邵志成 - 复旦大学 - 脑科学转化研究院

个人简介

邵志成，博士毕业于上海交通大学,先后在中国科学院神经科学研究所,阿拉巴马大学以及哈佛大学进行博士后研究。2020年2月加入复旦大学脑科学转化研究院，博士生导师，上海市东方学者特聘教授，主要从事体细胞重编程，中枢神经系统再生，以及精神疾病发病机制研究。课题组利用特定疾病类型的诱导多能干细胞，结合3D类脑器官(Organoid)等技术，研究精神疾病的发生发展机制，寻找药物靶点和建立药物筛选平台。同时利用转分化技术，结合材料科学制备类器官芯片，探究3D-organoid移植治疗中枢神经系统组织再生的新策略。目前，以第一作者和通讯作者在国内外重要学术刊物上发表多篇论文，其中包括Nature Biomedical Engineering, Nature Neuroscience, Biomaterials, Nature Communications, Cell Reports等。

研究领域

体细胞重编程技术和机制研究精神分裂症发病机制研究 3D-organoid与中枢神经再生

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Weiwei Xue#*, Bo Li#, Huihui Liu#, Yujie Xiao, Bo Li, Lei Ren, Huijuan Li, Zhicheng Shao*. Generation of Dorsoventral Human Spinal Cord Organoids via Functionalizing Composite Scaffold for Drug Testing. iScience, 2023, 26, 105898 Xu J.#; Fang S; Wang N.; Li B; Huang Y.; Fan Q; Shi J.; Liu H.; Shao Z.*, Dual?specifcity Tyrosine Phosphorylation?regulated Kinase Inhibitor ID?8 Promotes Human Somatic Cell Reprogramming by Activating PDK4 Expression. Stem Cell Reviews and Reports (2022) 18:2074–2087 Xu J.#; Fang S#; Deng S.; Li H.; Lin X.; Huang Y.; Chung S.; Shu Y.; Shao Z.*, Generation of neural organoids for spinal-cord regeneration via the direct reprogramming of human astrocytes. Nature Biomedical Engineering 2022, doi.org/10.1038/s41551-022-00963-6 (online) Shao Z, Cevallos RR, and Hu K，Reprogramming Human Fibroblasts to Induced Pluripotent Stem Cells Using the GFP-Marked Lentiviral Vectors in the Chemically Defined Medium. (from Book,Kejin Hu (ed.), Nuclear Reprogramming: Methods and Protocols, Methods in Molecular Biology, vol. 2239, Chapter 7，? Springer Science+Business Media, LLC, part of Springer Nature 2021) Park G.; Noh H.; Shao Z.; Ni P.; QinY.; Liu D.; Beaudreault C.; Park J.; Abani C.; ParkJ.; Le D.; Gonzalez S.; Guan Y.; Cohen B.; McPhie D.; Coyle J.; Lanz T.; Xi H.; Yin C.; Huang W.; Kim H.; Chung S., Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia. Nature neuroscience 2020, 23, 1352-1364. Zhao, J#.; Ye, Z#.; Yang, J#.; Zhang, Q.; Shan, W.; Wang, X.; Wang, Z.; Ye, S.; Zhou, X.; Shao, Z*.; Ren, L*., Nanocage encapsulation improves antiepileptic efficiency of phenytoin. Biomaterials 2020, 240, 119849. Zeng, F#.; Ma, X#.; Zhu, L.; Xu, Q.; Zeng, Y.; Gao, Y.; Li, G.; Guo, T.; Zhang, H.; Tang, X.; Wang, Z.; Ye, Z.; Zheng, L.; Zhang, H.; Zheng, Q.; Li, K.; Lu, J.; Qi, X.; Luo, H.; Zhang, X.; Wang, Z.; Zhou, Y.; Yao, Y.; Ke, R.; Zhou, Y.; Liu, Y.; Sun, H.; Huang, T.; Shao, Z.; Xu, H.; Wang, X*., The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. PLoS Biol 2019, 17 (12), e3000525. Shao, Z#.; Noh, H#.; Bin Kim, W.; Ni, P.; Nguyen, C.; Cote, S. E.; Noyes, E.; Zhao, J.; Parsons, T.; Park, J. M.; Zheng, K.; Park, J. J.; Coyle, J. T.; Weinberger, D. R.; Straub, R. E.; Berman, K. F.; Apud, J.; Ongur, D.; Cohen, B. M.; McPhie, D. L.; Rapoport, J. L.; Perlis, R. H.; Lanz, T. A.; Xi, H. S.; Yin, C.; Huang, W.; Hirayama, T.; Fukuda, E.; Yagi, T.; Ghosh, S.; Eggan, K. C.; Kim, H. Y.; Eisenberg, L. M.; Moghadam, A. A.; Stanton, P. K.; Cho, J. H*.; Chung, S*., Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia. Nat Neurosci 2019, 22 (2), 229-242. Ni, P.; Noh, H.; Shao, Z.; Zhu, Q.; Guan, Y.; Park, J. J.; Arif, F.; Park, J. M.; Abani, C.; Beaudreault, C.; Park, J. S.; Berry, E.; Moghadam, A.; Stanton, P.; Hutchinson, J. N.; Andrews, B.; Faux, C.; Parnevelas, J.; Eisenberg, L. M.; Park, K.; Bolshakov, V. Y.; Chung, S*., Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells. Mol Ther Methods Clin Dev 2019, 13, 414-430. Ni, P#.; Noh, H#.; Park, G. H.; Shao, Z.; Guan, Y.; Park, J. M.; Yu, S.; Park, J. S.; Coyle, J. T.; Weinberger, D. R.; Straub, R. E.; Cohen, B. M.; McPhie, D. L.; Yin, C.; Huang, W.; Kim, H. Y.; Chung, S*., iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function. Mol Psychiatry 2019. Leng, L#.; Zhuang, K#.; Liu, Z.; Huang, C.; Gao, Y.; Chen, G.; Lin, H.; Hu, Y.; Wu, D.; Shi, M.; Xie, W.; Sun, H.; Shao, Z.; Li, H.; Zhang, K.; Mo, W.; Huang, T. Y.; Xue, M.; Yuan, Z.; Zhang, X.; Bu, G.; Xu, H.; Xu, Q*.; Zhang, J*., Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation. Neuron 2018, 100 (3), 551-563 e7. Noh, H#.; Shao, Z#.; Coyle, J. T.; Chung, S*., Modeling schizophrenia pathogenesis using patient-derived induced pluripotent stem cells (iPSCs). Biochim Biophys Acta Mol Basis Dis 2017, 1863 (9), 2382-2387. Shao, Z.; Zhang, R.; Khodadadi-Jamayran, A.; Chen, B.; Crowley, M. R.; Festok, M. A.; Crossman, D. K.; Townes, T. M.; Hu, K*., The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis. Nat Commun 2016, 7, 10869. Shao, Z#.; Yao, C#.; Khodadadi-Jamayran, A#.; Xu, W.; Townes, T. M.; Crowley, M. R.; Hu, K*., Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET Bromodomains. Cell Rep 2016, 16 (12), 3138-3145. Shao, Z.; Luo, Q.; Liu, D.; Mi, Y.; Zhang, P.; Ju, G*., Induced differentiation of neural stem cells of astrocytic origin to motor neurons in the rat. Stem Cells Dev 2011, 20 (7), 1163-70.