朱书雷 - 华东师范大学 - 医学与健康研究院

个人简介

目前从事抗肿瘤药物以及衰老疾病药物的设计与递送工作，致力于开发抗肿瘤药物和衰老相关疾病药物应用的新方法和新技术，解决药物脱靶与在靶毒性问题。通过构建新型酶前药疗法，成功开发出若干新型高效的临床候选药物，已与多个医药公司达成合作，实现科研成果转化。目前，参与设计开发的抗体偶联药物平台，已经获得2个临床批件。以第一/通讯作者在Asian J. Pharm. Sci., J. Med. Chem., Eur. J. Med. Chem.等期刊发表SCI论文16篇；申请发明专利10项；主持和参与国家自然科学基金青年基金项目1项和企业横向合作项目若干项。教育背景 2015-09至2020-07，华东师范大学，有机化学，博士（导师：吕伟研究员）工作经历 2023-10至今，华东师范大学，人工智能新药创智中心，副研究员 2020-07至2023-09，华东师范大学，博士后（合作导师：吕伟研究员）

研究领域

新型抗体药物偶联物衰老疾病相关新药发现新型药物递送系统

近期论文

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Zhu, S. L.; Li, Y. L.; Huang, Y. S.; Zhang, M. M.; Gu, X. F.; He, Y.; Liu, H. C.; Ma, M. L.*; Lu, W*. Optimized HSP90 mediated fluorescent probes for cancer-specific bioimaging. Journal of Materials Chemistry B, 2020, 8, 1878-1896. Zhu, S. L.; Shen, Q. Q.; Gao, Y. L.; Wang, L.; Fang, Y. F.*; Chen, Y.; Lu, W*. Design, synthesis and biological evaluation of HSP90 inhibitor-SN38 conjugates for targeted drug accumulation. Journal of Medicinal Chemistry, 2020, 63, 5421-5441. Zhu, S. L.; Yu, X. M.; He, Y.; Ma, M. L.*; Lu, W*. Synthesis and fluorescent studies of a low molecular weight rotor for living cancer cell imaging. Dyes and Pigments, 2020, 178, 108353. Zhen, Z.#; Zhu, S. L.#; Jin, J. Y.; Wang, L.*; Lu, W*. A water-soluble probe with p-hydrobenzyl quaternary ammonium linker for selective imaging in senescent cells. Analytica Chimica Acta, 2020, 1133, 99-108. Zhu, S. L.; Lu, Y. X.; Jin, J. Y.*; Yu, J. H.; Lu, W*. An HSP90 inhibitor based fluorescent probe for selective tumor targeting. Dyes and Pigments, 2021, 196, 109783. Zhu, S. L.; Liu, J. Y.; Xiao, D. H.; Wang, P. P.; Ma, J. K.; Hu, X. B.; Fu, J. F.; Zhou, Y. B.*; Li, J.*; Lu, W*. Design, synthesis, and biological evaluation of Wee1 kinase degraders. European Journal of Medicinal Chemistry, 2022, 243, 114786. Ding, M. Y.; Shao, Y. Y.; Sun, D. W.; Meng, S. R.; Zang, Y.; Zhou, Y. B.; Li, J.; Lu, W.; Zhu, S. L.* Design, synthesis, and biological evaluation of BRD4 degraders. Bioorganic & Medicinal Chemistry, 2022, 78, 117134. Sun, L.; Zhang, J. F.; Zhou, J. E.; Wang, J.; Wang, Z. H.; Luo, Y. Y.; Zhu, S. L.*; Yang, F.; Tang, J.; Lu, W.; Wang, Y. T.; Yu, L.; Yan, Z. Q*. Monitoring the in vivo siRNA release from lipid nanoparticles based on the fluorescence resonance energy transfer principle. Asian Journal of Pharmaceutical Sciences, 2023, 18, 100769. Cao, Y. T.; Shen, Q. Q.; Ding, M. Y.; Lu, W.; Zhu, S. L.* Development of HSP90 inhibitors-SN38 conjugates for cancer treatment. Bioorganic Chemistry, 2023, 137, 106582. Ding, M. Y.; Shen, Q. Q.; Lu, W*; Zhu, S. L.*. Design, synthesis and biological evaluation of 4-(1H-1,2,3-triazol-1-yl)benzamides as HSP90 inhibitors. Molecular Diversity, 2023, 27, 239-248.