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个人简介

姓名:杨坤龙 学位:博士 职称:副教授、硕士生导师 主要工作业绩: 围绕黄曲霉相关研究在国内外学术期刊发表论文40余篇,以第一或通讯作者身份在J Hazard Mater、J Agric Food Chem、Environ Microbiol、Food Frontiers、Virulence、Appl Microbiol Biotechnol等期刊上发表学术论文21篇(中科院SCI二区及以上论文15篇,Top-SCI 6篇,ESI高被引1篇)。论文总被引1400余次,单篇引用次数50次以上的10篇,h-index值为24。申请国家发明专利6项,授权1项。先后主持国家自然科学基金青年项目,江苏省自然科学基金青年项目、江苏省高校面上项目,徐州市科技计划项目等。曾获中国商业联合会科学技术奖一等奖(第7完成人)、江苏省高等学校科学技术研究成果奖二等奖(第4完成人)、徐州市优秀自然科学论文二等奖(第1完成人)、徐州市发明协会科学技术奖二等奖(第5完成人)等;指导学生获得全国大学生生命科学竞赛二等奖2项、三等奖2项、江苏师范大学优秀本科生毕业论文(2020年、2023年)。入选江苏省“双创计划”科技副总、江苏师范大学青年英才“苗圃计划”。 教育经历: 2016.11-2017.11 美国威斯康辛大学麦迪逊分校,病原微生物,联合培养博士,导师:Nancy P. Keller 2013.09-2017.12 福建农林大学,生物化学与分子生物学,博士 2011.09-2013.07 福建农林大学,生物工程,硕士 2007.09-2011.07 福建农林大学,生物科学(基地班),学士 工作经历: 2022.07 - 至今 江苏师范大学,生物医药与食品系,副教授 2018.07-2022.07 江苏师范大学,生物医药与食品系,讲师 2020.01-2020.12 美国威斯康辛大学麦迪逊分校,病原微生物

研究领域

1. 黄曲霉基因功能研究、一氧化氮信号、金属铜代谢、cAMP信号途径对黄曲霉形态发生、黄曲霉毒素产生和黄曲霉致病的调控机制研究。 2. 黄曲霉生物防控。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Kunlong Yang*, Yue Luo, Tongzheng Sun, Han Qiu, Qingru Geng, Yongxin Li, Man Liu, Nancy P. Keller, Fengqin Song*, Jun Tian*. Nitric Oxide-mediated regulation of Aspergillus flavus asexual development by targeting TCA cycle and mitochondrial function. Journal of Hazardous Materials, 2024, 471, 134385. (IF 13.6,一区Top) 2. Tongzheng Sun†, Ninghui Zhang†, Yue Luo†, Han Qiu, Qingru Geng, Yongxin Li, Xue Peng, Fengqin Song*, Jun Tian*, Kunlong Yang*. p-Anisaldehyde suppresses Aspergillus flavus infection and aflatoxin biosynthesis via targeting cell structure and Ap1-regulatory antioxidant system. 2024, Food Frontiers, 1-18. (IF 9.9, 二区) 3. Kunlong Yang†, Qingru Geng†, Yue Luo, Rui Xie, Tongzheng Sun, Zhen Wang, Ling Qin, Wei Zhao, Man Liu, Yongxin Li, Jun Tian*. Dysfunction of FadA-cAMP signaling decreases Aspergillus flavus resistance to antimicrobial natural preservative Perillaldehyde and AFB1 biosynthesis. Environmental Microbiology, 2022, 24(3):1590-1607. (IF 5.476, 二区Top,高被引) 4. Kunlong Yang, Jun Tian, Nancy P. Keller*. Post-translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review. Environmental Microbiology, 2022, 24(7):2857-2881. (IF 5.476, 二区Top) 5. Kunlong Yang†, Yinghang Liu†, Sen Wang, Lianghuan Wu, Rui Xie, Huahui Lan, Opemipo Esther Fasoyin, Yu Wang, Shihua Wang*. The cyclase-associated protein Cap with multi-domain contributes to mycotoxin biosynthesis and fungal virulence in Aspergillus flavus. Journal of Agricultural and Food Chemistry, 2019, 67:4200-4213. (IF 6.1, 一区Top) 6. Kunlong Yang, Yana Shadkchan, Joanna Tannous, Julio Landero Figueroa, Philipp Wiemann, Nir Osherov, Shihua Wang*, Nancy P. Keller*. Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus. Virulence, 2018, 1496774. (IF 5.2, 一区Top) 7. Kunlong Yang†, Qingru Geng†, Fengqin Song†, Xiaona He, Tianran Hu, Shihua Wang *, Jun Tian *. Transcriptome Sequencing Revealed an Inhibitory Mechanism of Aspergillus flavus Asexual Development and Aflatoxin Metabolism by Soy-Fermenting Non-Aflatoxigenic Aspergillus. International Journal of Molecular Sciences, 2020, 21 (19), 6994. (IF 5.923, 二区) 8. Kunlong Yang†, Yinghang Liu†, Linlin Liang, Zhenguo Li, Qiuping Qin, Xinyi Nie, Shihua Wang*. The high-affinity phosphodiesterase PdeH regulates development and aflatoxin biosynthesis in Aspergillus flavus. Fungal Genetics and Biology, 2017, 101:7-19. (IF 3.072,三区) 9. Kunlong Yang†, Qiuping Qin†, Yinghang Liu, Limei Zhang, Linlin Liang, Huahui Lan, Chihao Chen, Yunchao You, Feng Zhang, Shihua Wang*. Adenylate Cyclase AcyA Regulates Development, Aflatoxin Biosynthesis and Fungal Virulence in Aspergillus flavus. Frontiers in Cellular and Infection Microbiology, 2016, 6:190. (IF 5.218, 二区) 10. Kunlong Yang†, Linlin Liang†, Fanlei Ran, Yinghang Liu, Zhenguo Li, Huahui Lan, Peili Gao, Zhenhong Zhuang, Feng Zhang, Xinyi Nie, Shimuye Kalayu Yirga, Shihua Wang*. The DmtA methyltransferase contributes to Aspergillus flavus conidiation, sclerotial production, aflatoxin biosynthesis and virulence. Scientific Reports. 2016, 6: 23259. (IF 5.228, 三区) 11. Kunlong Yang, Zhenhong Zhuang, Feng Zhang, Fengqin Song, Hong Zhong, Fanlei Ran, Song Yu, Gaopo Xu, Faxiu Lan, Shihua Wang*. Inhibition of aflatoxin metabolism and growth of Aspergillus flavus in liquid culture by a DNA methylation inhibitor. Food Additives & Contaminants: Part A, 2015, 32 (4): 554-563. (IF 1.802, 三区) 12. Fengqin Song†, Qingru Geng†, Xuewei Wang, Xiaoqing Gao, Xiaona He, Wei Zhao, Huahui Lan, Jun Tian,*, Kunlong Yang*, and Shihua Wang*. Gas Chromatography–Mass Spectrometry Profiling of Volatile Compounds Reveals Metabolic Changes in a Non-Aflatoxigenic Aspergillus flavus Induced by 5-Azacytidine, 2020, Toxins, 12:57. (共同通讯作者, IF 4.546,二区) 13. Chao Pan†, Yong-Xin Li†, Kunlong Yang†, Erhunmwunsee Famous, Yan Ma, Xiaona He, Qingru Geng, Man Liu*, and Jun Tian*. The Molecular Mechanism of Perillaldehyde Inducing Cell Death in Aspergillus flavus by Inhibiting Energy Metabolism Revealed by Transcriptome Sequencing, 2020, International Journal of Molecular sciences, 21, 1518. (共同第一作者, IF 5.923, 二区) 14. Zhen Wang†, Kunlong Yang†, Lei Chen, Rui Yan, Su Qu, Yong-xin Li, Man Liu*, Hong Zeng*, Jun Tian*. Activities of Nerol, a natural plant active ingredient, against Candida albicans in vitro and in vivo. Applied Microbiology and Biotechnology, 2020, 104(11):5039-5052. (共同第一作者, IF 4.813, 二区) 15. Su Qu†, Kunlong Yang†, Lei Chen†, Man Liu, Qingru Geng, Xiaona He, Yongxin Li, Yongguo Liu* and Jun Tian*. Cinnamaldehyde, a Promising Natural Preservative Against Aspergillus flavus. Frontiers in Microbiology, 2019, 10: 02895. (共同第一作者, IF 4.259, 二区Top) 16. Opemipo Esther Fasoyin†, Kunlong Yang†, Mengguang Qiu, Bin Wang, Sen Wang and Shihua Wang. Regulation of Morphology, Aflatoxin Production, and Virulence of Aspergillus flavus by the Major Nitrogen Regulatory Gene areA. Toxins, 2019;11(12):718. (共同第一作者, IF 3.895, 二区) 17. Yinghang Liu†, Kunlong Yang†*, Qiuping Qin, Guinan Lin, Zhangling Xu, Huahui Lan, Jun Yuan, Feng Zhang and Shihua Wang*. G protein α subunit GpaB is required for asexual development and aflatoxin biosynthesis by regulating cAMP signaling in Aspergillus flavus. Toxins, 2018, 10, 117. (共同第一作者, 并列通讯,IF 3.273,二区) 18. Linlin Liang†, Yinghang Liu†, Kunlong Yang†, Guinan Lin, Zhangling Xu, Huahui Lan, Xiuna Wang, Shihua Wang*. The putative histone methyltransferase DOT1 regulates aflatoxin and pathogenicity attributes in Aspergillus flavus. Toxins, 2017, 9 (7): 232. (共同第一作者, IF 3.030,二区) 19. 孙统政†, 王娜†, 田俊, 杨坤龙*.黄曲霉毒素B1检测与脱毒方法最新研究进展. 江苏农业学报 2021, 37 (03), 789-799. (核心期刊,通讯作者) 20. 宋凤琴, 高晓庆, 梁林林, 王雨萱, 杨坤龙*. Homeobox转录因子对黄曲霉生长和毒素合成的影响. 菌物学报, 2020, 39(3): 566-580.(核心期刊,通讯作者) 21. 耿青如, 杨飞洋, 王雨荷, 车雨微, 杨坤龙*.丝状真菌次级代谢产物的功能与合成调控研究进展, 菌物学报, 2020, 39(3): 539-547. (核心期刊,通讯作者) 【主要合作论文】 1. Ahai Chen, Na Liu, Yiyi Ren, Xingmin Han, Chenghui Xu, Siqi Wu, Chao Liu, Hao Qi, Kunlong Yang, Xiao Liu, Zhonghua Ma, Yun Chen*. The STRIPAK complex orchestrates cell wall integrity signalling to govern the fungal development and virulence of Fusarium graminearum. Mol Plant Pathol, 2023, 24(9):1139-1153. (IF 5.5199, 一区Top) 2. Chao Pan, Kunlong Yang, Famous Erhunmwunsee, Yong-Xin Li, Man Liu, Shenyuan Pan, Dongjing Yang, Guoquan Lu, Daifu Ma, Jun Tian*. Inhibitory effect of cinnamaldehyde on Fusarium solani and its application in postharvest preservation of sweet potato. Food Chemistry, 2023, 408:135213. (IF 9.2306,一区Top, 高被引) 3. Chao Pan, Kunlong Yang, Famous Erhunmwunsee, Bo Wang, Dongjing Yang, Guoquan Lu, Man Liu, Yongxin Li, Jun Tian*. Antifungal Activity of Perillaldehyde on Fusarium solani and Its Control Effect on Postharvest Decay of Sweet Potatoes. Journal of Fungi, 2023, 9(2):257. (IF 5.7238,二区) 4. SenWang#, YuWang#, YinghangLiu#, LinLiu, Jinyu Li, Kunlong Yang, Mengxin Liu, Wanlin Zeng, Ling Qin, Ranxun Lin, Xinyi Nie, Longguang Jiang, ShihuaWang*. The Regulatory Role of the Aspergillus flavus Core Retromer Complex in Aflatoxin Metabolism. Journal of Biological Chemistry, 2022, 298(7): 102120. (IF 5.1571, 二区TOP) 5. Yong-Xin Li*, Famous Erhunmwunsee, Man Liu, Kunlong Yang, Weifa Zheng, Jun Tian*. Antimicrobial mechanisms of spice essential oils and application in food industry. Food Chemistry, 2022, 382:132312. (IF 7.514, 一区Top, 高被引) 6. Lei Chen†, Fei Wang†, Su Qu†, Xiaona He, Yongxin Zhu, Yi Zhou, Kunlong Yang, Yong-Xin Li, Man Liu, Xue Peng, Jun Tian*. Therapeutic Potential of Perillaldehyde in Ameliorating Vulvovaginal Candidiasis by Reducing Vaginal Oxidative Stress and Apoptosis. Antioxidants, 2022, 11 (2), 178. (IF 6.3132, 二区Top) 7. Famous Erhunmwunsee, Chao Pan, Kunlong Yang, Yong-Xin Li, Man Liu*, Jun Tian*. Recent development in biological activities and safety concerns of perillaldehyde from perilla plants: A review. Critical Reviews in Food Scienceand Nutrition, 2021, 1900060. (IF 11.1763, 一区Top) 8. Jeffrey M. Skerker, Kaila M. Pianalto, Stephen J. Mondo, Kunlong Yang, Adam P. Arkin, Nancy P. Keller, Igor V. Grigoriev, N. Louise Louise Glass*. Chromosome assembled and annotated genome sequence of Aspergillus flavusNRRL 3357. G3, 2021, 11(8): jkab213. (IF 3.154, 三区) 9. Lei Chen, Su Qu, Kunlong Yang, Man Liu, Yong-xin Li, Nancy P. Keller, Xiaobin Zeng, Jun Tian*. Perillaldehyde: a promising antifungal agent to treat oropharyngeal candidiasis. Biochemical Pharmacology, 2020, 114201. (IF 5.858, 二区TOP) 10. Xuezhi Li†, Man Liu†*, Tinggong Huang, Kunlong Yang, Sihan Zhou, Yongxin Li, Jun Tian*. Antifungal effect of nerol via transcriptome analysis and cell growth repression in sweet potato spoilage fungi Ceratocystis fimbriata. Postharvest Biology and Technology, 2021, 171. (IF 5.537, 一区TOP) 11. Ling Qin, Ding Li, Jiaru Zhao, Guang Y., Yinchun Wang, Kunlong Yang, Elisabeth Tumukunde, Shihua Wang* and Jun Yuan*. The membrane mucin Msb2 regulates aflatoxin biosynthesis and pathogenicity in fungus Aspergillus flavus. Microbial Biotechnology, 2020, 14(2):628-642. (IF 5.813, 二区) 12. Yongxin Li, Chi Zhang, Shenyuan Pan, Lei Chen, Man Liu, Kunlong Yang, Xiaobin Zeng*, JunTian*. Analysis of chemical components and biological activities of essential oils from black and white pepper (Piper nigrum L.) in five provinces of southern China. LWT - Food Scienceand Technology, 2020, 117: 108644. (IF 4.952, 一区Top) 13. Yu Wang†, Sen Wang†, Xinyi Ni, Kunlong Yang, Peng Xu, Xiuna Wang, Mengxin Liu, Yongshuai Yang, Zhuo Chen, Shihua Wang*. Molecular and structural basis of nucleoside diphosphate kinase-mediated regulation of spore and sclerotia development in the fungus Aspergillus flavus. The Journal of biological chemistry, 2019, 294(33), 12415–12431. (IF 4.106, 二区TOP) 14. Huahui Lan#, Lianghuan Wu#, Ruilin Sun, Nancy P. Keller, Kunlong Yang, Liuqing Ye, Shuibin He, Feng Zhang, Shihua Wang. The HosA histone deacetylase regulates aflatoxin biosynthesis through direct regulation of aflatoxin cluster genes. Molecular Plant-Microbe Interactions, 2019, 32(9):1210-1228. (IF 3.649, 三区)

学术兼职

1. Journal of Fungi、Frontiers in Cellular and Infection Microbiology客座编辑 2. Frontiers in Cellular and Infection Microbiology和Frontiers in Fungal Biology评审编辑 3. Environmental Microbiology、mSphere、Journal of Fungi、Food Research International、Fungal Genetics and Biology、Frontiers in Microbiology、BMC Microbiology等10余个学术期刊审稿人

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