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个人简介

闫志强,华东师范大学化学与分子工程学院上海分子治疗与新药创制工程技术研究中心研究员,博士生导师,本科、硕士毕业于沈阳药科大学,博士毕业于复旦大学药学院。研究方向为新型递药系统、核酸脂质纳米粒、细胞免疫治疗,重点关注新型核酸脂质纳米粒用于基因治疗及在体细胞免疫治疗等领域。在Adv Mater、ACS Nano、J Hematol Oncol、J Control Release、Chem Eng J等国内外期刊发表论文70余篇,被引2000余次,H指数29,授权发明专利20余项,主持国家自然科学基金面上项目(2项)和青年项目、国家重点研发计划子课题、上海市国际合作项目、企业委托项目等10余项,参编专著1部。任Asian J Pharm Sci和Military Med Res青年编委、中国药剂专委会青年后备委员、上海市药学会工业药剂学组组员。 教育经历 2008/9 - 2011/7,复旦大学,药剂学,博士,导师:陆伟跃 教授 2005/9 - 2008/7,沈阳药科大学,药剂学,硕士,导师:孙进、何仲贵 教授 2001/9 - 2005/7,沈阳药科大学,药物制剂,学士 工作经历 2022/12 - 今,华东师范大学,化学与分子工程学院,研究员,博士生导师 2018/12 - 2022/12,华东师范大学,化学与分子工程学院,副研究员,硕士生导师 2013/9 - 2018/12,华东师范大学,化学与分子工程学院,助理研究员 2011/7 - 2013/9,纳米技术及应用国家工程研究中心,助理研究员

研究领域

新型递药系统、核酸脂质纳米粒、细胞免疫治疗,重点关注新型核酸脂质纳米粒用于基因治疗及在体细胞免疫治疗等领域

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Wang Y, Liu Y, Liu Y, Zhong J, Wang J, Sun L, Yu L, Wang Y, Li Q*, Jin W, Yan Z*. Remodeling liver microenvironment by L-arginine loaded hollow polydopamine nanoparticles for liver cirrhosis treatment. Biomaterials, 2023, 122028. (IF=15.305) Sun L, Zhang J, Zhou JE, Wang J, Wang Z, Luo S, Wang Y, Zhu S*, Yang F, Tang J, Lu W, Wang Y, Yu L, and Yan Z*. Monitoring the in vivo siRNA release from lipid nanoparticles based on the fluorescence resonance energy transfer principle. Asian J Pharm Sci. 2023, 18: 100769. (IF = 9.273) Sun L, Zhou J, Luo T, Wang J, Kang L, Wang Y, Luo S, Wang Z, Zhou Z, Zhu J, Yu J, Yu L, Yan Z*. Nanoengineered neutrophils as cellular sonosensitizer for visual sonodynamic therapy of malignant tumors. Adv. Mater., 2022, e2109969. (IF =32.086) Zhou JE, Sun L, Jia Y, Wang Z, Luo T, Tan J, Fang X, Zhu H, Wang J, Yu L*, Yan Z*. Lipid nanoparticles produce chimeric antigen receptor T cells with interleukin-6 knockdown in vivo. J Control Release. 2022, 350: 298-307 (IF = 11.467) Zhou JE, Sun L, Liu L, Jia Y, Han Y, Shao J, Wang J, Wang Y, Yu L, Yan Z*. Hepatic macrophage targeted siRNA lipid nanoparticles treat non-alcoholic steatohepatitis. J. Control. Release, 2022, 343: 175-186 (IF = 11.467) Tan J, Jia Y, Zhou M, Fu C, Tuhin I J, Ye J, Monty M A, Xu N, Kang L, Li M, Shao J, Fang X, Zhu H, Yan L, Qu C, Xue S, Jin Z, Chen S, Huang H, Xu Y, Chen J, Miao M, Tang X, Li C, Yan Z*, Wu D*, Yu L*. Chimeric antigen receptors containing the OX40 signalling domain enhance the persistence of T cells even under repeated stimulation with multiple myeloma target cells. J. Hematol. Oncol., 2022, 15(1): 39 (IF = 23.168) Wang Y, Liu Y, Zhou J-e, Lin L, Jia C, Wang J, Yu L, Wang Y*, Yan Z*. Controllable hydrogen release for gas-assisted chemotherapy and ultrasonic imaging of drug-resistant tumors. Chem. Eng. J., 2021, 421: 129917. (IF=16.744) Zhang J, Shen H, Xu J, Liu L, Tan J, Li M, Xu N, Luo S, Wang J, Yang F, Tang J, Li Q, Wang Y, Yu L*, Yan Z*. Liver-Targeted siRNA Lipid Nanoparticles Treat Hepatic Cirrhosis by Dual Antifibrotic and Anti-inflammatory Activities. ACS Nano, 2020;14(5):6305-22. (IF=15.881) Gao L, Yu J, Liu Y, Zhou J, Sun L, Wang J, Zhu J, Peng H, Lu W, Yu L, Yan Z*, Wang Y*. Tumor-penetrating Peptide Conjugated and Doxorubicin Loaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for Tumor Theranostics. Theranostics, 2018, 7(20):4984-5000 (IF=8.537) Fan M, Li M, Gao L, Geng S, Wang J, Wang Y, Yan Z*, Yu L*. Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukaemia. J Hematol Oncol, 2017, 10(1): 151. (IF=7.333) Jia Z, Gong Y, Pi Y, Liu X, Gao L, Kang L, Wang J, Yang F, Tang J, Lu W, Li Q, Zhang W, Yan Z*, Yu L*. pPB peptide-mediated siRNA-loaded stable nucleic acid lipid nanoparticles on targeting therapy of hepatic fibrosis. Mol Pharm, 2018, 15(1): 53-62(IF=4.566) Zhou JE, Yu J, Gao L, Sun L, Peng T, Wang J, Zhu J, Lu W, Zhang L, Yan Z*, Yu L*. iNGR-Modified Liposomes for Tumor Vascular Targeting and Tumor Tissue Penetrating Delivery in the Treatment of Glioblastoma. Mol Pharm, 2017, 14(5): 1811-1820.(IF=4.556) Yan Z*, Yang Y, Wei X, Zhong J, Wei D, Liu L, Xie C, Wang F, Zhang L, Lu W*, He D. Tumor-penetrating Peptide mediation: an effective strategy for improving the transport of liposomes in tumor tissue. Mol Pharm, 2014, 11(1): 218-225.(IF=4.384) 杨一祎, 闫志强*, 钟建, 何丹农*, 陆伟跃, 多肽介导的肿瘤靶向纳米递药系统, 化学进展, 2013, 25(06):1052-1060. Yan Z, Wang F, Wen Z, Zhan C, Feng L, Liu Y, Wei X, Xie C, Lu W*. LyP-1-conjugated PEGylated liposomes: a carrier system for targeted therapy of lymphatic metastatic tumor. J Control Release, 2012, 157(1): 118-125.(IF=7.633)

学术兼职

Asian J Pharm Sci青年编委 Military Med Res青年编委 中国药剂专委会青年后备委员 上海市药学会工业药剂学组组员

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