熊二虎 - 湖南师范大学 - 化学化工学院

个人简介

二虎，“潇湘学者”特聘教授，硕士生导师，湖南省青年科技人才-荷尖人才(2022年)，湖南省化学化工学会第十九届青年化学化工奖(2023年)，湖南省湘江新区青年科技工作者联合会理事(2024年)， J. Anal. Test.期刊青年编委(2024年)。2018年10月博士毕业于湖南大学化学专业（导师：陈金华教授），2016年9月-2018年9月国家公派到美国德克萨斯大学奥斯汀分校进行博士联合培养（导师：Andrew D. Ellington教授），2019年3月-2022年2月在华南师范大学生命科学学院工作，2022年3月加入到湖南师范大学化学化工学院。目前主持国家和省部级项目多项，授权中国和美国发明专利各1件，申请中国专利5件。近年来，共发表学术论文40余篇，其中以第一/通讯作者身份在Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Nano等国际权威期刊上发表论文25篇，5篇ESI高被引论文，2篇热点论文。研究成果发表后，受到国内外相关领域著名专家和学者的广泛关注，并在Chem. Rev., Chem. Soc. Rev., Nat. Biomed. Eng.等国际权威期刊上给予大篇幅引用和肯定性评价。

研究领域

核酸分子体外诊断技术、CRISPR系统基因编辑技术、可视化检测体系研究、纳米生物探针构建等领域

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

P. F. Liu, Y. T. Lin, X. H. Zhuo, J. Y. Zeng, B. L. Chen, Z. Zou, G. H. Liu, E. H. Xiong*, R. H. Yang*. Universal crRNA Acylation Strategy for Robust Photo-Initiated One-Pot CRISPR-Cas12a Nucleic Acid Diagnostics. Angew. Chem. Int. Ed. 2024, 10.1002/anie.202401486. E. H. Xiong, P. F. Liu, R. J. Deng, K. X. Zhang, R. H. Yang*, J. H. Li*. Recent Advances in Enzyme-Free and Enzyme-Mediated Single-Nucleotide Variation Assay in Vitro. Natl. Sci. Rev. 2024, 11, 10.1093/nsr/nwae118. Z. Zou*, S. L. Pan, Q. Xue, T. Chen, Z. Y. Huang, B. Qing, P. F. Liu, C. H. Zhao, Y. L. Sun, E. H. Xiong*, R. H. Yang. Artifical Nucleic Acid Tractor-Directed Simultaneous Depletion of Oncogenic Membrane Proteins without Hijacking Proteolysis-Specific Actuator. CCS Chem. 2024, 6, 439–449. L. Jiang, J. L. Du, H. L. Xu, X. H. Zhuo, J. L. Ai, J. Y. Zeng, R. H. Yang, E. H. Xiong*. Ultrasensitive CRISPR/Cas13a-Mediated Photoelectrochemical Biosensors for Specific and Direct Assay of miRNA-21. Anal. Chem. 2023, 95, 1193–1200. M. Q. Huang, E. H. Xiong*, Y. Wang, M. L. Hu, H. H. Yue, T. Tian, D. B. Zhu, H. Liu, X. M. Zhou*. Fast Microwave Heating-Based One-Step Synthesis of DNA and RNA Modified Gold Nanoparticles. Nat. Commun. 2022, 13, 968. E. H. Xiong, L. Jiang, T. Tian, M. L. Hu, H. H. Yue, M. Q. Huang, W. Lin, Y. Z. Jiang, D. B. Zhu, X. M. Zhou*. Simultaneous Dual-Gene Diagnosis of SARS-CoV-2 Based on CRISPR/Cas9-Mediated Lateral Flow Assay. Angew. Chem. Int. Ed. 2021, 60, 5307–5315. (ESI Highly cited paper, Hot paper) M. L. Hu, C. Q. Yuan, T. Tian, X. S. Wang, J. Sun, E. H. Xiong*, X. M. Zhou*. Single-Step, Salt-Aging-Free, and Thiol-Free Freezing Construction of AuNP-Based Bioprobes for Advancing CRISPR-Based Diagnostics. J. Am. Chem. Soc. 2020, 142, 7506–7513. X. S. Wang, E. H. Xiong*, T. Tian, M. Cheng, W. Lin, H. Wang, G. H. Zhang, J. Sun*, X. M. Zhou* Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Mediated Lateral Flow Nucleic Acid Assay. ACS Nano 2020, 14, 2497–2508. (ESI Highly cited paper) E. H. Xiong, D. B. Yao, A. D. Ellington*, S. Bhadra*. Minimizing Leakage in Stacked Strand Exchange Amplification Circuits. ACS Synth. Biol. 2021, 10, 1277–1283. Y. J. Bao, Y. Z. Jiang, E. H. Xiong*, T. Tian, Z. Z. Zhang, J. Lv, Y. Li*, X. M. Zhou*. CUT-LAMP: Contamination-Free Loop-Mediated Isothermal Amplification Based on the CRISPR/Cas9 Cleavage. ACS Sens. 2020, 5, 1082–1091. E. H. Xiong, D. S. Zhen, L. Jiang*, X. M. Zhou*. Binding-Induced 3D-Bipedal DNA Walker for Cascade Signal Amplification Detection of Thrombin Combined with Catalytic Hairpin Assembly Strategy. Anal. Chem. 2019, 91, 15317–15324. E. H. Xiong, D. S. Zhen, L. Jiang*. Homogeneous Enzyme-Free and Entropy-Driven Isothermal Fluorescent Assay for Nucleic Acids Based on a Dual-Signal Output Amplification Strategy. Chem. Commun. 2018, 54, 12594–12597. E. H. Xiong, Z. Z. Li, X. H. Zhang*, J. W. Zhou, X. X. Yan, Y. Q. Liu, J. H. Chen*. Triple-Helix Molecular Switch Electrochemical Ratiometric Biosensor for Ultrasensitive Detection of Nucleic Acids. Anal. Chem. 2017, 89, 8830–8835. E. H. Xiong, X. H. Zhang, Y. Q. Liu, J. W. Zhou, P. Yu, X. Y. Li, J. H. Chen*. Ultrasensitive Electrochemical Detection of Nucleic Acids Based on the Dual-Signaling Electrochemical Ratiometric Method and Exonuclease III-Assisted Target Recycling Amplification Strategy. Anal. Chem. 2015, 87, 7291–7296. E. H. Xiong, X. X. Yan, X. H. Zhang*, Y. Q. Liu, J. W. Zhou, J. H. Chen*. Exonuclease III–Assisted Cascade Signal Amplification Strategy for Label-Free and Ultrasensitive Electrochemical Detection of Nucleic Acids. Biosens. Bioelectron. 2017, 87, 732–736. E. H. Xiong, L. Wu, J. W. Zhou, P. Yu, X. H. Zhang*, J. H. Chen*. A Ratiometric Electrochemical Biosensor for Sensitive Detection of Hg2+Based on Thymine-Hg2+-Thymine Structure. Anal. Chim. Acta 2015, 853, 242–248. D. B. Yao, S. Bhadra, E. H. Xiong, H. J. Liang, A. D. Ellington*, C. Jung*. Dynamic Programming of a DNA Walker Controlled by Protons. ACS Nano 2020, 14, 4007–4013. H. H. Yue, M. Q. Huang, T. Tian, E. H. Xiong, X. M. Zhou*. Advances in Clustered, Regularly Interspaced Short Palindromic Repeats (CRISPR)-Based Diagnostic Assays Assisted by Micro/Nanotechnologies. ACS Nano 2021, 15, 7848–7859.