王雪力 - 华东师范大学 - 精密光谱科学与技术国家重点实验室

个人简介

王雪力，博士毕业于华东师范大学精密光谱科学与技术国家重点实验室。期间前往美国俄亥俄州立大学化学与生物化学系访学。主要研究方向是采用各类超快光谱技术研究生物大分子中激发态动力学过程，包括DNA大分子的光损伤与光稳定机制、药物敏化DNA光损伤与保护机制、分子的手性动力学机制等。近年来工作已在JACS，Angew. Chem. Int. Ed., Nat. Commun.，Chem. Sci., JPCL, JPCA/B/C, JCP, PCCP 等期刊发表,目前共发表论文40余篇。2023年7月以专任副研究员加入陈缙泉教授团队。教育经历 2016.9 - 2021.6 华东师范大学精密光谱科学与技术国家重点实验室（博士） 2020.1 - 2020.7 美国俄亥俄州立大学化学与生物化学系（访问学者）工作经历 2023.7 - 至今华东师范大学精密光谱科学与技术国家重点实验室（专职副研究员） 2021.6 - 2023.6 华东师范大学精密光谱科学与技术国家重点实验室（博士后）

研究领域

激发态超快动力学，生物光子学，DNA损伤与修复，飞秒时间分辨的圆二色吸收光谱

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang, X. ; Wu, P.; Wang, Y.; Cui, T.; Jia, M.; He, X.; Wang, W.; Pan, H.; Sun, Z.; Yang, H.; Chen, J.*; Unraveling the Origin of Multichannel Circularly Polarized Luminescence in a Pyrene-Functionalized Topologically Chiral [2]Catenane. Angew. Chem. Int. Ed. 2024, e202407929. Cui, T; Jia, M*; Wu, P; Hu, K; Wang, X. ; Zhang, S; Pan, H; Chen, J*; Development and Application of Ultrafast Circular Dichroism Spectroscopy Techniques CHINESE J. CHEM. PHYS. DOI: 10.1063/1674-0068/cjcp2403041 Hu, K; He, X* ; Jin, P;Wang, X.; Pan, H.; Chen, J.*, Unravelling the Competition between Internal Conversion and Intersystem Crossing in Twisted molecule 9-Phenylacridine by Femtosecond Time-resolved Spectroscopy. ChemPhotoChem 2024,e202400108 Chen, Z.; Wang, X.*; Jia, M.; He, X.; Pan, H.; Chen, J.*, Ribose and Deoxyribose Group Alter Excited-State Dynamics of 5-Azacytosine in Solution. Photochem. Photobiol. 2024,100, 291-297 Zhou, J.; Wang, X.*; Jia , M.; He, X.; Pan, H.; Chen, J.* Ultrafast Spectroscopy Study of DNA Photophysics after Proflavine Intercalation. J. Chem. Phys. 2024, 160, 124305 Jin, P.; Wang, X.* ; Jia , M .; He, X.; Pan, H.; Chen, J. *, Ultrafast and Multichannel Generation of Triplet State in DNA Intercalated Gilvocarcin V for Enhanced Photo Addition Reaction . J. Phys. Chem. Lett. 2024, 15, 2765-2771 Wang, X. ; Martinez Fernandez, L. ; Zhang, Y.; Wu, P.; Kohler, B.*；Improta, R. *； Chen, J. *, Ultrafast Formation of a Delocalized Triplet Excited State in an Epigenetically Modified DNA Duplex under Direct UV Excitation J. Am. Chem. Soc. 2024, 146, 1839 1848. Chen, J.; Liu, Y.; Chen, F.; Guo, M.; Zhou, J.; Fu, P.; Zhang, X.; Wang, X.; Wang, H.; Hua, W.; Chen, J.; Hu, J.; Mao, Y.*; Jin, D.*; Bu, W.*; Non-Faradaic optoelectrodes for safe electrical neuromodulation. Nat. Commun. 2024, 15, 405 Wu, P.; Wang, X.*; Pan, H.; Chen, J.*; Wavelength dependent excited state dynamics observed in canonical pyrimidine nucleosides . J . Photochem. Photobio.2023, 1(8), 100211. Luo, X.*; Zhang, Z.*; Wang, J.; Wang, X.; Zhang, Y.; Chen, J. Ge, G.; Yang,W.*; Qian, X.*; Tian, Y.*; Yang, Y.*; Acyl-Caged Rhodamines: Photo-Controlled and Self-Calibrated Generation of Acetyl Radical for Neural Function Recovery in Early AD Mouse. Chem. Sci. 2023,14,11689-11698 Jin, P.; Wang, J.; Wang, X.; Jia, M.; Pan, H.; Mei, Y.*; Chen, J.*, Tracking the Early Stage of Triplet-Induced Photodamage in a DNA Dimer and Oligomer Containing 5-Methylcytosine J. Phys. Chem. B 2023, 127 (31), 6878-6886. Han, Y.; Wang, X.* ; He, X.; Jia , M.; Pan, H.; Chen, J.* Excited State Kinetics ofBenzo[a]pyrene Is Affected by Oxygen and DNA . Molecules 2023, 28, 5269 Wang, M.; Wang, X.; Wei, R.; Zhang, Y.; Chen, J.; Luo, X,; Qian, X.; Yang, Y.; Symmetry-breaking charge-transfer enables turn-on fluorescence sensing in the shortwave infrared spectral region for in vivo vasculature redox homeostasis Sensor Actuat B-chem 2023，394,134382 Wang, D.; Wang, X.* ; Jin , P ; Zhou , Y ; Jia , M .; Pan, H.; Sun, Z. Chen, J.*, Distinct doorway states lead to triplet excited state generation in epigenetic RNA nucleosides Phys. Chem. Chem. Phys. 2023, 25,15153--15161. Wei, R.; Dong, Y.; Wang, X.; Li J.; Lei Z., Hu, Z.; Chen, J., Sun, H., Chen, H., Luo, H., Qian, H.; Yang, Y. Rigid and Photostable Shortwave Infrared Fluorophore (EC7)Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging J. Am. Chem. Soc. 2023, 145 (22), 12013-12022. Jin, X.; Guo, S.; Wang, X.; Cong, Y.; Chen, J.*; Zhang, Z.*; Su, J.; Qu, D.; Tian, H.*, Sequential Multistep Excited-State Structural Transformations in N,N′-Diphenyl-dihydrodibenzo[a,c]phenazine Fluorophores. Angew. Chem. Int. Ed. 2023, 6(29), e202305572. Han, Y.; Jia, Y.*; Wang, X.; Chen, Z.; Jin, P.; Jia, M.; Pan, H.; Sun, Z.; Chen, J.*, Ultrafast excited state dynamics of two non-emissive flavonoids that undergo excited state intramolecular proton transfer in solution. Chem. Phys. Lett. 2023, 811, 140189. Zhou, J.; Jia, Y.*; Wang, X.; Jia, M.; Pan, H.; Sun, Z.; Chen, J.*, Excited-State Dynamics of Proflavine after Intercalation into DNA Duplex. Molecules 2022, 27 (23), 8157. Li, X.; Wang, X.*; Lv, M.; Zhou, Z.; Pan, H.; Chen, J.*, Direct observation of singlet ππ? and nπ* equilibrium state in 2-amino-1,3,5-triazine solution. Chinese J. Chem. Phys. 2022, 35, 747-753. Wu, P.; Wang, X.; Pan, H.; Chen, J.*, Direct Observation of Excitation Wavelength-Dependent Ultrafast Intersystem Crossing in Cytosine Nucleoside Solution. J. Phys. Chem. B 2022, 126 (40), 7975-7980. Chen, L.; Jiang, X.; Lv, M.; Wang, X.; Zhao, P.; Zhang, M.; Lv, G.; Wu, J.; Liu, Y.; Yang, Y.*; Chen, J.*; Bu, W.*, Reductive-damage-induced intracellular maladaptation for cancer electronic interference therapy. Chem 2022, 8 (3), 866-879. Wang, D.; Wang, X.*; Jiang, Y.; Cao, S.; Jin, P.; Pan, H.; Sun, H.; Sun, Z.; Chen, J.*, Excited State Dynamics of Methylated Guanosine Derivatives Revealed by Femtosecond Time-resolved Spectroscopy. Photochem. Photobiol. 2022, 98,1008-1016. Jin, P.;Wang, X.*; Pan, H.; Chen, J.*, One order of magnitude increase of triplet state lifetime observed in deprotonated form selenium substituted uracil. Phys. Chem. Chem. Phys. 2022, 24, 875-882. Tan, H.; Zhou, H.; Zhao, Y.; Wang, X.; He, X.; Chen, J.; Zhang, K.*; Antoine, R.*; Zhang, S.*; Tian, Y., Regulation of Silver Nanoclusters with 4 Orders of Magnitude Variation of Fluorescence Lifetimes with Solvent-Induced Noncovalent Interaction. J. Phys. Chem. C 2022, 126 , 5198-5205. Lv, M.; Wang, X.; Pan, H.; Chen, J.*, Direct Observation of Ultrafast Access to a Solvent-Independent Singlet–Triplet Equilibrium State in Acridone Solutions. J. Phys. Chem. B 2021, 125 , 13291-13297. Lv, M.; Wang, X.; Wang, D.; Li, X.; Liu, Y.; Pan, H.; Zhang, S.; Xu, J.; Chen, J.*, Unravelling the role of charge transfer state during ultrafast intersystem crossing in compact organic chromophores. Phys. Chem. Chem. Phys. 2021. 25455-25466. 王雪力，潘海峰，陈缙泉* 表观遗传修饰核酸碱基的超快激发态动力学研究《物理学进展》 2021, 41, 199-208 Wang, X.; Martinez-Fernandez, L.; Zhang, Y.; Zhang K.; Improta, R.*；Kohler, B.*；Xu, J.; Chen, J.*, Solvent-dependent Stabilization of a Charge Transfer State is the Key to Ultrafast Triplet State Formation in an Epigenetic DNA Nucleoside. Chem. Eur. J. 2021, 42 , 10932-10940. Zhang, K.; Wang, F.; Jiang, Y.; Wang, X.; Pan, H.; Sun, Z.; Sun, H.; Xu, J.; Chen, J.*, New Insights about the Photostability of DNA/RNA Bases: Triplet nπ* State Leads to Effective Intersystem Crossing in Pyrimidinones. J. Phys. Chem. B 2021，125, 2042-2049. Xu, R.; Hu, Z.; Wang, X.; Liu, Y.; Zhou, Z.; Xu, J.; Sun, Z.; Sun, H.; Chen, J.*, Intramolecular Charge Transfer in 5-Halogen Cytidines Revealed by Femtosecond Time-Resolved Spectroscopy. J. Phys. Chem. B 2020, 124 , 2560-2567. Liu, Y.; Chen, Z.; Wang, X.; Cao, S.; Xu, J.; Jimenez, R.*; Chen, J.*, Ultrafast spectroscopy of biliverdin dimethyl ester in solution: pathways of excited-state depopulation. Phys. Chem. Chem. Phys. 2020, 22, 19903-19912. Li, W.; Wang, X. Q.; Wang, W.; Hu, Z.; Ke, Y.; Jiang, H.; He, C.; Wang, X.; Hu, Y.; Jia, P.; Yin, P.; Chen, J.; Sun, H.; Sun, Z.; Xu, L.*;Yang, H. *, Dynamic Artificial Light-Harvesting Systems Based on Rotaxane Dendrimers. Giant 2020, 100020. Fu, L.; Wang, Z.; Liu, Y.; Wang, X.; Xu, R.; Liu, W.*; Chen, J.*; Xu, J., Observation of triplet nπ* state in ultrafast intersystem crossing of 6-azathymine. J. Photochem. Photobiol. A: Chem. 2020, 396, 112491. Wang, X.; Yu, Y.; Zhou, Z.; Liu, Y.; Yang, Y.; Xu, J.; Chen, J.*, Ultrafast Intersystem Crossing in Epigenetic DNA Nucleoside 2′-Deoxy-5-formylcytidine. J. Phys. Chem. B 2019, 123 , 5782-5790. Zhou, Z.; Wang, X.; Chen, J.*; Xu, J., Direct Observation of Intramolecular Charge Transfer State in Epigenetic Nucleobase N6-methyladenine. Phys. Chem. Chem. Phys. 2019, 21, 6878-6885. Zhou, Z.; Hu, Z.; Zhang, X.; Jia, M.; Wang, X.; Su, H.; Sun, H.; Chen, J.*; Xu, J., pH Controlled Intersystem Crossing and Singlet Oxygen Generation of 8-Azaadenine in Aqueous Solution. ChemPhysChem 2019, 20 , 757-765. Wang,X.; Zhou, Z.; Tang, Y.; Chen, J.*; Zhong, D.; Xu, J., Excited State Decay Pathways of 2'-deoxy-5-Methylcytidine and Deoxycytidine Revisited in Solution: A Comprehensive Kinetic Study by Femtosecond Transient Absorption. J. Phys. Chem. B 2018, 122, 7027-7037. He, H.; Liu, Y.; Zhou, Z.; Guo, C.; Wang, H. Y.; Wang, Z.; Wang, X.; Zhang, Z.; Wu, F. G.; Wang, H.;Chen, D.; Yang, D.; Liang, X.*; Chen, J.*; Zhou, S.*; Liang, X*; Qian, X.; Yang, Y.*, A Photo-Triggered and Photo-Calibrated Nitric Oxide Donor: Rational Design, Spectral Characterizations, and Biological Applications. Free Radical Biology & Medicine 2018, 123, 1-7. Lei, Z.; Yue, P.; Wang, X.; Li, X.; Li, Y.; He, H.; Luo, X.; Meng, X.*; Chen, J.*; Qian, X.,Yang, Y.*, TPZ, a bright centrosymmetric two-photon scaffold for bioimaging. Chem. Commun. 2017, 10938. Zhou, Z.; Zhou, X.; Wang, X.; Jiang, B.*; Li, Y.*; Chen, J.*; Xu, J., Ultrafast Excited-State Dynamics of Cytosine Aza-Derivative and Analogues. J. Phys. Chem. A 2017, 121 , 2780-2789.