个人简介
谭超,脑科学转化研究院青年研究员,附属中山医院双聘研究员,博士生导师。2018年6月博士毕业于浙江大学药学院药理学专业,2018年10月至2023年5月于哈佛大学医学院神经生物系从事博士后研究,主要研究成果以第一作者/共同第一作者发表在Neuron (2篇)、eLife、Cerebral Cortex和Stem Cell Reports等国际学术期刊。2023年6月加入复旦大学,主要从事突触传递与突触形成,以及神经退行性疾病调控方面的研究。入选上海市高层次人才计划。
研究领域
突触形成和突触传递是大脑信息处理和脑功能实现的基础。研究突触形成和突触传递有助于理解脑功能的神经机制,并解析神经退行性疾病的病理机制。课题组结合分子生物学、原代神经元培养、电生理、超分辨显微成像、电镜成像、光纤记录和行为学分析等技术,探究突触形成和突触传递的分子机制,解析其在神经退行性疾病进程中的病理改变,为相关疾病的改善和治疗开发新的分子工具。
近期论文
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Chao Tan, Shan Shan H. Wang, Giovanni de Nola, Pascal S. Kaeser. Rebuilding essential active zone functions within a synapse, Neuron, 2022, 110(9): 1498-1515.
Chao Tan, Giovanni de Nola, Claire Qiao, Cordelia Imig, Richard T. Born, Nils Brose, Pascal S. Kaeser. Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones, eLife, 2022, 11: e79077.
Chao Tan*, Nan-Nan Lu*, Cheng-Kun Wang, Dan-Yang Chen, Ning-He Sun, Hang Lyu, Jakob Körbelin, Wei-Xing Shi, Kohji Fukunaga, Ying-Mei Lu, Feng Han. Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4, Neuron, 2019, 101(5): 920-937.
Nan-Nan Lu*, Chao Tan*, Ning-He Sun, Ling-Xiao Shao, Xiu-Xiu Liu, Yin-Ping Gao, Rong-Rong Tao, Quan Jiang, Cheng-Kun Wang, Ji-Yun Huang, Kui Zhao, Guang-Fa Wang, Zhi-Rong Liu, Kohji Fukunaga, Ying-Mei Lu, Feng Han. Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function, Cerebral Cortex, 2018, 28(7): 2391-2404.
Shishi Li*, Huaye Pan*, Chao Tan*, Yaping Sun, Yanrui Song, Xuan Zhang, Wei Yang, Xuexiang Wang, Dan Li; Yu Dai, Qiang Ma, Chenming Xu, Xufen Zhu, Lijun Kang, Yong Fu, Xuejun Xu, Jing Shu, Naiming Zhou, Feng Han, Dajiang Qin, Wendong Huang, Zhong Liu, Qingfeng Yan. Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation, Stem Cell Reports, 2018, 10(3): 808-821.
Xing-Guang Liang, Chao Tan, Cheng-Kun Wang, Rong-Rong Tao, Yu-Jie Huang, Kui-Fen Ma, Kohji Fukunaga, Ming-Zhu Huang, Feng Han. Myt1l induced direct reprogramming of pericytes into cholinergic neurons, CNS Neuroscience & Therapeutics, 2018, 24(9): 801-809.