张鑫 - 西湖大学

个人简介

张鑫教授2001年毕业于中国科学技术大学化学物理系；2004年获中科院大连化物所硕士学位，导师为韩克利研究员；2010年获加州理工学院化学系博士学位，导师为Shu-ou Shan教授，随后进入美国Scripps研究所做博士后研究，导师为Jeffery W. Kelly教授。2015年，张鑫获聘美国宾州州立大学化学系和生物化学与分子生物学系助理教授；2020年，张鑫晋升长聘副教授，Paul Berg Early Career讲席教授。2021年入职西湖大学，受聘化学教授，细胞生物学教授。自2022年1月起，任西湖大学工学院生物医学工程领域兼聘教授。

研究领域

张鑫课题组聚焦于生物有机化学和蛋白质生物化学的交叉领域，以“生物大分子相分离和聚集的化学生物学”为研究中心，瞄准此研究领域亟需解决的重要技术和科学问题，为基础生物学和生物医药产业提供重要科学支持

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Y. Bai, S. Zhang, H. Dong, Y. Liu, C. Liu*, X. Zhang*, “Advanced techniques for detecting protein misfolding and aggregation in cellular environments”, Chem. Rev., 2023, 123, 21, 12254-12311. S. Ye, A. P. Latham, Y. Tang, C. -H. Hsiung, J. Chen, F. Luo, Y. Liu, B. Zhang, X. Zhang*, “Micropolarity governs the structural organization of biomolecular condensates”, Nat. Chem. Biol., 2023, in press. H. Feng, Q. Zhao, B. Zhang, H. Hu, M. Liu, K. Wu, X. Li, X. Zhang*, L. Zhang*, Y. Liu*, “Enabling photo-crosslinking and photo-sensitizing properties for synthetic fluorescent protein chromophores”, Angew. Chem. Int. Ed., 2023, 62(2), e202215215. B. Shen, K. H. Jung, S. Ye, C. A. Hoelzel, C. H. Wolstenholme, H. Huang*, Y. Liu*, X. Zhang*, “A dual-functional BODIPY-based molecular rotor probe reveals different viscosity of protein aggregates in live cells”, Aggregate, 2022, e301. L. Wang, C. -H. Hsiung, X. Liu, S. Wang, A. Loredo, X. Zhang*, H. Xiao*, “Xanthone-based solvatochromic fluorophores for quantifying micropolarity of protein aggregates”, Chem. Sci., 2022, 13, 12540-12549. S. Ye, C. -H. Hsiung, Y. Tang, X. Zhang*, “Visualizing the multi-step process of protein aggregation in live cells”, Acc. Chem. Res., 2022, 55, 381–390. S. Tang, W. Wang, X. Zhang*, “Direct visualization and profiling of protein misfolding and aggregation in live cells”, Curr. Opin. Chem. Biol., 2021, 64, 116-123. S. Tang, S. Ye, X. Zhang*, “When aggregation-induced emission meets protein aggregates”, Nat. Sci. Rev., 2021, 8, nwab013. S. Ye, H. Zhang, J. Fei, C. Wolstenholme, X. Zhang*, “A general strategy to control viscosity sensitivity of molecular rotor-based fluorophores”, Angew. Chem. Int. Ed., 2021, 60, 1339-1346. C. H. Wolstenholme, H. Hu, S. Ye, B. E. Funk, D. Jain, C. -H. Hsiung, G. Ning, Y. Liu, X. Li*, X. Zhang*, “AggFluor: Fluorogenic toolbox enables direct visualization of the multi-step protein aggregation process in live cells”, J. Am. Chem. Soc., 2020, 142, 17515–17523. (Highlighted by JACS Spotlights, Protein Aggregation: It’s a Process). C. A. Hoelzel, H. Hu, C. H. Wolstenholme, B. A. Karim, K. T. Munson, K. H. Jung, Y. Liu, H. P. Yennawar, J. B. Asbury, X. Li*, X. Zhang*, “A general strategy to enhance donor-acceptor molecules using solvent-excluding substituents”, Angew. Chem. Int. Ed., 2020, 59, 4785-4792. S. H. Kim, Y. Liu, C. Hoelzel, X. Zhang*, T. H. Lee*, “Super-resolution optical lithography with DNA”, ACS Nano Letter, 2019, 19, 6035-6042. Y. Liu, C. H. Wolstenholme, G. Carter, H. Liu, H. Hu, L. S. Grainger, K. Miao, M. Fares, C. A. Hoelzel, H. Yennawar, G. Ning, M. Du, L. Bai, X. Li, X. Zhang*, “Modulation of fluorescent protein chromophores to detect protein aggregation with turn-on fluorescence”, J. Am. Chem. Soc., 2018, 140, 7381-7384. Y. Liu, M. Fares, N. P. Dunham, Z. Gao, K. Miao, X. Jiang, S. S. Bollinger, A. K. Boal, X. Zhang*, “AgHalo: A facile fluorogenic sensor to detect drug induced proteome stress”, Angew. Chem. Int. Ed., 2017, 56, 8672-8676.