迟喻丹 - 复旦大学 - 脑科学转化研究院

个人简介

迟喻丹，国家优秀青年人才，脑科学转化研究院/附属华山医院研究院、博士生导师。主要从事中枢神经系统肿瘤与炎症相关研究，关注病理微环境的变化规律、中枢神经系统药物递送与靶向治疗。2016年中国科学院上海巴斯德研究所获得微生物学博士学位；2017-2020年美国纪念斯隆凯瑟琳癌症中心从事恶性中枢神经系统转移瘤的研究。迄今已在Science，Exploration，Mol Ther-Nucl Acids等国际高水平学术期刊发表论著，引用次数300余次，1项国内已授权专利，2项国际专利。其主要参与的软脑膜转移瘤铁螯合剂DFO治疗已进入临床试验。项目与荣誉科技部国家重点研发计划项目负责人（2023）国自然面上项目（2023）国自然青年科学项目（2023）复旦大学一健康基金优秀教师（2022）上海市自然科学基金 (2021) 上海市脑科学与类脑研究中心求索项目（2020）上海市教委东方学者 (2020) 美国癌症协会AACR Scholar-in-Training Award（2020）美国癌症协会AACR辉瑞基金（2020）美国纪念斯隆凯瑟琳癌症中心GMTEC基金（2019）

研究领域

主要从事中枢神经系统肿瘤与炎症的转化研究，注重阐述疾病发展规律和开发靶向微环境治疗的新策略。利用全基因组测序、单细胞转录组测序、空间组学以及代谢组学分析，深入研究肿瘤微环境对中枢神经系统的影响；结合中枢神经系统肿瘤小鼠模型探究新靶点的生物学功能、有效性和安全性；建立基于仿生纳米材料的中枢神经系统药物递送系统，对肿瘤细胞与微环境进行干预治疗。 1 中枢神经系统肿瘤微环境时空演进规律 2 肿瘤微环境代谢重编程 3 中枢神经系统药物递送与靶向治疗 4 中枢神经系统肿瘤或炎症引起颅内的损伤机制 5 脑脊液中肿瘤标志物的鉴定与生物学功能的分析

近期论文

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Pan L#, Peng H#, Lee B, Zhao J, Shen X, Yan X, Hua Y, Kim J, Kim D, Lin M, Zhang S, Li X, Yi X, Yao F, Qin Z, Du J, Chi Y*, Nam J*, Hyeon T*, Liu J *(2023). Cascade Catalytic Nanoparticles Selectively Alkalize Cancerous Lysosomes to Suppress Cancer Progression and Metastasis. Advanced Materials, Online Peng H, Yao F, Zhao J, Zhang W, Chen L, Wang X, Yang P*, Tang J*, Chi Y* (2023). Unraveling mitochondria-targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials. Exploration, 3(2):20220115 Chi Y, Remsik J, Kiseliovas V, Derderian C, Sener U, Alghader M, Saadeh F, Nikishina K, Bale T, Iacobuzio-Donahue C, Thomas T, Pe'er D, Mazutis L, Boire A*(2020). Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science, 369(6501):276-282. Remsik J, Chi Y, Tong X, Sener U, Derderian C, Park A, Saadeh F, Bale T, Boire A*(2020) Leptomeningeal metastatic cells adopt two phenotypic states. Cancer Reports, e1236. Zhang T, Choi S, Zhang T, Chen Z, Chi Y, Huang S, Xiang JZ, Du YN*(2020). miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor. Am J Pathol, 190(3):689-701 Wang X, Fang Z, Xiong J, Yang K, Chi Y, Tang X, Ma L, Zhang R, Deng F, Lan K, Zhou D*(2019). A chimpanzee adenoviral vector-based rabies vaccine protects beagle dogs from lethal rabies virus challenge. Virology, 536:32-38. Zhang G, Chi Y, Du YN*(2017). Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model. J Vis Exp, (128):55890. Zhang C, Chi Y, Zhou D*(2017). Development of Novel Vaccines Against Infectious Diseases Based on Chimpanzee Adenoviral Vector. Methods Mol Biol, 1581:3-13. Wang X, Fu W, Yuan S, Yang X, Song Y, Liu L, Chi Y, Cheng T, Xing M, Zhang Y, Zhang C, Yang Y, Zhu C, Zhang X, Xiong S, Xu J, Zhou D*(2017). Both haemagglutinin-specific antibody and T cell responses induced by a chimpanzee adenoviral vaccine confer protection against influenza H7N9 viral challenge. Sci Rep, 7(1):1854. Cheng T, Song Y, Zhang Y, Zhang C, Yin J, Chi Y, Zhou D*(2017). A novel oncolytic adenovirus based on simian adenovirus serotype 24. Oncotarget, 8(16):26871-26885. Chi Y, Zhou D*(2016). MicroRNAs in colorectal carcinoma--from pathogenesis to therapy. J Exp Clin Cancer Res, 10;35:43. Xing M, Wang X, Chi Y, Zhou D* (2016). Gene therapy for colorectal cancer using adenovirus-mediated full-length antibody, cetuximab. Oncotarget, 7(19):28262-72. Yang Y, Chi Y, Tang X, Ertl HCJ, Zhou D*(2016). Rapid, Efficient, and Modular Generation of Adenoviral Vectors via Isothermal Assembly. Curr Protoc Mol Biol, 113(1):16.26.1-16.26.18. Zhang C, Yang Y, Chi Y, Yin J, Yan L, Ku Z, Liu Q, Huang Z, Zhou D*(2015). Hexon-modified recombinant E1-deleted adenoviral vectors as bivalent vaccine carriers for Coxsackievirus A16 and Enterovirus 71. Vaccine, 33(39):5087-94 Chi Y, Wang X, Yang Y, Zhang C, Ertl HC, Zhou D*(2014). Survivin-targeting Artificial MicroRNAs Mediated by Adenovirus Suppress Tumor Activity in Cancer Cells and Xenograft Models. Mol Ther Nucleic Acids, 3(11):e208.