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Shaoying Zhang#, Demin Ma# , Kun Wang# , Ya Li#, Zhenni Yang, Xiaoxiao Li, Junnan Li, Jiangnan He, Lianghe Mei, Yangliang Ye, Zongsheng Chen, Juwen Shen, Panpan Hou, Jiangtao Guo*, Qiansen Zhang*, Huaiyu Yang*. A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nature Chemical Biology. 2024 Jan 2. doi: 10.1038/s41589-023-01515-y.（共同通讯）(IF=14.86)
Yuan Weng#, Xinyu Yang#, Qiansen Zhang#,*, Ying Chen, Yueming Xu, Chenyu Zhu, Qiong Xie, Yonghui Wang, Huaiyu Yang, Mingyao Liu, Weiqiang Lu* & Gaojie Song*. Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A2 receptors. Science China Life Sciences. 2024 Jan 31. doi: 10.1007/s11427-023-2459-8. （共同通讯和共一作者）(IF=9.1)
Heng Liu#, Maya M. Polovitskaya#, Linlin Yang*, Meiling Li, Hongyue Li, Zhen Han, Jianguo Wu, Qiansen Zhang*, Thomas J. Jentsch*, and Jun Liao*. Structural insights into anion selectivity and activation mechanism of LRRC8 volume-regulated anion channels. Cell Reports. 2023, 42.8. （共同通讯）(IF=9.9)
Qiansen Zhang#, Yimin Ren#,Yiqing Mo#, Peipei Guo#, Ping Liao#, Yuncheng Luo#, Jie Mu, Zhuo Chen, Yang Zhang, Ya Li, Linghui Yang, Daqing Liao, Jie Fu, Juwen Shen, Wei Huang, Xuewen Xu, Yanyan Guo, Lianghe Mei, Yunxia Zuo, Jin Liu, Huaiyu Yang*, Ruotian Jiang*. Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects. Cell Research. 2022, 32, 461–476. （封面论文+Research highlight报道）(IF=46.3)
Huang Chen#, Wenbo Zhou#, Aiwu Bian#, Qiansen Zhang#, Ying Miao, Xuan Yin, Jiangnan Ye, Shifen Xu, Chaowen Ti, Zhenliang Sun, Jianghua Zheng, Yihua Chen*, Mingyao Liu*, Zhengfang Yi*. Selectively targeting STAT3 using a small molecule inhibitor is a potential therapeutic strategy for pancreatic cancer. Clinical Cancer Research. 2022, CCR-22-0997. （共同第一作者）(IF=11.5)
Qiansen Zhang#, Jie Fu#, Shaoying Zhang, Peipei Guo, Shijie Liu, Juwen Shen, Jiangtao Guo, Huaiyu Yang*. ‘C-type’ closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel. Journal of Molecular Cell Biology. 2022, https://doi.org/10.1093/jmcb/mjac002. （封面论文+Research highlight报道）(IF=8.18)
Xiaoxiao Li#, Qiansen Zhang#, Peipei Guo#, Jie Fu, Lianghe Mei, Dashuai Lv, Jiangqin Wang, Dongwu Lai, Sheng Ye, Huaiyu Yang*, Jiangtao Guo*. Molecular basis for ligand activation of the human KCNQ2 channel. Cell Research. 2021, 31: 52-61. （共同第一作者）(IF=46.3)
Bei-Er Jiang#, Xingwu Jiang#, Qiansen Zhang#, Qiuwen Liang, Zi-Liang Qiu, Xiang-Bai Sun, Jun-Jie Yang, Si Chen, Chunyang Yi, Xiaolei Chai, Mingyao Liu, Li-Fang Yu*, Weiqiang Lu*, and Han-Kun Zhang*. From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis. J. Med. Chem. 2021, 64: 385–403. （共同第一作者）(IF=8.0)
Qiansen Zhang#, Pingzheng Zhou#, Zhuxi Chen, Min Li, Hualiang Jiang, ZhaobingGao*, and Huaiyu Yang*. Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating. Proc Natl Acad Sci U S A. 2013, 110(50):20093-8.(IF=12.8)
Huiying Li#, Qiansen Zhang#, Yiran Gu#, Yingyin Wu, Yamei Wang, Liren Wang, Shijie Feng, Yaqiang Hu, Yansen Zheng, Yongmei Li, Haifeng Ye, Bin Zhou, Longnian Lin, Mingyao Liu*, Huaiyu Yang*, and Dali Li*. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A. 2020, 117 (52): 33426-33435.（共同第一作者）(IF=12.8)
Wang, M.#, Zhang, Q. S.#, Jian, H., Liu, S., Li, J., Wang, A., . . . Bai, S. Role of Thermolysin in Catalytic-Controlled Self-Assembly of Fmoc-Dipeptides. CCS Chemistry. 2020，2, 317–328 (共同第一作者)(IF=11.2)
Ruoyu Wang#, Qiansen Zhang#, Yi Zhang, Hanchang Shi, Kim Truc Nguyen, and Xiaohong Zhou*. Unconventional Split Aptamers Cleaved at Functionally Essential Sites Preserve Biorecognition Capability. Analytical Chemistry, 2019, 91(24), 15811-15817. (共同第一作者) (IF=8.0)
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