李博 - 复旦大学 - 脑科学转化研究院

个人简介

李博，复旦大学脑科学转化研究院研究员，博士生导师，国家优青，上海市求索杰出青年、青年东方学者、海外高层次引进人才。李博2009年在山东大学获得应用物理学士学位，2011年和2015年在北京交通大学获得通信硕士和博士学位，2012-2014在加拿大INRS-EMT从事超快光电信号处理研究，2015-2020年在美国康奈尔大学从事激光和多光子显微镜领域的博士后研究，2020年10月加入复旦大学脑转化研究院。李博的主要科研方向是三光子、双光子和光片显微镜的技术研发，以及它们在大脑神经环路结构和功能上的应用研究。曾获得美国光学学会和相干公司颁发的项2020 Bernard J. Couillaud Prize，在Nature Methods等国际权威期刊发表论文28篇，在国际学术会议作受邀或主题报告10余次和网上公开课2次。目前是学术期刊Frontiers in Neuroscience、Photonics的客座编辑。

研究领域

新技术和新工具的研发是脑科学研究的重要方向，例如美国脑计划“BRAIN”的全称为“推进创新神经科学技术脑研究计划”（The Brain Research Through Advancing Innovative Neurotechnologies）。本课题组聚焦研发活体动物大脑神经元功能记录与刺激（三光子、双光子和相干拉曼显微成像，双光子光遗传学刺激）和透明化全脑结构成像（光片显微成像）。课题组拥有物理、工程和神经生物学方向的专家，开展多学科协同作战的技术和应用课题。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Yu-Xuan Ren, Johannes Frueh, Zhisen Zhang, Sven Rutkowski, Yi Zhou, Huade Mao, Cihang Kong, Sergei I. Tverdokhlebov, Wen Liu, Kenneth K. Y. Wong, and Bo Li, "Topologically protected optical pulling force on synthetic particles through photonic nanojet," Nanophotonics, vol. 13, no. 2, 2024, pp. 239-249. https://doi.org/10.1515/nanoph-2023-0740 Yujie Xiao, Peng Deng, Yaoguang Zhao, Shasha Yang, and Bo Li, "Three-photon excited fluorescence imaging in neuroscience: From principles to applications," Frontiers in Neuroscience, 2023, 17:1085682. https://doi.org/10.3389/fnins.2023.1085682 Bo Li, Lingjie Kong, Kiryl Piatkevich and Hod Dana, "Editorial: Large-scale Recording of Neuronal Activity at High Spatiotemporal Resolutions and Applications in Neuroscience," Frontiers in Neuroscience, 2023, 17:1202207. https://doi.org/10.3389/fnins.2023.1202207 Weiwei Xue, Bo Li, Huihui Liu, Yujie Xiao, Bo Li, Lei Ren, Huijuan Li, Zhicheng Sha, "Generation of Dorsoventral Human Spinal Cord Organoids via Functionalizing Composite Scaffold for Drug Testing," iScience, 2022, 4, 39-43.https://doi.org/10.1016/j.isci.2022.105898 Yujie Xiao, Biqing Xue, Shasha Yang and Bo Li, "多光子成像技术：解析大脑深部的利剑," 科学, 2022, 4, 39-43. https://mall.cnki.net/magazine/magadetail/KXZZ202204.htm Nan Zhang, Ruihong Dai, Weiqi Jiang, Yafei Meng, Bo Li and Fengqiu Wang, "950 nm Femtosecond Laser by Directly Frequency-doubling of a Thulium-doped Fiber Laser," IEEE Photonics Technology Letters, 2022, 34(9), 498-501. https://ieeexplore.ieee.org/document/9759336.DOI: 10.1109/LPT.2022.3168297. Huiyun Yu, Leiyun Yang, Zhan Li, Feng Sun, Bo Li, Shengsong Guo, Yong-Fei Wang, Tong Zhou, Jian Hua, "In situ deletions reveal regulatory components for expression of an intracellular immune receptor gene and its co‐expressed genes in Arabidopsis," Plant, Cell & Environment, 2022, 45(6), 1862-1875. https://doi.org/10.1111/pce.14293 Fei Xia, Monique Gevers, Andreas Fognini, Aaron T. Mok, Bo Li, Najva Akbari, Iman Esmaeil Zadeh, Jessie Qin-Dregely, and Chris Xu, "Short-Wave Infrared Confocal Fluorescence Imaging of Deep Mouse Brain with a Superconducting Nanowire Single-Photon Detector," ACS Photonics, 2021, 8(9), 2800-2810. https://doi.org/10.1021/acsphotonics.1c01018 B. Li, C. Wu, M. Wang, K. Charan, and C. Xu, "An adaptive excitation source for high speed multiphoton microscopy," Nature Methods, Vol. 17, pp. 163-166, 2020. J. Yan, H. Yu, B. Li, A. Fan, J. Melkonian, X. Wang, T. Zhou, J. Hua, "Cell autonomous and non-autonomous functions of plant intracellular immune receptors in stomatal defense and apoplastic defense," PLoS pathogens, Vol. 15, pp. 1-25, 2019. Y. Qin, B. Li, F. Xia, Y. Xia and C. Xu, "Multi-color background-free coherent anti-Stokes Raman scattering microscopy using a time-lens source," Opt. Express, vol. 26, pp. 34474-34483 2018. F. Xia, C. Wu, D. Sinefeld, B. Li, Y. Qin and C. Xu, "In vivo label-free confocal imaging of the deep mouse brain with long-wavelength illumination," Bio. Opt. Express, vol. 9, pp. 6545-6555 2018. M. Wang, C. Wu, D. Sinefeld, B. Li, F. Xia and C. Xu, "Comparing the effective attenuation lengths for long wavelength in vivo imaging of the mouse brain," Bio. Opt. Express, vol. 9, pp. 3534-3543 2018. B. Li, M. Wang, K. Charan, and C. Xu, "Investigation of the long wavelength limit of soliton self-frequency shift in a silica fiber," Opt. Express, vol. 26, pp. 19637-19647 2018. K. Charan, B. Li, M. Wang, C. P. Lin and C. Xu, "Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy," Bio. Opt. Express, vol. 9, pp. 2304-2311 2018. M. Li, S. Sun, B. Li, H. Asghari, Y. Deng, W. Li and N. Zhu, "Time-bandwidth compression of microwave signals," Opt. Express, vol. 26, pp. 990-999 2018. F. Xia, D. Sinefeld, B. Li and C. Xu, Two-photon Shack–Hartmann wavefront sensor," Opt. Lett., vol. 42, pp. 1141-1144 2017. B. Li, K. Charan, K. Wang, T. Rojo, D. Sinefeld, and C. Xu, "Nonresonant background suppression for coherent anti-Stokes Raman scattering microscopy using a multi-wavelength time-lens source," Opt. Express, vol. 24, pp. 26687-26695, 2016. B. Li and J. Aza?a, "Theory of Incoherent-Light Temporal Imaging Systems Based on a Temporal Pinhole," J. Lightwave Tech., vol. 34, pp. 2758-2773, 2016. B. Li, S. Lou, and J. Aza?a, "High-contrast linear optical pulse compression using a temporal hologram," Opt. Express, vol. 23, pp. 6833-6845, 2015. B. Li and J. Aza?a, "Temporal Imaging of Incoherent-Light Intensity Waveforms Based on a Gated Time-Lens System," Photonics J., IEEE, vol. 7, pp. 1-8, 2015. B. Li, S. Lou, and J. Aza?a, "Incoherent-light temporal imaging based on a temporal pinspeck," IEEE Photon. Tech. Lett., vol. 27, pp. 348-351, 2015. B. Li, S. Lou, and J. Aza?a, "Implementation of the photonic time-stretch concept using an incoherent pulsed light source," Appl. Opt., 54(10), pp. 2757-2761, 2015. B. Li, S. Lou, and J. Aza?a, "Novel Temporal Zone Plate Designs with Improved Energy Efficiency and Noise Performance," J. Lightwave Tech., 32(24), pp. 4201-4207, 2014. B. Li and J. Aza?a, "Incoherent-light temporal imaging of intensity waveforms," Opt. Photon. News, Year in optics, p. 33, 2014. B. Li and J. Aza?a, "Incoherent-light temporal stretching of high-speed intensity waveforms," Opt. Lett., 39(14), pp. 4243-4246, 2014. S. Chang, S. Lou, B. Li, and B. Han, "Parametric modulation to extend the aperture of the time lens based on electro-optics modulation", Acta. Opt. Sin., pp. 65-70, 2014. B. Li, M. Li, S. Lou, and J. Aza?a, "Linear optical pulse compression based on temporal zone plates," Opt. Express, 21(14), pp. 16814-16830, 2013. B. Li and S. Lou, "Elimination of Aberrations Due to High-Order Terms in Systems Based on Linear Time Lenses," J. Lightwave Tech., 31(13), pp. 2200-2206, 2013. B. Li and S. Lou, "Time-frequency conversion, temporal filtering and temporal imaging using graded-index time-lenses," Opt. Lett., 37(19), pp. 3981-3983, 2012. B. Li, S. Lou, and Z. Tan, "Two kinds of optical pulse compression approaches based on cross phase modulation," Acta. Phys. Sin. 61(19), 194203, 2012. B. Li, Z. Tan, and X. Zhang, "Simulation and analysis of time lens using cross phase modulation and four-wave mixing," Acta. Phys. Sin. 61(1), 014203, 2012. X. Zhang, Z. Tan, B. Li, and X. Sheng, "An optical-to-analog conversion technique based on temporal magnification," Optical Fiber & Electric Cable and Their Applications, 6, 26-29, 2011. B. Li, Z. Tan, and X. Zhang, "Experiment and simulation of time lens using electro-optic phase modulation and cross phase modulation," Acta. Phys. Sin. 60(8), 084204, 2011.