个人简介
吕佳，女，理学博士，主要从事“功能高分子生物大分子载体材料”领域相关研究。包括新型蛋白质胞内递送载体的设计、构效关系研究以及转化应用等。2009年9月进入西北农林科技大学植物保护学院制药工程专业，攻读学士学位。2013年9月进入华东师范大学生命科学学院生物化学与分子生物学专业，期间获得2014年全国高分子材料科学与工程研讨会“优秀墙报奖”，“研究生国家奖学金”，“华东师范大学优秀学生”，于2018年6月获得理学博士学位。2018年11月进入华南理工大学分子科学与工程学院（华南软物质科学与技术高等研究院）从事博士后研究。2021年11月进入华东师范大学生命科学学院担任青年研究员，至今已在Chemical Society Reviews, Nano Letters, Biomaterials, Journal of Controlled Release, Science China Materials等国际权威学术期刊发表第一/通讯作者 SCI 论文 十余篇（其中 1 区论文 11 篇， IF>10 的论文 8 篇），申请国家发明专利4项（授权2项）。获得国家自然科学基金面上项目、青年基金项目，中国博士后科学基金面上项目的支持。
工作经历
2018-11至2021-11, 华南理工大学，博士后
2021-11至今，华东师范大学，研究员
教育经历
2013-09 至 2018-06, 华东师范大学, 生化与分子生物学, 博士
2009-09 至 2013-07, 西北农林科技大学, 制药工程, 学士
近期论文
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Jia Lv, Hui Wang, Guangyu Rong, Yiyun Cheng*. Fluorination promotes the cytosolic delivery of genes, proteins, and peptides. Accounts Chem. Res., 2022, 55, 722-733.
Jia Lv, Yiyun Cheng*. Fluoropolymers in biomedical applications: state of the art and future perspectives. Chem. Soc. Rev., 2021, 50, 5435-5467.
Jia Lv, Changping Wang, Hongru Li, Zhan Li, Qianqian Fan, Ying Zhang, Yiwen Li, Hui Wang*, Yiyun Cheng*. Bifunctional and bioreducible dendrimer bearing a fluoroalkyl tail for efficient protein delivery both in vitro and in vivo. Nano Lett., 2020, 20, 8600-8607.
Jia Lv, Echuan Tan, Yuqing Wang, Qianqian Fan, Jingwen Yu, Yiyun Cheng*. Tailoring guanidyl-rich polymers for efficient cytosolic protein deliver. J. Control. Release, 2020, 320, 412-420.
Jia Lv, Chongyi Liu, Kexin Lv, Hui Wang, Yiyun Cheng*. Boronic acid-rich dendrimer for efficient intracellular peptide delivery. Sci. China Mater., 2020, 63, 620-628.
Jia Lv, Qianqian Fan, Hui Wang, Yiyun Cheng*. Polymers for cytosolic protein delivery. Biomaterials, 2019, 218, 119358.
Jia Lv#, Bingwei He#, Jingwen Yu, Yitong Wang, Changping Wang, Song Zhang, Hui Wang, Jingjing Hu, Qiang Zhang, Yiyun Cheng*. Fluoropolymers for intracellular and in vivo protein delivery. Biomaterials, 2018, 182, 167-175. (#co-first author)
Jia Lv#, Hong Chang#, Yu Wang, Mingming Wang, Jianru Xiao, Qiang Zhang, Yiyun Cheng*. Fluorination on polyethylenimine allows efficient 2D and 3D cell culture gene delivery. J Mater Chem B. 2015, 3, 642-650. (#co-first author)
Xujiao Zhou#, Jia Lv#, Gang Li, Tingting Qian, Hao Jiang, Jianjiang Xu, Yiyun Cheng, Jiaxu Hong*. Rescue the retina after the ischemic injury by polymer-mediated intracellular superoxide dismutase delivery. Biomaterials, 2021, 268, 120600. (#co-first author)
Hong Chang#, Jia Lv#, Xin Gao, Xing Wang, Hui Wang, Hui Chen, Xu He, Lei Li, Yiyun Cheng*. Rational design of a polymer with robust efficacy for intracellular protein and peptide delivery, Nano Lett., 2017, 17, 1678-1684. (#co-first author, Highlighted by Faculty of 1000)
Hui Wang, Song Zhang, Jia Lv*, Yiyun Cheng*. Design of polymers for siRNA delivery: recent progress and challenges. View, 2021, 2, 20200026. (*co-corresponding author)
Chunlei Yu, Echuan Tan, Yangyang Xu, Jia Lv*, Yiyun Cheng*. A guanidinium-rich polymer for efficient cytosolic delivery of native proteins. Bioconjugate Chem., 2019, 30, 413-417. (*co-corresponding author)
郁静雯，吕佳*，程义云*。氟化修饰显著提高碳点的抗菌活性，化学通报，2020，83，360-368. (*co-corresponding author)
Jun Xu, Jia Lv, Qi Zhuang, Zongjin Yang, Zhiqin Cao, Ligeng Xu, Pei Pei, Chenya Wang, Hanfei Wu, Ziliang Dong, Yu Chao, Chao Wang, Kai Yang, Rui Peng*, Yiyun Cheng*, Zhuang Liu*. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy. Nat. Nanotechnol., 2020, 15, 1043-1052.
Lanfang Ren, Jia Lv, Hui Wang und Yiyun Cheng*. A coordinative dendrimer achieves excellent efficiency in cytosolic protein and peptide delivery.Angew. Chem. Int. Ed. 2020, 59, 4711–4719.
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