王勇 - 中国海洋大学 - 海洋药物教育部重点实验室

个人简介

教育背景 2006.09~2011.07 中科院上海药物研究所药物化学博士 2002.09~2006.07 山东大学制药工程学士工作经历 2020.05~至今中国海洋大学医药学院教授 2015.09~2020.05 法国索邦大学分子化学研究所（IPCM）Feroscan高级研究员（长聘） 2013.03~2015.06 法国巴黎高等化学学校（PSL，ENSCP）博士后 2011.08~2012.11 中科院上海药物研究所助理研究员

研究领域

1. 靶向机体氧化还原系统的药物化学和化学生物学研究 2. 针对肿瘤耐药相关信号通路和靶点的抗癌药物的设计与开发 3. 基于海洋天然产物的靶标发现、结构优化及功能组学研究

近期论文

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J. Yan, K. Yue, X. Fan, X. Xu, J. Wang, M. Qin, Q. Zhang, X. Hou, X. Li*, Y. Wang*. Synthesis and bioactivity evaluation of ferrocene-based hydroxamic acids as selective histone deacetylase 6 inhibitors.Eur. J. Med. Chem.2023, 246, 115004. Y. Wang*, P. Pigeon, W. Li, J. Yan, P. Dansette, M. Othman, M. McGlinchey, G.Jaouen*. Diversity-oriented synthesis and bioactivity evaluation of N-substituted ferrocifen compounds as novel antiproliferative agents against TNBC cancer cells.Eur. J. Med. Chem.2022, 234, 114202. A.Vessières,Y. Wang, M. McGlinchey*, G.Jaouen*. Multifaceted chemical behaviour of metallocene (M= Fe, Os) quinone methides. Their contribution to biology.Coord. Chem. Rev.2021, 430, 213658. Y. Wang, P. Pigeon, S. Top, J. Sanz-García, C. Troufflard, I. Ciofini, M. McGlinchey*, G. Jaouen*. Lone pair-π interaction with quinone methides in a series of imido-ferrociphenol anticancer drug candidates. Angew. Chem. Int. Ed.2019, 58, 8421-8425. Y. Wang, F. Heinemann, S. Top, A. Dazzi, C. Policar, L. Henry, F. Lambert, G. Jaouen, M. Salmain*, A. Vessières*. Ferrocifens labelled with an infrared rhenium tricarbonyl tag: synthesis, antiproliferative activity, quantification and nano IR mapping in cancer cells. Dalton Trans.2018, 47, 9824-9833. Y. Wang, P. Dansette, P. Pigeon, S. Top, M. McGlinchey, D. Mansuy*, G. Jaouen*. A new generation of ferrociphenols leads to a great diversity of reactive metabolites, and exhibits remarkable antiproliferative properties. Chem. Sci.2018, 9, 70-78. (内封面文章) P. Pigeon,#Y. Wang,# S. Top, F. Najlaoui, M. Alvarez, J. Bignon, M. McGlinchey, G. Jaouen*. A new series of succinimido-ferrociphenols and related heterocyclic species induce strong antiproliferative effects, especially against ovarian cancer cells resistant to cisplatin. J. Med. Chem.2017, 20, 8358-8368. (共同第一作者, 封面文章) Y. Wang, P. Pigeon, M. McGlinchey, S. Top*, G. Jaouen*. Synthesis and antiproliferative evaluation of novel hydroxypropyl-ferrociphenol derivatives, resulting from the modification of hydroxyl groups. J. Organomet. Chem.2017, 829, 108-115. Y. Wang, M. Richard, S. Top, P. Dansette, P. Pigeon, A. Vessières, D. Mansuy*, G. Jaouen*. Ferrocenyl Quinone Methide–Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation. Angew. Chem. Int. Ed.2016, 55, 10431-10434. (内封面文章) Y. Wang, P. Pigeon, S. Top, M. McGlinchey, G. Jaouen*. Organometallic Antitumor Compounds: Ferrocifens as Precursors to Quinone Methides. Angew. Chem. Int. Ed.2015, 54, 10230-10233.