袁小兵 - 华东师范大学 - 生命科学学院

研究领域

神经元迁移的分子细胞机制、自闭症等神经发育相关疾病的分子机理及实验治疗。主要运用小鼠遗传学、生物信息学、组织学、行为学、生物化学与细胞生物学等研究手段，研究: （1）神经元迁移及其导向的基本原理（2）自闭症风险基因如何影响脑发育（3）自闭症风险基因的汇聚通路及干预靶点（4）在动物模型上建立自闭症等发育相关神经系统疾病的实验治疗方案

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Zhao PP, Yao MJ, Chang SY, Yuan XB#. Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins. Molecular Brain. 8:39 (2015). Jiang J, Zhang ZH, Yuan XB, Poo MM#. Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons. J Cell Biol. 209:759-74 (2015). Zheng W, Geng AQ, Li PF, Wang Y, Yuan XB#. Robo4 regulates the radial migration of newborn neurons in developing neocortex. Cerebral Cortex 22(11):2587-601 (2012). He M, Zhang ZH, Guan CB, Xia D, Yuan XB#. Leading tip drives soma translocation via forward F-actin flow during neuronal migration. J. Neurosci. 30:10885–10898 (2010). Zhao CT, Li K, Li JT, Zheng W, Liang XJ, Geng AQ, Li N, and Yuan XB#. PKCδ regulates cortical radial migration by stabilizing the Cdk5 activator p35. Proc Natl Acad Sci U S A. 106: 21353-21358 (2009). Chen G, Sima J, Jin M, Zheng W, Wang KY, Xue XJ, Ding YQ, Yuan XB#. Semaphorin-3A guides radial migration of cortical neurons during development. Nature Neurosci., 11: 36-44 (2008). Guan CB, Xu HT, Jin M, Yuan XB#, and Poo MM#. Long-range Ca2+ signaling from growth cone to soma mediates reversal of neuronal migration induced by Slit-2. Cell 129: 385-395 (2007).