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1992.081995.08 第二军医大学长征医院药学部从事新药研究和申报工作,获“若静滴液”、“酮康唑乳膏”、“胸腺肽肠溶胶囊”新药证书 1998.122001.04第二军医大学长征医院药学部制剂研究室负责人 从事中药制剂开发和天然药物研究 2001.052004.12第二军医大学长征医院药学部副主任药师,荣立个人三等功 2005.012012.12第二军医大学长征医院药学部副主任、制剂室负责人 2011.092012.12第二军医大学海洋生物技术与海洋药物研究所副所长 2013.01至今 上海交通大学医学院附属仁济医院药学部主任 上海交通大学医学院海洋药物研究中心主任,特聘教授

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Yang F#, Sang M, Lu J.-R, Zhao H.-M, Zou Y, Wu W, Yu Y, Liu Y.-W, Ma W, Zhang Y, Zhang W, Hou-Wen Lin*. Somalactams A–D: Anti‐inflammatory Macrolide Lactams with Unique Ring Systems from an Arctic Actinomycete Strain. Angew Chem Int Ed. 2023, anie. 202218085. (IF=16.823) Qi Yang#, Jackson K B Cahn , Jörn Piel, Yue-Fan Song, Wei Zhang*, Hou-Wen Lin*. Marine Sponge Endosymbionts: Structural and Functional Specificity of the Microbiome within Euryspongia arenaria Cells. Microbiology Spectrum, 2022, 10(3), e0229621. (IF=9.043) Yi-Dan Yan#, Ying Zhao, Chi Zhang, Jie Fu, Ying-Jie Su, Xiang-Li Cui, Er-Li Ma, Bing-Long Liu, Zhi-Chun Gu*, Hou-Wen Lin*. Toxicity spectrum of immunotherapy in advanced lung cancer: A safety analysis from clinical trials and a pharmacovigilance system. EClinicalMedicine. 2022, 50, 101535. (IF=17.033) Mengyu Tao#,Fan Sun,Juan Wang,Yujing Wang,Hongrui Zhu,Meiqi Chen,Liyun Liu, Li Liu,Houwen Lin#,Xia Wu#;Developing patient-derived organoids to predict PARP inhibitor response and explore resistance overcoming strategies in ovarian cancer,pharmacological research,2022,179(IF=10.334) Ying Wu#, Zong-Mei Wu, Shuai-Shuai Zhang, Li-Yun Liu, Fan Sun, Wei-Hua Jiao, Shu-Ping Wang,*and Hou-Wen Lin*;Axinellasins A−D, Immunosuppressive CycloheptapeptideDiastereomers, Discovered via a Precursor Ion Scanning−Supercritical Fluid Chromatography Strategy from the MarineSponge Axinella species,Organic Letters. 2022,24:934-938 (IF=6.732) Liting Wang#; Qing Shen#; Hongze Liao*; Hao Fu; Qi Wang; Jian Yu; Wei Zhang; Chuanrong Chen; Yang Dong; Xupeng Yang; Qianqian Guo; Jiali Zhang; Jian Zhang; Wei Zhang; Hou-Wen Lin*; Yourong Duan*, Multi-Arm PEG/Peptidomimetic Conjugate Inhibitors of DR6/APP Interaction Block Hematogenous Tumor Cell Extravasation, Advance Science, 2021, 2003558. (IF=16.801) Yijia Cheng a, #, Nannan Chen b, #, Jing Li c, Jun-Cheng Su b, Jingya Yang c, Cui-Xian Zhang a, *, Hou-Wen Lin b, *, Yongjun Zhou b, *. Antimicrobial Chlorinated Carbazole Alkaloids from the Sponge-Associated Actinomycete Streptomyces diacarni LHW51701,Chinese Journal of Chemistry, 2021, 39:1188-1192. (IF=6) Bo Liu, Shuping Wang, Changhao Bian, Hongze Liao* and Hou-Wen Lin*. Divergent Syntheses of Pyridoacridine Alkaloids via PalladiumCatalyzed Reductive Cyclization with Nitro-Biarene. Chinese Journal of Chemistry, 2021,39, 1951-1910(IF=6) Jia-Bao Sun*, Li-Li Hong*, Ru-Yi Shang, Hong-Yan Liu, Lu Zhang, Li-Yun Liu, Lu Zhao, Wei Zhang, Fan Sun, Wei-Hua Jiao, Hou-Wen Lin*. Dysiscalarones A-E, scalarane sesterterpenoids with nitric oxide production inhibitory activity from marine sponge Dysidea granulosa . Bioorganic Chemistry, 2021,111,104791 (IF=5.275) Ying Wu#, Hongze Liao#, Li-Yun Liu, Fan Sun, Hai-Feng Chen, Wei-Hua Jiao, Hong-Rui Zhu, Fan Yang, Gang Huang, De-Quan Zeng, Mi Zhou, Shu-Ping Wang,* and Hou-Wen Lin*. Phakefustatins A−C: Kynurenine-Bearing Cycloheptapeptides as RXRα Modulators from the Marine Sponge Phakellia fusca. Org Lett. 2020, 22(17):6703-6708(IF=6.555) Wei-Hua Jiao,* Qi-Hang Xu, Guang-Bo Ge, Ru-Yi Shang, Hong-Rui Zhu, Hong-Yan Liu, Jie Cui, Fan Sun, and Hou-Wen Lin*. Flavipesides A−C, PKS-NRPS Hybrids as Pancreatic Lipase Inhibitors from a Marine Sponge Symbiotic Fungus Aspergillus flavipes 164013. Org Lett. 2020, 22(5):1825-1829(IF=6.555) Wei-Hua Jiao, * Qi-Hang Xu, Jie Cui, Ru-Yi Shang, Yun Zhang, Jia-Bao Sun, Qi Yang, Ke-Chun Liub and Hou-Wen Lin*. Spiroetherones A and B, sesquiterpene naphthoquinones, as angiogenesis inhibitors from the marine sponge Dysidea etheria. Organic Chemistry Frontiers, 2020, 7, 368-373(IF=5.934) Yu-han Gui, Wei-hua Jiao*, Mi Zhou, Yun Zhang, De-quan Zeng, Hong-rui Zhu, Ke-chun Liu, Fan Sun, Hai-feng Chen, Hou-Wen Lin*. Septosones A−C, in Vivo Anti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from the Marine Sponge Dysidea septosa. Organic Letters. 2019,21:767-770 (IF=6.732) Yuan Gao#, Fan Yang#, Fan Sun, Lei Liu, Bo Liu, Shu-ping Wang, Chun-wei Cheng, Hong-ze Liao*, Hou-Wen Lin*. Total Synthesis of Aaptamine, Demethyloxyaaptamine, and Their 3‑Alkylamino Derivatives. Organic Letters. 2019,21:1430-1433 (IF=6.732) Wei-Hua Jiao, Bao-Hui Cheng, Guo-Dong Chen, Guo-Hua Shi, Jing Li, Tian-Yong Hu, Hou-Wen Lin*. Dysiarenone, a Dimeric C21 Meroterpenoid with Inhibition of COX-2 Expression from the Marine Sponge Dysidea arenaria. Organic Letters. 2018, 20 (10): 3092–3095 (IF=6.732) Wei Wu, Li-yun Liu, Hong-rui Zhu, Ya-ting Sun, Ying Wu, Hong-ze Liao, Yu-han Gui, Lei Li, Lei Liu, Fan Sun*, Hou-Wen Lin *. Butyrolactone-I,an efficient α‑glucosidase inhibitor, improves Type 2 Diabetes with potent TNF-α-lowering properties through modulating gut microbiota in db/db mice. FASEB J. 2019 Nov;33 (11):12616-12629. (IF: 5.4) Yong-jun Zhou, Xiao Lin, Chunmin Xu, Yao-yao Shen, Shu-ping Wang, Hong-ze Liao, Lei Li, Hai Deng*, Hou-Wen Lin*. Investigation of Penicillin Binding Protein(PBP)-like Peptide Cyclase and Hydrolase in Surugamide Non-ribosomal Peptide Biosynthesis. Cell Chemical Biology. 2019, 26, 737-744 (IF=5.592)

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