苏一驰 - 复旦大学 - 脑科学转化研究院

个人简介

苏一驰，脑科学转化研究院青年研究员，博士生导师，入选国家级、上海市青年高层次人才计划。2013年本科毕业于北京大学化学学院，获得化学生物学学士学位；随后在美国加州大学伯克利分校师从Dr. Ming C. Hammond导师，于2018年取得化学博士学位；随后在斯坦福大学Dr. Michael Z. Lin领导的实验室进行博士后研究。主要研究成果发表在Nature Methods, Nature Chemical Biology, ACS Central Science, Journal of the American Chemical Society等高影响力学术杂志上。自2023年10月起，加入复旦大学脑科学转化研究院，专注于蛋白分子工具的研发，旨在开发高效、精准且无创的光学成像技术，以推动脑疾病研究和治疗手段的创新。

研究领域

分子光学成像具备在复杂微观环境中实时监测错综复杂的分子网络和生化过程的能力，在近年来对推动生物科学研究中的重要性逐渐凸显。针对充满挑战的脑科学研究，尤其是理解健康大脑的运作机制和脑疾病的病因形成，分子成像技术同样具有不可或缺的价值。为了在脑科学领域取得突破，加深对神经系统疾病的认知，并推动有效治疗技术的研发，我们的课题组专注于推进分子光学成像方法在脑疾病研究中的应用。我们综合运用化学生物学、蛋白质工程、合成生物学、小动物体内成像以及蛋白质计算设计等多种前沿研究手段，致力于开发创新的蛋白分子成像工具。我们的研究方向主要集中于以下几个方面：创立通用的生物发光指示蛋白的设计策略研发新型生物发光分子体系，推进脑研究的多重光学成像利用光指示蛋白实时评估药物在动物大脑中的效用基于光指示蛋白监测神经退行性疾病中的异常蛋白质行为

近期论文

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Before Joining ITBR Westberg, M.#, Su, Y., Zou, X., Huang, P., Rustagi, A., Garhyan, J., Patel, P. B., Fernandez, D., Wu, Y., Hao, C., Lo, C-W., Karim, M., Ning, L., Beck, A., Saenkham-Huntsinger, P., Tat, V., Drelich, A., Peng, B., Einav, S., Tseng, C. K., Blish, C., Lin, M. Z.#, “An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations” Sci. Transl. Med. (2024) 16, eadi0979 Wu, Y.*, Walker, J. R., Ning, L., Westberg, M., Monje, M., Kirkland, T. A., Lin, M. Z.#, Su, Y.*#, “Kinase-modulated bioluminescent indicators enable noninvasive imaging of drug activity in the brain” ACS Cent. Sci. (2023) 9(4), 719-732 Related Highlights: ACS Central Science FIRST REACTIONS; SCOPE, Stanford Medicine blog; Promega connections. Su, Y.*, Walker, J. R.*, Hall, M. P., Klein, M. A., Wu, X., Encell, L. P., Casey, K. M., Liu, L. X., Hong, G., Lin, M. Z. and Kirkland, T. A., “An optimized bioluminescent substrate for non-invasive imaging in the brain.” Nat. Chem. Biol., (2023) 19, 731-739. Related Highlights: Promega connections; Promega News and Press Releases. Liu, S., Su, Y., Lin, M. Z., Ronald, J. A., “Brightening up biology: advances in luciferases systems for in vivo imaging” ACS Chem. Biol., (2021) 16, 2707-2718. Su, Y.*, Walker, J. R.*, Park, Y., Smith, T. P., Liu, L. X., Hall, M. P., Labanieh, L., Hurst, R., Wang, D. C., Encell, L. P., Kim, N., Zhang, F., Kay, M. A., Casey, M. K., Majzner, R. G., Cochran. J. R., Mackall, C. L., Kirkland, T. A., Lin, M. Z., “Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals”, Nat. Methods, (2020) 17, 852-860. Related Highlights: Promega connections. Li, Y., Fin, A., Rovira, A. R., Su, Y., Dippel, A. B., Valderrama, J. A., Riestra, A. M., Nizet, V., Hammond, M. C., Tor, Y., “Tuning the innate immune response to cyclic dinucleotides using atomic mutagenesis”, ChemBioChem, (2020), 21, 2595-2598. Su, Y., Hammond, M. C., “RNA-based fluorescent biosensors for live cell imaging of small molecules and RNAs”, Curr. Opin. Biotech., (2020) 63, 157-166. Villa, J. K.*, Su, Y.*, Contreras, L. M.#, Hammond, M. C.#, “Synthetic biology of small RNAs and Riboswitches” Microbiol Spectr., (2018) 6, 3 Hallberg, Z. F., Su, Y., Kitto, Z. R., Hammond, M. C., “Engineering and in vivo applications of riboswithes” Annu. Rev. Biochem., (2017) 86, 515-539. Bose, D.*, Su, Y.*, Marcus, A., Raulet, D. H., Hammond, M. C., “An RNA-based fluorescent biosensor for high-throughput analysis of cGAS-cGAMP-STING pathway” Cell. Chem. Biol., (2016) 23, 1539-1549. Su, Y., Hickey, S. F., Keyser, S. G. L., Hammond, M. C., “In vitro and in vivo enzyme activity screening via RNA-based fluorescent biosensors for S-adenosyl-L-homocysteine (SAH)” J. Am. Chem. Soc. (2016) 138, 7040-7047. Kellenberger, C. A.*, Wilson, S. C.*, Hickey, S. F., Gonzalez, T. L., Su, Y., Hallberg, Z. F., Brewer, T. F., Iavarone, A. T., Carlson, H. K., Hsieh, Y. F., Hammond, M. C. "GEMM-I riboswitches from Geobacter sense the bacterial second messenger c-AMP-GMP" Proc. Natl. Acad. Sci., (2015) 112, 5383-5388.