DeSimone, Joseph M. - Stanford University - Department of Chemical Engineering

个人简介

Joseph M. DeSimone is the Sanjiv Sam Gambhir Professor of Translational Medicine and Chemical Engineering at Stanford University. He holds appointments in the Departments of Radiology and Chemical Engineering with courtesy appointments in the Department of Chemistry and in Stanford’s Graduate School of Business. The DeSimone laboratory's research efforts are focused on developing innovative, interdisciplinary solutions to complex problems centered around advanced polymer 3D fabrication methods. In Chemical Engineering and Materials Science, the lab is pursuing new capabilities in digital 3D printing, as well as the synthesis of new polymers for use in advanced additive technologies. In Translational Medicine, research is focused on exploiting 3D digital fabrication tools to engineer new vaccine platforms, enhanced drug delivery approaches, and improved medical devices for numerous conditions, with a current major focus in pediatrics. Complementing these research areas, the DeSimone group has a third focus in Entrepreneurship, Digital Transformation, and Manufacturing. Before joining Stanford in 2020, DeSimone was a professor of chemistry at the University of North Carolina at Chapel Hill and of chemical engineering at North Carolina State University. He is also Co-founder, Board Chair, and former CEO (2014 - 2019) of the additive manufacturing company, Carbon. DeSimone is responsible for numerous breakthroughs in his career in areas including green chemistry, medical devices, nanomedicine, and 3D printing. He has published over 350 scientific articles and is a named inventor on over 200 issued patents. Additionally, he has mentored 80 students through Ph.D. completion in his career, half of whom are women and members of underrepresented groups in STEM. In 2016 DeSimone was recognized by President Barack Obama with the National Medal of Technology and Innovation, the highest U.S. honor for achievement and leadership in advancing technological progress. He has received numerous other major awards in his career, including the U.S. Presidential Green Chemistry Challenge Award (1997); the American Chemical Society Award for Creative Invention (2005); the Lemelson-MIT Prize (2008); the NIH Director’s Pioneer Award (2009); the AAAS Mentor Award (2010); the Heinz Award for Technology, the Economy and Employment (2017); the Wilhelm Exner Medal (2019); the EY Entrepreneur of the Year Award (2019 U.S. Overall National Winner); and the Harvey Prize in Science and Technology (2020). He is one of only 25 individuals elected to all three branches of the U.S. National Academies (Sciences, Medicine, Engineering). DeSimone received his B.S. in Chemistry in 1986 from Ursinus College and his Ph.D. in Chemistry in 1990 from Virginia Tech.

研究领域

The DeSimone laboratory's research efforts are focused on developing innovative, interdisciplinary solutions to complex problems centered around advanced polymer 3D fabrication methods. In Chemical Engineering and Materials Science, the lab is pursuing new capabilities in digital 3D printing, as well as the synthesis of new polymers for use in advanced additive technologies. In Translational Medicine, research is focused on exploiting 3D digital fabrication tools to engineer new vaccine platforms, enhanced drug delivery approaches, and improved medical devices for numerous conditions, with a current major focus in pediatrics. Complementing these research areas, the DeSimone group has a third focus in Entrepreneurship, Digital Transformation, and Manufacturing.

近期论文

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Single-digit-micrometer-resolution continuous liquid interface production. Science advances Hsiao, K., Lee, B. J., Samuelsen, T., Lipkowitz, G., Kronenfeld, J. M., Ilyn, D., Shih, A., Dulay, M. T., Tate, L., Shaqfeh, E. S., DeSimone, J. M.2022; 8 (46): eabq2846 3D-Printed Microarray Patches for Transdermal Applications JACS AU Rajesh, N. U., Coates, I., Driskill, M. M., Dulay, M. T., Hsiao, K., Ilyin, D., Jacobson, G. B., Kwak, J., Lawrence, M., Perry, J., Shea, C. O., Tian, S., DeSimone, J. M. Injection continuous liquid interface production of 3D objects. Science advances Lipkowitz, G., Samuelsen, T., Hsiao, K., Lee, B., Dulay, M. T., Coates, I., Lin, H., Pan, W., Toth, G., Tate, L., Shaqfeh, E. S., DeSimone, J. M.2022; 8 (39): eabq3917 Characterization of a 30 m pixel size CLIP-based 3D printer and its enhancement through dynamic printing optimization. Additive manufacturing Lee, B. J., Hsiao, K., Lipkowitz, G., Samuelsen, T., Tate, L., DeSimone, J. M.2022; 55 Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity. Proceedings of the National Academy of Sciences of the United States of America Caudill, C., Perry, J. L., Iliadis, K., Tessema, A. T., Lee, B. J., Mecham, B. S., Tian, S., DeSimone, J. M.2021; 118 (39) Methods for modeling and real-time visualization of CLIP and iCLIP-based 3D printing GIANT Lipkowitz, G., Coates, I., Krishna, N., Shaqfeh, E. G., DeSimone, J. M.2024; 17 Stretchable, recyclable thermosets via photopolymerization and 3D printing of hemiacetal ester-based resins. Chemical science Wu, Y. M., Chyr, G., Park, H., Makar-Limanov, A., Shi, Y., DeSimone, J. M., Bao, Z.2023; 14 (44): 12535-12540 Stretchable, recyclable thermosets via photopolymerization and 3D printing of hemiacetal ester-based resins CHEMICAL SCIENCE Wu, Y., Chyr, G., Park, H., Makar-Limanov, A., Shi, Y., Desimone, J. M., Bao, Z.2023 Palete-PrintAR: an augmented reality fluidic design tool for multicolor resin 3D printing Lipkowitz, G., Shaqfeh, E. G., DeSimone, J. M., ACM ASSOC COMPUTING MACHINERY. 2023 Printing atom-efficiently: faster fabrication of farther unsupported overhangs by fluid dynamics simulation Lipkowitz, G., Krishna, N., Coates, I., Shaqfeh, E. G., DeSimone, J. M., Spencer, S. N. ASSOC COMPUTING MACHINERY. 2023 Review of high-performance sustainable polymers in additive manufacturing GREEN CHEMISTRY Chyr, G., DeSimone, J. M.2022 3D-Printed Microarray Patches for Transdermal Applications. JACS Au Rajesh, N. U., Coates, I., Driskill, M. M., Dulay, M. T., Hsiao, K., Ilyin, D., Jacobson, G. B., Kwak, J. W., Lawrence, M., Perry, J., Shea, C. O., Tian, S., DeSimone, J. M.2022; 2 (11): 2426-2445 INNOVATION IN MENTORSHIP ISSUES IN SCIENCE AND TECHNOLOGY Farrell, C. L., Dulay, M. T., DeSimone, J. M. 2022; 39 (1): 10-11 3D Printing Medical Devices AMERICAN SCIENTIST DeSimone, J. 2022; 110 (4): 235-237 Continuous Liquid Interface Production of 3D Printed Drug-Loaded Spacers to Improve Prostate Cancer Brachytherapy Treatment. Acta biomaterialia Hagan, C. T., Bloomquist, C., Kim, I., Knape, N. M., Byrne, J. D., Tu, L., Wagner, K., Mecham, S., DeSimone, J., Wang, A. Z.2022 3D printed drug-loaded implantable devices for intraoperative treatment of cancer. Journal of controlled release : official journal of the Controlled Release Society Tilden Hagan, C. 4., Bloomquist, C., Warner, S., Knape, N. M., Kim, I., Foley, H., Wagner, K., Mecham, S., DeSimone, J., Wang, A. Z.2022 Generative co-design for microfluidics-accelerated 3D printing Lipkowitz, G., Shaqfeh, E. G., DeSimone, J. M., Spencer, S. N.ASSOC COMPUTING MACHINERY. 2022 Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Caudill, C., Perry, J. L., Iliadis, K., Tessema, A. T., Lee, B. J., Mecham, B. S., Tian, S., DeSimone, J. M.2021; 118 (39) Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy (vol 12, pg 877, 2017) NATURE NANOTECHNOLOGY Min, Y., Roche, K. C., Tian, S., Eblan, M. J., McKinnon, K. P., Caster, J. M., Chai, S., Herring, L. E., Zhang, L., Zhang, T., DeSimone, J. M., Tepper, J. E., Vincent, B. G., Serody, J. S., Wang, A. Z.2021; 16 (6): 743-744 Impact of Frictional Interactions on Conductivity, Diffusion, and Transference Number in Ether- and Perfluoroether-Based Electrolytes JOURNAL OF THE ELECTROCHEMICAL SOCIETY Grundy, L. S., Shah, D. B., Nguyen, H. Q., Diederichsen, K. M., Celik, H., DeSimone, J. M., McCloskey, B. D., Balsara, N. P.2020; 167 (12) Role of Linker Length and Antigen Density in Nanoparticle Peptide Vaccine ACS OMEGA Kapadia, C. H., Tian, S., Perry, J. L., Luft, J., Desimone, J. M.2019; 4 (3): 5547-5555 Formulation of High-Performance Dry Powder Aerosols for Pulmonary Protein Delivery PHARMACEUTICAL RESEARCH Wilson, E. M., Luft, J., DeSimone, J. M.2018; 35 (10): 195 Use of iontophoresis for the treatment of cancer JOURNAL OF CONTROLLED RELEASE Byrne, J. D., Yeh, J., DeSimone, J. M.2018; 284: 144-151 Impact of formulation on the iontophoretic delivery of the FOLFIRINOX regimen for the treatment of pancreatic cancer CANCER CHEMOTHERAPY AND PHARMACOLOGY Byrne, J. D., Jajja, M. N., O'Neill, A. T., Schorzman, A. N., Keeler, A. W., Luft, J., Zamboni, W. C., DeSimone, J. M., Yeh, J.2018; 81 (6): 991-998 Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins JOURNAL OF CONTROLLED RELEASE Bloomquist, C. J., Mecham, M. B., Paradzinsky, M. D., Janusziewicz, R., Warner, S. B., Luft, J., Mecham, S. J., Wang, A. Z., DeSimone, J. M.2018; 278: 9-23 Extending antigen release from particulate vaccines results in enhanced antitumor immune response JOURNAL OF CONTROLLED RELEASE Kapadia, C. H., Tian, S., Perry, J. L., Sailer, D., Luft, J., DeSimone, J. M.2018; 269: 393-404 Crosslinked perfluoropolyether solid electrolytes for lithium ion transport SOLID STATE IONICS Devaux, D., Villaluenga, I., Bhatt, M., Shah, D., Chen, X., Thelen, J. L., DeSimone, J. M., Balsara, N. P.2017; 310: 71-80 Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy NATURE NANOTECHNOLOGY Min, Y., Roche, K. C., Tian, S., Eblan, M. J., McKinnon, K. P., Caster, J. M., Chai, S., Herring, L. E., Zhang, L., Zhang, T., DeSimone, J. M., Tepper, J. E., Vincent, B. G., Serody, J. S., Wang, A. Z. 2017; 12 (9): 8 7-+ Mechanism of ion transport in perfluoropolyether electrolytes with a lithium salt SOFT MATTER Timachova, K., Chintapalli, M., Olson, K. R., Mecham, S. J., DeSimone, J. M., Balsara, N. P.2017; 13 (32): 5389-5396