董素珍 - 华东师范大学 - 化学与分子工程学院

研究领域

抗肿瘤小分子化合物的筛选及其抗肿瘤机制研究肽脱甲酰基酶及吲哚胺2,3加氧酶新型抑制剂的筛选及其抗肿瘤作用研究阿尔茨海默病分子病理机制及相关化合物作用研究

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Hu X , He J, Dong S, Zhao Q, Yu J, Zhou J. Regioselective Markovnikov hydrodifluoroalkylation of alkenes using difluoroenoxysilanes. Nature Communication. 2020. 11:5500. Han, Y, Ren, Z, Wu, Y, Chen, Y, Cui, Z, Zhu, T, Ma, M, Du, Y, and Dong, S*,Pharmacological activation of the p53 pathway by a new compound CYZ2017 exerts anti-tumor effects.Biochem Biophys Res Commun. 2020, 533: 1069-1075. Ji, J, Sajjad, F, You, Q, Xing, D, Fan, H, Reddy, AGK, Hu, W*, and Dong, S*,Synthesis and biological evaluation of substituted pyrrolidines and pyrroles as potential anticancer agents.Arch Pharm (Weinheim).2020, e2000136. Hu, L#, Cai, X#, Dong, S#, Zhen Y, Hu J, Wang, S, Jiang J, Huang J, Han Y, Qian Y*, Yuan Y*, Hu, W, Synthesis and Anti-cancer Activity of Novel Actinonin Derivatives as HsPDF Inhibitors. Journal of Medicine Chemistry. 2020, 63, (13): 6959–6978. Yu, Y., Han, Y., Zhang, F., Gao, Z., Zhu, T., Dong, S.*, and Ma, M.*, Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors. J Med Chem,2020.63, 6, 3028-3046 You, Q., Gong Q., Han Y.Q., P R.i, Du Y., and Dong S.*, Role of miR-124 in the regulation of retinoic acid-induced Neuro-2A cell differentiation. Neural Regen Res, 2020. 15(6): p. 1133-1139. Song, L., Ni, D., Jia, S., Pi, R., Dong, S., Yang, F., Tang, J., and Liu, S., C(sp2)-H Bond Multiple Functionalization in Air for Construction of Tetrahydrocarbazoles with Continuous Quaternary Carbons and Polycyclic Diversification. Org Lett,2020. 22(5): p. 1846-1851. He, L., Bao J., Yang, Y. Dong S., Zhang, L. Qi Y., and. Zhang J.Z.H, Study of SHMT2 Inhibitors and Their Binding Mechanism by Computational Alanine Scanning. J Chem Inf Model,2019. 59(9): p. 3871-3878. Niu, L., Pi R., Dong S., and Liu S., Aromatic C-H Bond Functionalized via Zwitterion Intermediates to Construct Bioxindole Containing Continuous Quaternary Carbons. J Org Chem,2019. 84(23): p. 15192-15200. Li, Z., Jia, K., Duan, Y., Wang, D., Zhou, Z., and Dong, S.*,Xanomeline derivative EUK1001 attenuates Alzheimer's disease pathology in a triple transgenic mouse model.Molecular Medicine Reports, 2017. 16(5): 7835-7840. Jia, K., Lv, X., Xing, D., Che, J., Liu, D., Thumar, N.J., Dong, S.*, and Hu, W.*,Synthesis and biological evaluation of 3-amino-3-hydroxymethyloxindoles as potential anti-cancer agents.Rsc Advances, 2017. 7(38): 23265-23271. Lei, R., Wu, Y., Dong, S., Jia, K., Liu, S., and Hu, W.,A Diastereoselective Multicomponent Reaction for Construction of Alkynylamide-Substituted alpha,beta-Diamino Acid Derivatives To Hunt Hits.Journal of Organic Chemistry, 2017. 82(6): 2862-2869. Jing, C., Li, Z., Jia, K., Chen, C., Liu, X., Wang, B., Hu, W., Li, J., Zhu, T.*, and Dong, S.*,Discovery of Bisindole as a Novel Scaffold for Protein Tyrosine Phosphatase 1B Inhibitors.Archiv Der Pharmazie,2017. 350(1). Dong, S., Lei, Y., Jia, S., Gao, L., Li, J., Zhu, T., Liu, S., and Hu, W.,Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.Bioorganic & Medicinal Chemistry Letters, 2017. 27(4): 1105-1108. Wang, X., Dong, S., Feng, D., Chen, Y., Ma, M., and Hu, W.*,Synthesis and biological activity evaluation of dolastatin 10 analogues with N-terminal modifications.Tetrahedron, 2017. 73(16): 2255-2266. Wang, X., Ding, X., Nan, L., Wang, Y., Wang, J., Yan, Z., Zhang, W., Sun, J., Zhu, W., Ni, B., Dong, S.*, and Yu, L.*,Investigation of the roles of exosomes in colorectal cancer liver metastasis.Oncology Reports, 2015. 33(5): 2445-2453. Duan, Y., Zhang, R., Zhang, M., Sun, L., Dong, S., Wang, G., Zhang, J., and Zhao, Z.,Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus.Neural Regeneration Research, 2013. 8(25): 2379-2388. Zhang, X., Gong, Q., Zhang, S., Wang, L., Hu, Y., Shen, H., and Dong, S.*,3- 3-(3-florophenyl-2-propyn-1-ylthio)-1, 2, 5-thiadiazol-4-yl -1, 2, 5, 6-tetrahydro-1-methylpyridine oxalate, a novel xanomeline derivative, improves neural cells proliferation and survival in adult mice.Neural Regeneration Research, 2012. 7(1): 24-30. Xu, Z.#, Dong, S.#, Du, D., Jiang, N., Sun, P., Wang, H., Yin, L., Zhang, X., Cao, X., Zhen, X., and Hu, Y.*,Generation and characterization of hD(5) and C-terminal Mutant hD(5m) transgenic rats.Brain Research, 2012. 1448: 27-41. Lu, X., Zhang, N., Meng, B., Dong, S., and Hu, Y.*,Involvement of GPR12 in the regulation of cell proliferation and survival.Molecular and Cellular Biochemistry, 2012. 366(1-2): 101-110. Lu, X., Zhang, N., Dong, S., and Hu, Y.,Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells.Brain Research Bulletin, 2012. 87(1): 30-36. Duan, Y., Dong, S., Gu, F., Hu, Y., and Zhao, Z.*,Advances in the pathogenesis of Alzheimer's disease: focusing on tau-mediated neurodegeneration.Translational neurodegeneration, 2012. 1(1): 24-24. Dong, S., Zeng, Q., Mitchell, E.S., Xiu, J., Duan, Y., Li, C., Tiwari, J.K., Hu, Y., Cao, X., and Zhao, Z.*,Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity.Plos One, 2012. 7(2). Dong, S., Duan, Y., Hu, Y., and Zhao, Z.*,Advances in the pathogenesis of Alzheimer's disease: a re-evaluation of amyloid cascade hypothesis.Translational neurodegeneration, 2012. 1(1): 18-18. Li, C., Dong, S., Wang, H., and Hu, Y.*, Microarray analysis of gene expression changes in the brains of NR2B-induced memory-enhanced mice. Neuroscience, 2011. 197: 121-131. Wu, P., Shen, Q., Dong, S., Xu, Z., Tsien, J.Z., and Hu, Y.*,Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice.Neurobiology of Aging, 2008. 29(10): 1502-1511. Sun, Q., Wei, X., Feng, J., Zhang, R., Shen, Q., Dong, J., Jin, Y., Dong, S., Li, H., and Hu, Y.*,Involvement of insulin-like growth factor-insulin receptor signal pathway in the transgenic mouse model of medulloblastoma.Cancer Science, 2008. 99(2): 234-240. Dong, S., Li, C., Wu, P., Tsien, J.Z., and Hu, Y.*,Environment enrichment rescues the neurodegenerative phenotypes in presenilins-deficient mice.European Journal of Neuroscience, 2007. 26(1): 101-112. Sun, Q., Feng, J., Wei, X.-L., Zhang, R., Dong, S., Shen, Q., Dong, J., Li, H., and Hu, Y.*,Generation and characterization of a transgenic mouse model for pancreatic cancer.World Journal of Gastroenterology, 2006. 12(17): 2785-2788. Fang, L., Zhang, M., Li, C., Dong, S., and Hu, Y.*,Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.Neuroscience Letters, 2006. 404(1-2): 148-153. Bi, C., Cui, Y., Mao, Y., Dong, S., Zhang, J., and Sun, X.*,The effect of early auditory deprivation on the age-dependent expression pattern of NR2B mRNA in rat auditory cortex.Brain Research, 2006. 1110: 30-38. Mei, B., Li, C., Dong, S., Jiang, C., Wang, H., and Hu, Y.*,Distinct gene expression profiles in hippocampus and amygdala after fear conditioning.Brain Research Bulletin, 2005. 67(1-2): 1-12.