研究领域
LC-MS-based metabolomics
Drug metabolism and pharmacokinetics
Drug-induced liver injury
Blood testis barrrier
近期论文
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Xing Liu, Yuanfu Lu, Xinfu Guan, Bingning Dong, Hemantkumar Chavan, Jin Wang, Yiqing Zhang, Partha Krishnamurthy, Feng Li* "Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism." Biochem Pharmacol.. 2015 Sep 1;97(1):111-121. Pubmed PMID: 26212543
Feng Li, Jie Lu, Jie Cheng, Laiyou Wang, Tsutomu Matsubara, Ivan Csanaky, Curtis D. Klaassen, Frank J. Gonzalez, Xiaochao Ma "Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy." Nat. Med.. 2013;19:418-420. Pubmed PMID: 23475203
Xing Liu, Yuan-Fu Lu, Xinfu Guan, Mingkun Zhao, Jin Wang, Feng Li* "Characterizing novel metabolic pathways of melatonin receptors agonist agomelatine using metabolomics approaches." Biochem Pharmacol.. 2016 Jun 1;109:70-82. Pubmed PMID: 27021842
Michelle L Spruill, Mirjana Maletic-Savatic, Howard Martin, Feng Li*, Xinli Liu* "Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging." Biochem Pharmacol. 2022;201:115080.
Xuan Qin, John M Hakenjos , Kevin R MacKenzie, Mercedes Barzi, Jin Wang, Sung Yun Jung, Martin M Matzuk, Feng Li "Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice." Drug Metab Dispos. 2022;50:128-139. Pubmed PMID: 34785568
Mercedes Barzi, Francis P Pankowicz, Barry Zorman, Xing Liu, Xavier Legras, Diane Yang, Malgorzata Borowiak, Beatrice Bissig-Choisat, Pavel Sumazin, Feng Li, Karl-Dimiter Bissig "A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism." Nat Commun. 2017;8:39. Pubmed PMID: 28659616