胡鹏飞 - 西湖大学

个人简介

Pengfei received Master of Science degree (2014) at East China University of Science and Technology (ECUST) under the supervision of Prof. Xiaofeng Tong. He then joined Prof. Scott A. Snyder’s group and earned PhD degree in August 2019 at University of Chicago. From September 2019 to March 2021, Pengfei conducted postdoc research with Prof. Phil S. Baran at The Scripps Research Institute, where he was a Hewitt Foundation Fellow working on synthetic electrochemistry. He is currently an assistant professor at Westlake University since April 2021. His research interest is total synthesis of bioactive natural product, synthetic electrochemical chemistry, and medicinal chemistry. Selected honors and awards 23rd International Conference on Organic Synthesis Oral Speaker Award (2023) Distinguied Young Scholars of NSFC (Overseas) (2022) Chinese Government Award for Outstanding Self-financed Students Abroad (2020) Elizabeth R. Norton Prize for Excellence in Research in Chemistry (2019) Bristol-Myers Squibb Graduate Fellowship in Synthetic Organic Chemistry (2018) William Rainey Harper Dissertation Fellowship (one of UChicago’s highest honors) (2018) Morris Selig Kharasch Lecture Graduate Fellowship (2018) Chancellor Siwei Cheng’s Award (2014) National Scholarship for Outstanding Graduate Students of China (2013)

研究领域

The Hu lab aims at developing efficient and scalable chemical synthesis of complex, biologically active molecules. This mission includes the pursuit of new guidelines, strategies and tatics for synthesizing natural products with densely functionalized skeleton, as well as new methodology development by harnessing the reactivity and selectivity of highly reactive intermediates.

近期论文

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Chen Peng, Quanping Guo, Guo-Xiong Xu, Luqiong Huo, Weilin Wu, Tian-Yi Chen, Xin Hong, Pengfei Hu. Divergent Synthesis of Scabrolide A and Havellockate via an exo-exo-endo Radical Cascade. J. Am. Chem. Soc. 2024 ASAP. Quanping Guo, Yangye Jiang, Rongjin Zhu, Wenhui Yang, Pengfei Hu. Electrochemical Azo-free Mitsunobu-type Reaction. Angew. Chem. Int. Ed. 2024 e202402878. Pengfei Hu, Byron Peters, Christian A. Malapit, Julien C. Vantourout, Pan Wang, Jinjun Li, Lucas Mele, Pierre-Georges Echeverria, Shelley D. Minteer, Phil S. Baran. Electroreductive Olefin Ketone Coupling. J. Am. Chem. Soc. 2020, 142, 20979. Hyung Min Chi, Charles Cole, Pengfei Hu, Cooper A. Taylor, Scott A. Snyder. Total synthesis of Spiroviolene and Spirograterpene A: a Structural Reassignment with Biosynthetic Implications. Chem. Sci. 2020, 11, 10939. Pengfei Hu, Hyung Min Chi, Kenneth C. DeBacker, Xu Gong, Jonathan H. Keim, Ian Tingyung Hsu, Scott A. Snyder. Quaternary Center-Guided Synthesis: Concise Preparations of Complex Polycyclic Terpenes. Nature 2019, 569, 703. Heng Yi, Pengfei Hu, Scott A. Snyder. Development and Elucidation of a Pd-based Cyclization/Oxygenation Sequence for Natural Product Synthesis. Angew. Chem. Int. Ed. 2020, 59, 2674. Pengfei Hu, Scott A. Snyder. Enantiospecific Total Synthesis of the Highly Strained (−)-Presilphiperfolan-8-ol via a Pd-Catalyzed Tandem Cyclization. J. Am. Chem. Soc. 2017, 139, 5007. Yiting Gu, Pengfei Hu, Chunjie Ni, Xiaofeng Tong. Phosphine-Catalyzed Addition/Cycloaddition Domino Reactions of β′-Acetoxy Allenoate: Highly Stereoselective Access to 2-Oxabicyclo[3.3.1]nonane and Cyclopenta[a]pyrrolizine. J. Am. Chem. Soc. 2015, 137, 6400. Yiting Gu, Falin Li, Pengfei Hu, Daohua Liao, Xiaofeng Tong. Tertiary Amine-Catalyzed (4 + 2) Annulations of δ-Acetoxy Allenoates: Synthesis of Multisubstituted 4H-Pyran and 4H-Chromene. Org. Lett. 2015, 17, 1106. Wei Dong, Pengfei Hu, Jian Hu, Xiaofeng Tong. Lewis Base-Catalyzed Divergent Isomerizations of 5-Hydroxy-2,3-dienoate. Tetrahedron Lett. 2014, 55, 1682. Pengfei Hu, Jian Hu, Jiajun Jiao, Xiaofeng Tong. Amine-Promoted Asymmetric (4 + 2) Annulations for the Enantioselective Synthesis of Tetrahydropyridines: A Traceless and Recoverable Auxiliary Strategy. Angew. Chem. Int. Ed. 2013, 52, 5319.