ramadhar TR, Allred DR, Fritz HM, Rathod P, Chery L, White J. PLoS Pathog 2020-05-26 Parsing Molecules for Drug Discovery. Authors: Authors: Walker AS, Pishchany G, Clardy J. Biochemistry 2020-04-21 Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A. Authors: Authors: Reisberg SH, Gao Y, Walker AS, Helfrich EJN, Clardy J, Baran PS. Science 2020-01-02 Cycloheximide-Producing Streptomyces Associated With Xyleborinus saxesenii and Xyleborus affinis Fungus-Farming Ambrosia Beetles. Authors: Authors: Grubbs KJ, Surup F, Biedermann PHW, McDonald BR, Klassen JL, Carlson CM, Clardy J, Currie CR. Front Microbiol 2020-01-01 Molecular messages in human microbiota. Authors: Authors: Henke MT, Clardy J. Science 2019-12-13 Pyonitrins A-D: Chimeric Natural Products Produced by Pseudomonas protegens. Authors: Authors: Mevers E, Saurí J, Helfrich EJN, Henke M, Barns KJ, Bugni TS, Andes D, Currie CR, Clardy J. J Am Chem Soc 2019-10-16 Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide. Authors: Authors: Henke MT, Kenny DJ, Cassilly CD, Vlamakis H, Xavier RJ, Clardy J. Proc Natl Acad Sci U S A 2019-06-25 An elusive electron shuttle from a facultative anaerobe. Authors: Authors: Mevers E, Su L, Pishchany G, Baruch M, Cornejo J, Hobert E, Dimise E, Ajo-Franklin CM, Clardy J. Elife 2019-06-24 GABA-modulating bacteria of the human gut microbiota. Authors: Authors: Strandwitz P, Kim KH, Terekhova D, Liu JK, Sharma A, Levering J, McDonald D, Dietrich D, Ramadhar TR, Lekbua A, Mroue N, Liston C, Stewart EJ, Dubin MJ, Zengler K, Knight R, Gilbert JA, Clardy J, Lewis K. Nat Microbiol 2019-03-01