Ru Yi, ZHU - National University of Singapore

个人简介

NUS Presidential Young Professorship, NUS, 2021 Outstanding Self-Financed Students Abroad Award, China, 2018 Pfizer/CCHF (Center for Selective C−H Functionalization) Symposium Travel Award, Pfizer/CCHF, 2017 ACS GCI Pharmaceutical Roundtable Student Travel Award, ACS Green Chemistry Institute, 2017 Boehringer Ingelheim Fellowship, Boehringer Ingelheim, 2016-2018 AbbVie Scholar Award, AbbVie, 2015 The Best Undergraduate Thesis Award, Peking University, 2013 Excellence in Undergraduate Research Award, Peking University, 2013 May Fourth Scholarship, Peking University, 2012 Panasonic Education Scholarship, Peking University, 2011

研究领域

Next-Generation RNA Therapeutics: We develop efficient synthetic methods to make novel RNA mimetics with improved stability, translation efficiency, and reduced immunogenicity for therapeutic applications including miRNA, siRNA, protein-replacement therapy, mRNA vaccine, and CRISPR. Reprogram RNA with Small-Molecule: We develop general cell-based platforms to identify selective RNA-binding small molecules and use optimized molecules to inhibit/activate RNA function (e.g., translation), degrade RNA, induce alternative splicing, and even edit RNA in vivo. Enzyme-Like DNA Catalyst Design: We design enzyme-like DNA catalyst by merging small-molecule catalysts (i.e., co-factor) with programmable DNA structures (i.e., chiral environment) for unsolved reactivity and selectivity problems in a more sustainable way.

近期论文

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Zhu, R.-Y.; Majumdar, C.; Khuu, C.; De Rosa, M.; Opresko, P. L.; David, S. S.; Kool, E. T. Designer Fluorescent Adenines Enable Real-Time Monitoring of MUTYH Activity. ACS Cent. Sci. 2020, 6, 1735. Zhu, R.-Y.; Li, Z.-Q; Park, H. S.; Senanayake, C. H.; Yu, J.-Q. Ligand-Enabled γ-C(sp3)–H Activation of Ketones. J. Am. Chem. Soc. 2018, 140, 3564. Zhu, R.-Y.; Liu, L-Y.; Park, H. S.; Hong, K.; Wu, Y.; Senanayake, C. H.; Yu, J.-Q. Versatile Alkylation of (Hetero)Aryl Iodides with Ketones via β-C(sp3)–H Activation. J. Am. Chem. Soc. 2017, 139, 16080. Zhu, R.-Y.; Liu, L-Y.; Yu, J.-Q. Highly Versatile β-C(sp3)–H Iodination of Ketones Using a Practical Auxiliary. J. Am. Chem. Soc. 2017, 139, 12394. Zhu, R.-Y.; Saint-Denis, T. G.; Shao, Y.; He, J.; Sieber, J. D.; Senanayake, C. H.; Yu, J.-Q. Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)–H Bonds. J. Am. Chem. Soc. 2017, 139, 5724. Zhu, R.-Y.; Farmer, M. E.; Chen, Y.-Q.; Yu, J.-Q. A Simple and Versatile Amide Directing Group for C−H Functionalizations. Angew. Chem. Int. Ed. 2016, 55, 10578. Zhu, R.-Y.; Tanaka, K.; Li, G.-C.; He, J.; Fu, H.-Y.; Li, S.-H.; Yu, J.-Q. Ligand-Enabled Stereoselective β-C(sp3)–H Fluorination: Synthesis of Unnatural Enantiopure anti-β-Fluoro-α-amino Acids. J. Am. Chem. Soc. 2015, 137, 7067. Zhu, R.-Y.; He, J.; Wang, X.-C.; Yu, J.-Q. Ligand-Promoted Alkylation of C(sp3)–H and C(sp2)–H Bonds. J. Am. Chem. Soc. 2014, 136, 13194. Zhu, R.-Y.; Wei, J.-B.; Shi, Z.-J. Benzofuran Synthesis via Copper-Mediated Oxidative Annulation of Phenols and Unactivated Internal Alkynes. Chem. Sci. 2013, 4, 3706.