张志民 - 暨南大学

个人简介

张志民，理学博士，研究员，博士生导师。2003年6月本科毕业于中南大学材料科学与工程专业；2012年6月获得中科院上海有机化学研究所博士学位；同年赴加州大学河滨分校（UCR）从事博士后研究。2017年入职暨南大学药学院生物制药系。长期以具有重要生理功能和新颖催化机制的化学修饰酶为研究对象，致力于酶的结构生物与结构药理学研究。近年来以（共）第一/通讯作者在Nature、Nature Communications、Nature Plants、Nature Structural & Molecular Biology、J. Am. Chem. Soc. 、Angew. Chem.Int. Ed.和J. Med. Chem.等国际知名期刊发表研究论文多篇。入选广东省“珠江人才”计划青年拔尖人才。

研究领域

1、潜在药物靶标的作用机制研究 2、酶催化药物分子的生物合成机制 3、药物与靶蛋白作用机制研究

近期论文

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Ji-Qiang Jin#, Fu-Rong Qu#, Huisi Huang#, Qing-Shuai Liu#, Yuee Zhou, Zhibo Cui, Meng-Yuan Wei, Jie-Dan Chen, Wei-Dong Dai, Li Zhu, Ming-Zhe Yao*, Zhi-Min Zhang*, Liang Chen*. Identification and characterization of two O-methyltransferases involved in the biosynthesis of O-methylated catechins in tea plant. Nat. Commun.2023, 14:5075 Zhongtang Yu# , Xiaoqiang He#, Ruiliu Wang#, Xinxin Xu, Zhang Zhang, Ke Ding*, Zhi-Min Zhang*, Yi Tan*, Zhengqiu Li*. Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles. J. Am. Chem. Soc. 2023, doi:10.1021/jacs.3c05899. Peng Chen#, Guanghui Tang#*, Chengjun Zhu#, Jie Sun, Xuan Wang, Menghua Xiang, Huisi Huang, Wei Wang, Lin Li, Zhi-Min Zhang*, Liqian Gao*, and Shao Q. Yao*. 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J. Am. Chem. Soc. 2023, 145(7): 3844-3849. Zuqin Wang#, Jie Wang#, Yongjin Wang#, Shuang Xiang, Hengliang Zhou, Shukai Song, Xiaojuan Song, Zhengchao Tu, Yang Zhou, Ke Ding, Zhi-Min Zhang*, Zhang Zhang* and Xiaoyun Lu*. Structure-based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-front, xDFG and Gatekeeper Mutations. J. Med. Chem. 2023, 10.1021/acs. jmedchem.3c00899 Peng Chen#, Jie Sun#, Chengjun Zhu#, Guanghui Tang*, Wei Wang, Manyi Xu, Menghua Xiang, ChongJing Zhang, Zhi-Min Zhang*, Liqian Gao*, Shao Q Yao*. Cell-Active, Reversible, and Irreversible Covalent Inhibitors that Selectively Target the Catalytic Lysine of BCR-ABL Kinase, Angew. Chem. Int. Ed., 2022, 61(26):e202203878 Yongjin Wang#, Yang Zhou#, Guohua Lv#, Jiacong Liu, Huisi Huang, Shengrong Li, Liping Duan, Xinyi Zheng, Yue Liu, Haibo Zhou, Zhengqiu Li, Yonghua Wang, Yun Huang, Ke Ding*, Pinghua Sun*, Xiaoyun Lu*, Zhi-Min Zhang*. A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria, Nat. Commun.2022, 13: 6434. Yifan Ouyang#, Hongfei Si#, Chengjun Zhu#, Liang Zhong, Haowen Ma, Zongyang Li, Xiong H, Liu Tongzheng, Liu Zhong, Zhang Zhang*, Zhi-Min Zhang*, Qian Cai*. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluorometh -yl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J. Med. Chem. 2022, 65 (11): 7833–7842 Zuqin Wang#, Jie Wang#, Yongjin Wang#, Shuang Xiang, Xiaojuan Song, Zhengchao Tu, Yang Zhou, Zhi-Min Zhang*, Zhang Zhang*, Ke Ding*, Xiaoyun Lu*. Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance, J. Med. Chem., 2022, doi:10.1021/acs.jmedchem.2c00308 Yao Xia#, Rongfeng Zou#, Maxime Escouboué#, Liang Zhong#, Chengjun Zhu, Cécile Pouzet, Xueqiang Wu, Yongjin Wang, Guohua Lv, Haibo Zhou, Pinghua Sun*, Ke Ding*, Laurent Deslandes*, Shuguang Yuan*, Zhi-Min Zhang*. Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase, Nat. Commun., 2021, 12: 5969. Zexing Wen#, Zhi-Min Zhang#, Liang Zhong#, Jiaqian Fan, Min Li, Yuanhong Ma, Yang Zhou, Wei Zhang, Bin Guo, Bo Chen, and Jian-Bo Wang. Directed Evolution of a Plant Glycosyltransferase for Chemo- and Regioselective Glycosylation of Pharmaceutically Significant Flavonoids, ACS Catalysis, 2021, doi: 10.1021/acscatal. 1c04191 Youlong Fan#, Hongfei Si#, Zhang Zhang, Liang Zhong, Hongyan Sun, Chengjun Zhu, Zhibin Yin, Huilin Li, Guanghui Tang, Shao Q Yao, Pinghua Sun*, Zhi-Min Zhang*, Ke Ding*, Zhengqiu Li*. Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery, J. Med. Chem., 2021, doi: 10.1021/acs.jmedchem.0c02024 Yue-Hong Zhang#, Yi-Fang Li#, Yongjin Wang#, Li Tan, Zhi-Qin Cao, Chao Xie, Guo Xie, Hai-Biao Gong, Wan-Yang Sun, Shu-Hua Ouyang, Wen-Jun Duan, Xiao yun Lu, Ke Ding, Hiroshi Kurihara, Dan Hu*, Zhi-Min Zhang*, Ikuro Abe*, and Rong-Rong He*. Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea，Nat. Commun., 2020, 11: 1473. Zhi-Min Zhang#, Rui Lu#, Pengcheng Wang, Yang Yu, Dongliang Chen, Linfeng Gao, Shuo Liu, Debin Ji, Scott B. Rothbart, Yinsheng Wang, Gang Greg Wang*&Jikui Song*. Structural basis for DNMT3A-mediated de novo DNA methylation, Nature, 2018, 554(7692): 387-391 Zhi-Min Zhang#, Ka-Wai Ma#, Linfeng Gao#, Zhenquan Hu, Simon Schwizer, Wenbo Ma*, and Jikui Song*. Mechanism of Host Substrate Acetylation by a Yopj Family Effector. Nat. Plants, 2017, 3:17115. Zhi-Min Zhang#, Ka-Wai Ma#, Shuguang Yuan, Youfu Luo, Shushu Jiang, Eva Hawara, Songqin Pan, Wenbo Ma*, Jikui Song*. Structure of a pathogen effector reveals enzymatic mechanism of a novel acetyltransferase family, Nat. Struct & Mol. Biol., 2016, 23(9):847-852.