舒友生 - 复旦大学 - 脑科学转化研究院

个人简介

舒友生，1994年毕业于湖南师范大学生物教育专业；1999年获中国科学院上海脑研究所神经生物学博士学位，师从痛觉研究领域巨擘赵志奇教授。1999-2006年，美国耶鲁大学麻醉学系和神经生物学系（先后在Robert H. LaMotte 和David A. McCormick教授实验室）博士后、Research Scientist。2006-2013年，中国科学院神经科学研究所建立神经网络功能课题组，研究员。2013-2019年，北京师范大学脑与认知科学研究院、认知神经科学与学习国家重点实验室，教授。2020年入职复旦大学脑科学转化研究院。获国家杰出青年基金、基金委重点项目、上海市浦江人才计划等项目的资助。获中科院青年科学家奖、优秀研究生指导教师奖等。致力于从神经元兴奋性和神经环路电活动的角度探讨脑功能机制和脑疾病发病机理，探索针对不同脑疾病的神经调控治疗策略。原创性研究工作发表在Nature、Nature Neuroscience、Neuron、PNAS、PLoS Biology、Cell Reports等学术期刊上。

研究领域

课题组主要利用电生理、离子成像、形态学、光/化学遗传学和病毒示踪等技术方法，研究神经元和神经网络电活动的形成机理和编码机制；探讨脑内各类型神经元的局部环路和跨脑区环路的突触连接特点及其在脑功能实现中的重要生理作用、在脑疾病发生发展过程中的病理作用；鉴定可调控神经元兴奋性和环路功能的重要分子；发展化学或物理的神经调控新技术。

近期论文

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Deng S, Li J, He Q, Zhang X, Zhu J, Li L, Mi Z, Yang X, Jiang M, Dong Q, Mao Y, Shu Y*. (2020) Regulation of recurrent inhibition by asynchronous glutamate release in neocortex. Neuron. pii: S0896-6273(19)30933-X. doi: 10.1016/j.neuron.2019.10.038. *** Yang J, Xiao Y, Li L, He Q, Li M and Shu Y*. (2019) Biophysical properties of somatic and axonal voltage-gated sodium channels in midbrain dopaminergic neurons. Frontiers in Cellular Neuroscience. 13:317. doi: 10.3389/fncel.2019.00317. Yin L#, Zheng R#, Ke W#, He Q#, Zhang Y, Li J, Wang B, Mi Z, Long YS, Rasch MJ, Li T, Luan G, Shu Y*. (2018) Autapses enhance bursting and coincidence detection in neocortical pyramidal cells. Nature Communications. 9(1):4890. doi: 10.1038/s41467-018-0 Yin L, Rasch M, He Q, Wu S, Dou F and Shu Y*. (2017) Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cerebral Cortex. 27(1):509-521. *** Wang B, Yin L, Zou X, Ye M, Liu Y, He T, Deng S, Jiang Y, Zheng R, Wang Y, Yang M, Lu H, Wu S and Shu Y*. (2015) A Subtype of Inhibitory Interneuron with Intrinsic Persistent Activity in Human and Monkey Neocortex. Cell Reports, Doi.org/10.1016/j.celre Jiang M, Yang M, Yin L, Zhang X, and Shu Y*. (2015) Developmental reduction of asynchronous GABA release from neocortical fast-spiking neurons, Cerebral Cortex. 25(1):258-70. *** Tian C, Wang K, Ke W, Guo H, Shu Y*. (2014) Molecular identity of axonal sodium channels in human cortical pyramidal cells. Frontiers in Cellular Neuroscience. DOI:10.3389/fncel.2014.00297 Li T, Tian C, Scalmani P, Frassoni C, Mantegazza M, Wang Y, Yang M, Wu S, Shu Y*. (2014) Action potential initiation in neocortical inhibitory interneurons. PLoS Biology. 12(9):e1001944. *** Yang J, Ye M, Tian C, Yang M, Wang Y, and Shu Y*. (2013) Dopaminergic Modulation of Axonal Potassium Channel and Action Potential Waveform in Pyramidal Neurons of Prefrontal Cortex. Journal of Physiology. 591: 3233-3251. *** Jiang M, Zhu J, Liu Y, Yang M, Tian C, Jiang S, Wang Y, Guo H, Wang K and Shu Y*. (2012) Enhancement of Asynchronous Release from Fast-Spiking Interneuron in Human and Rat Epileptic Neocortex. PLoS Biology. 10: e1001324. *** Zhu J, Jiang M, Yang M, Hou H and Shu Y*. (2011) Membrane potential-dependent modulation of recurrent inhibition in rat neocortex. PLoS Biology. 9(3): e1001032. (synopsis: Finding Balance in Cortical Networks.) *** Hu W, Tian C, Li T, Yang M, Hou H, Shu Y*. (2009) Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation. Nature Neuroscience. 12: 996-1002. (News and Views: Who let the spikes out?). *** Shu Y, Yu YG, Yang J and McCormick DA*. (2007b) Selective control of cortical axonal spikes by a slowly inactivating K+ current. PNAS. 104(27):11453-8. *** Shu Y, Duque A, Yu Y, Haider B and McCormick DA*. (2007a) Properties of action potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of Neurophysiology. 97(1):746-760. McCormick DA*, Shu Y and Yu Y. (2007) Neurophysiology: Hodgkin and Huxley model--still standing? Nature. 445(7123):E1-E2. Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA* (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature. 441: 761-765. Coments by Eve Marder: Extending influence. Nature. 441: 702-703. *** Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick DA* (2005) Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks. Neuron. 47(3): 423-435. *** Shu Y, Hasenstaub A, McCormick DA* (2003) Turning on and off recurrent balanced cortical activity. Nature. 423: 288-293. *** Shu Y, Hasenstaub A, Badoual M, Bal T and McCormick DA* (2003) Barrages of synaptic activity control the gain and sensitivity of cortical neurons. Journal of Neuroscience. 23: 10388-10401 Shu Y and McCormick DA* (2002) Inhibitory interactions between ferret thalamic reticular neurons. Journal of Neurophysiology. 87(5): 2571-2576.