李坤 - 华东师范大学 - 医学与健康研究院

个人简介

李坤，华东师范大学医学与健康研究院副教授，硕士生导师。2020年在华东师范大学获博士学位；2021-2023年在复旦大学附属肿瘤医院做博士后工作； 2023年10月加入华东师范大学。长期聚焦于肿瘤的靶标鉴定与干预策略研究。发表论文10余篇，以第一和通讯作者（含共同）在国际顶级杂志Journal of Clinical Investigation （2 篇）、Cell Death & Disease和 ACS Appl. Mater发表学术论文。先后主持国家自然科学基金青年科学基金项目、上海市启明星培育（扬帆专项）和中国博士后基金特别资助项目等。教育经历 2017.09-2020.12，华东师范大学，博士工作经历 2023.10-至今，华东师范大学医学与健康研究院，副教授 2021.01-2023.10，复旦大学附属肿瘤医院，博士后

研究领域

肿瘤氨基酸代谢相关的新靶标鉴定与干预策略研究动脉粥样硬化及血管再狭窄等心血管疾病氨基酸代谢相关的新靶标鉴定与干预策略研究

近期论文

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Kun Li#; Yanan Liu#; Yi Ding; Zhengwei Zhang; Juanjuan Feng; Jiaxin Hu; Jiwei Chen; Zhengke Lian; Yiliang Chen; Kewen Hu; Zhi Chen; Zhenyu Cai; Mingyao Liu; Xiufeng Pang*; BCL6 is regulatedby the MAPK/ELK1 axis and promotes KRAS-driven lung cancer, Journal of Clinical Investigation, 2022, 132(22) Kewen Hu#; Kun Li#; Jing Lv#; Jie Feng; Jing Chen; Haigang Wu; Feixiong Cheng; Wenhao Jiang;Jieqiong Wang; Haixiang Pei; Paul J. Chiao; Zhenyu Cai; Yihua Chen; Mingyao Liu*; Xiufeng Pang* ; Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma, Journal of Clinical Investigation, 2020, 130(4): 1752-1766 Yuchen Qi#, Yangyang Li#, Kun Li#, Tingting Xie, Shiyuan Hua, Qunfeng Guo*, Yichun Zheng*, and Min Zhou* Biocompatible Gallium Nanodots against Drug-Resistant Bacterial Pneumonia and Liver Abscess. ACS Appl Mater Interfaces, 2023. 15(33): 39143-39156. Yujie Liu#; Ao Leng#; Lin Li#; Bo Yang; Shihui Shen; Hui Chen; Enhao Zhu; Qiyue Xu; Xiaoyu Ma; Peilin Shi; Yun Liu; Tielong Liu; Lei Li; Kun Li*; Dan Zhang*; Jianru Xiao*; AMTB, a TRPM8 antagonist, suppresses growth and metastasis of osteosarcoma through repressing the TGFβ signaling pathway, Cell Death & Disease, 2022, 13(3): 288 Jiawei Guo#; Yanan Liu#; Jing Lv; Bin Zou; Zhi Chen; Kun Li; Juanjuan Feng; Zhenyu Cai; Lai Wei; Mingyao Liu; Xiufeng Pang*; BCL6 confers KRAS-mutant non–small-cell lung cancer resistance to BET inhibitors, Journal of Clinical Investigation, 2021, 131(1): 133090 JuanJuan Feng#; Wenhao Jiang#; Yanan Liu; Wanfeng Huang; Kewen Hu; Kun Li; Jing Chen; Cheng bin Ma*; Zhenliang Sun*; Xiufeng Pang*; Blocking STAT3 by pyrvinium pamoate causes metabolic lethality in KRAS mutant lung cancer, Biochemical Pharmacology, 2020, 177: 113960