李世斌 - 复旦大学 - 脑科学转化研究院

个人简介

李世斌，复旦大学脑科学转化研究院青年研究员，复旦大学附属中山医院双聘专家，博士生导师，入选国家级、上海市青年高层次人才计划。博士毕业于德国海德堡大学/马普医学研究所，之后加入斯坦福大学医学院Luis de Lecea教授实验室，先后任博士后、研究科学家、讲师。2022年9月加入复旦大学脑科学转化研究院，主要研究方向为衰老、压力相关睡眠障碍的发生机制和治疗策略，及神经免疫调节。研究成果以第一或通讯作者发表在Science、Science Advances、Sleep、Cerebral Cortex、Neuroscience等学术期刊，以第一作者或通讯作者在Clinical and Translational Medicine、Neuropharmacology、Current Psychiatry Reports、Current Topics in Behavioral Neurosciences、Frontiers in Neuroscience发表综述/社论，以共同作者在Nature Neuroscience、Nature Communications、Cell Reports、Communications Biology等学术期刊发表文章。荣获美国睡眠研究学会颁发的杰出青年研究员奖(Sleep Research Society Outstanding Early Investigator Award) , 获美国睡眠研究学会基金会职业发展奖(Sleep Research Society Foundation Career Development Award), 大脑与行为研究基金会NARSAD青年研究员奖(Brain and Behavior Research Foundation/BBRF NARSAD Young Investigator)；任Frontiers in Neuroscience客座编辑，为Nature Neuroscience、Nature Metabolism、Cell Reports、Sleep、Neuropharmacology、Behavioral Brain Research等学术期刊特邀审稿专家。

研究领域

课题组主要使用小鼠模型结合脑电图/肌电图记录、电生理、免疫组化、在体钙成像、光遗传学、化学遗传学、CRISPR/Cas基因编辑、snRNA-Seq等实验技术研究睡眠调控和睡眠障碍的产生机制和干预策略，及神经免疫调节。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Tyree, S.M., Jennings, K.J., Gonzalez, O.C., Li, S.B., Nicholson, J.R., von Heimendahl, M., and de Lecea, L. (2023). Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice. Commun Biol 6, 74. Pi?ol-Ripoll G, Lima M.M.S., Li, S.B.*, Targa A.D.S.* (2023) Editorial: The underlying relationship between sleep and neurodegenerative diseases. Front. Neurosci. 16:1117265, pp1-3, *Co-corresponding. Li, S.B.*, de Lecea L. (2022) The brake matters: Hyperexcitable arousal circuits in sleep fragmentation with age. Clin Transl Med 12 6, pp 1-4, *Corresponding author Li S.B?., Damonte V.M.?, Chen C., Wang G.X., Kebschull J., Yamaguchi H., Bian W.J., Purmann C., Pattni R., Urban A.E., Mourrain P., Kauer J.A., Scherrer G., de Lecea L. (2022) Hyperexcitable arousal circuits drive sleep instability during aging. Science 375 838, eabh3021, pp 1-14, ?equal contribution, Owens-French J., Li S.B., Francois M., Townsend R.L., Daniel M., Soulier H., Turner A., de Lecea L., Münzberg H., Morrison C., & Qualls-Creekmore E. (2022) Lateral hypothalamic galanin neurons are activated by stress and blunt anxiety-like behavior in mice. Behavioral Brain Research 423, 113773, pp 1-10 Bertocchi I., Eltokhi A., Rozov A., Chi V.N., Jensen V., Bus T., Pawlak V., Serafino M., Sonntag H., Yang B., Burnashev N., Li S.B., Obenhaus H.A., Both M., Niewoehner B., Single F.N., Briese M., Boerner T., Gass P., Rawlins J.N.P., K?hr G., Bannerman D.M., and Sprengel R. (2021) Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. Communications Biology 4:59, pp 1-21 Li S.B.*, Borniger J.C., Yamaguchi H., Hédou J., Gaudilliere B., de Lecea L.* (2020) Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression. Science Advances, 6:eabc2590, pp 1-13, *Co-corresponding. Li S.B.*, Borniger J.C., Yamaguchi H., Hédou J., Gaudilliere B., de Lecea L.* (2020) Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression. bioRxiv, pp 1-28, *Co-corresponding Li P., Li S.B., Wang X., Phillips C.D., Schwarz L.A., Luo L., de Lecea L., and Krasnow M.A. (2020) Brain circuit of claustrophobia-like behavior in mice identified by upstream tracing of sighing. Cell reports 31, 107779, pp 1-11 Li S.B.*, and de Lecea L.*. (2020) The hypocretin (orexin) system: from a neural circuitry perspective. Neuropharmacology 167, 107993, pp 1-14, *Co-corresponding Yamaguchi H., Hopf W., Li S.B., and de Lecea L. (2018) In vivo cell type-specific CRISPR knockdown of dopamine beta-hydroxylase reduces locus coeruleus evoked wakefulness. Nature Communications 9:5211, pp 1-8. Giardino W.J., Eban-Rothschild A., Christoffel D.J., Li S.B., Malenka R.C., and de Lecea L. (2018) Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nature Neuroscience 21, pp 1084-1095 Li, S.B., Névarez, N., Giardino, W.J., and de Lecea, L. (2018) Optical Probing of Orexin/Hypocretin Receptor Antagonists. Sleep, 41:10, pp 1-13, Selected as EDITOR’S CHOICE Li S.B., Giardino W.J., de Lecea L. (2017) Hypocretins and arousal. Current Topics in Behavioral Neurosciences, pp 93-104. Castellano J.M., Palner M., Li S.B., Freeman G.M. Jr, Nguyen A., Shen B., Stan T., Mosher K.I., Chin F.T., de Lecea L., Luo J., Wyss-Coray T. (2016) In vivo assessment of behavioral recovery and circulatory factor exchange in the peritoneal parabiosis model. Scientific Reports, 6:29015, pp 1-9 Li S.B., Jones J.R., de Lecea L. (2016) Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders. Current Psychiatry Reports, 18:7, pp 1-12. Li S.B., Du D., Hasan M.T., K?hr G. (2016) D4 Receptor Activation Differentially Modulates Hippocampal Basal and Apical Dendritic Synapses in Freely Moving Mice. Cerebral Cortex 26, pp 647-655 Trevino M., Oviedo T., Jendritza P., Li S.B., K?hr G. & De Marco R.J. (2013) Controlled variations in stimulus similarity during learning determine visual discrimination capacity in freely moving mice. Scientific Reports 3:1048, pp 1-13 Trevino M., Aguilar-Garnica E., Jendritza P., Li S.B., Oviedo T., K?hr G. & De Marco R.J. (2011) Discrimination learning with variable stimulus 'salience'. International archives of medicine 4:26, pp 1-4. Li S.B., He Z., Guo L., Huang L., Wang J. & He W. (2010) Behavioral alterations associated with a down regulation of HCN1 mRNA in hippocampal cornus ammon 1 region and neocortex after chronic incomplete global cerebral ischemia in rats. Neuroscience 165, pp 654-661