个人简介
教育部长江学者特聘教授、国家杰出青年基金获得者、科技部973重大基础研究计划首席科学家、人社部百千万人才工程“有突出贡献中青年专家”、国务院政府特殊津贴获得者、国家自然科学基金委生命科学部咨询组专家、教育部国家教学成果二等奖和全国教材建设一等奖获得者、药明康德生命化学研究奖获得者。
现担任大连医科大学副校长、华东师范大学医学与健康研究院名誉院长。曾任北京大学医学部生理与病理生理学系主任、副院長，深圳大学医学部主任、医学院院長，全国普通高校国家规划教材《医学生理学》主编、国家核心期刊《生理学报》主编， 国际SCI杂志《Journal of Diabetes》副主编、《Frontiers in Physiology》肾脏生理及病生理栏目主编。
管又飞教授长期从事代谢性疾病（如糖尿病、脂肪肝）及其并发症发病机制及治疗策略的研究；脂肪酸代谢产物前列腺素的生物合成调节及其作为疾病治疗靶点的研究。研究受到美国国立卫生研究院(NIH-NIDDK RO1)、国家自然科学基金委杰出青年科学基金、重大项目、重点基金、科技部973项目等的资助。在Nature Medicine、J Clin Invest、Diabetes、Hepatology、PNAS、Am J Physiol 等国际知名杂志上发表180 余篇原著文章。
EDUCATION
M.D. in Medicine, July, 1986
Department of Internal Medicine, Nantong Medical College, Nantong, Jiangsu Province 226001, CHINA
M.S. in Nephrology, Oct., 1989
Department of Internal Medicine, Nantong Medical College, Nantong, Jiangsu Province 226001, CHINA
Ph.D in Nephrology, Nov., 1993
Institute of Nephrology, Beijing Medical University, Beijing 100034, CHINA
Postdoctoral Research Fellow, 1994-1999
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN37232
APPOINTMENTS
2015,05-present Vice President, Dalian Medical University
2015,05-2019,05 Dean, Advanced Institute for Medical Sciences (AIMS)
2013,04- 2015,05 Director, Shenzhen University Health Sciences Medical Center
Dean, Shenzhen University Medical College
Distinguished Professor, Director of AstraZeneca-Shenzhen
University Joint Institute of Nephrology
2008, 07- 2013,05 Associate Dean for Education
School of Basic Medical Sciences, Peking University Health
Science Cente, Beijing 100083
2006, 08- 2015.05 Chair, Department of Physiology and Pathophysiology
Department of Physiology and Pathophysiology, Peking (Beijing) University Health Science Center, Beijing 100083
2005,04-present Changjian Professor of Pathophysiology
The Ministry of Education, People’s Republic of China
2003,09-present Director, Peking University Diabetes Center
2002,09-present Professor of Physiology
Department of Physiology and Pathophysiology, Peking (Beijing) University Health Science Center, Beijing 100083
1999,09-2002,09 Assistant Professor of Medicine
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN37232
1989,08-1991,07 Lecturer and Resident Physician
Division of Nephrology, Department of Internal Medicine, The Affiliated Hospital of Nantong Medical College, Nantong, Jiangsu Province 226001, CHINA
1986,09-1989,08 Graduate Research , Teaching Assistant and Resident Physician
Department of Internal Medicine, Nantong Medical College, Nantong, Jiangsu Province 226001, CHINA
MEMBERSHIP OF ACADEMIC ASSOCIATION
Member of American Society of Nephrology (ASN)
Member of International Society of Nephrology (ISN)
Member of American Physiological Society (APS)
Member of Chinese Society of Physiology (CSP)
Member of American Diabetes Association (ADA)
Member of American Association for the Advancement of Science (AAAS)
AWARD AND HONOR POSITION
Climbing Scholars in Liaoning Province ,2017
Wuxi App Tec prize for the study of life chemistry,2017
The Special allowance of the State Council,2015
High-level Professional（National-level Talent）in Dalian ,2015
High-level Professional（National-level Talent）in Shenzhen ,2014-2019
Chief Scientist, the “973” Program on “Mechanisms involved in dyslipidemia and fatty liver”, The Ministry of Science and Technology, 2012-2017“
Outstanding coutributions of young experts”,The Ministry of Personnel Talents Project,2013
Baosteel Education Foundation Fellowship, 2011;
Distinguished Young Scholar Award, National Natural Science Foundation, 2007
Changjiang Professor at Peking University selected by the Ministry of Education ,2005
Guest Professor, 2002, 1- present, Division of Nephrology, The General Hospital of PLA, Beijing 100021;
Guest Associate Professor, 1998,05-2001,05, Department of Physiology, Beijing University Medical Center (Beijing Medical University), Beijing100081;
National Guang Hua Price, 1993, Beijing Medical University
研究领域
管又飞教授长期从事代谢性疾病（如糖尿病、脂肪肝）及其并发症发病机制及治疗策略的研究；脂肪酸代谢产物前列腺素的生物合成调节及其作为疾病治疗靶点的研究
近期论文
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（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis eLife 2023-02-01 | Journal article | Author
Prostaglandin E 2–Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation The Journal of Immunology 2022-04-15 | Journal article
HSD17B13: A Potential Therapeutic Target for NAFLD Frontiers in Molecular Biosciences 2022-01-07 | Journal article
MHC class II in renal tubules plays an essential role in renal fibrosis Cellular & Molecular Immunology 2021-11 | Journal article
Farnesoid X receptor (FXR) inhibits coagulation process via inducing hepatic antithrombin III expression in mice. Sheng li xue bao : [Acta physiologica Sinica] 2021-10-01 | Journal article
Comment on “Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI” Science Translational Medicine 2021-05-12 | Journal article
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype. Science advances 2021-04-02 | Journal article
Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice. Biochimica et biophysica acta. Molecular basis of disease 2020-10-27 | Journal article
MicroRNAs in type 2 diabetes mellitus: Important for the pathogenesis but uncertain as biomarkers Journal of Diabetes 2020-09 | Journal article
Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells. Pflugers Archiv : European journal of physiology 2020-09-10 | Journal article
Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis. JCI insight 2020-07-09 | Journal article
PPARγ as an E3 Ubiquitin-Ligase Impedes Phosphate-Stat6 Stability and Promotes Prostaglandins E2-Mediated Inhibition of IgE Production in Asthma. Frontiers in immunology 2020-06-19 | Journal article
Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver. Experimental cell research 2020-03-05 | Journal article
SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis Nature Metabolism 2019-11 | Journal article
Aquaporins in the kidney: physiology and pathophysiology. American journal of physiology. Renal physiology 2019-11-04 | Journal article
Role of HSD17B13 in the liver physiology and pathophysiology Molecular and Cellular Endocrinology 2019-06 | Journal article
VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure Proceedings of the National Academy of Sciences 2019-04-23 | Journal article
Excessive Oxidative Stress Contributes to Increased Acute ER Stress Kidney Injury in Aged Mice Oxidative Medicine and Cellular Longevity 2019-01-28 | Journal article
Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability Cellular Physiology and Biochemistry 2018 | Journal article
JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism Cell Death & Disease 2018-09 | Journal article
Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2 Circulation 2018-07-03 | Journal article
Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress Proceedings of the National Academy of Sciences 2018-05-22 | Journal article
FAM3 gene family: A promising therapeutical target for NAFLD and type 2 diabetes Metabolism 2018-04 | Journal article
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2018-03 | Journal article
Prostaglandin E2 Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling Frontiers in Immunology 2018-03-12 | Journal article
Erratum. Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure. Diabetes 2017;66:640–650 Diabetes 2017-12 | Journal article
Prostaglandin E2 in the Regulation of Water Transport in Renal Collecting Ducts International Journal of Molecular Sciences 2017-11-27 | Journal article
Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNFα in Vascular Endothelial Cells through a PXR-Dependent Mechanism Molecular Pharmacology 2017-09 | Journal article
NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway Diabetes 2017-07-01 | Journal article
Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice Diabetes 2017-05-01 | Journal article
Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c American Journal of Physiology-Endocrinology and Metabolism 2017-04-01 | Journal article
Liver X receptor β increases aquaporin 2 protein level via a posttranscriptional mechanism in renal collecting ducts American Journal of Physiology-Renal Physiology 2017-04-01 | Journal article
Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis Proceedings of the National Academy of Sciences 2017-03-21 | Journal article
Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure Diabetes 2017-03-01 | Journal article
Knockout of the Prostaglandin E2 Receptor Subtype 3 Promotes Eccentric Cardiac Hypertrophy and Fibrosis in Mice Journal of Cardiovascular Pharmacology and Therapeutics 2017-01 | Journal article
An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice Scientific Reports 2016-12 | Journal article
Intermedin1-53 Attenuates Abdominal Aortic Aneurysm by Inhibiting Oxidative Stress Arteriosclerosis, Thrombosis, and Vascular Biology 2016-11 | Journal article
Prostaglandin E2 receptor EP3 regulates both adipogenesis and lipolysis in mouse white adipose tissue. Journal of molecular cell biology 2016-07-19 | Journal article
Nuclear Receptor Regulation of Aquaporin-2 in the Kidney International Journal of Molecular Sciences 2016-07-11 | Journal article
Prostaglandins E2 signal mediated by receptor subtype EP2 promotes IgE production in vivo and contributes to asthma development Scientific Reports 2016-04-22 | Journal article
Intermedin1–53 attenuates vascular calcification in rats with chronic kidney disease by upregulation of α-Klotho Kidney International 2016-03 | Journal article
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