程田林 - 复旦大学 - 脑科学转化研究院

个人简介

程田林，脑科学转化研究院青年研究员，2008年毕业于复旦大学生物技术基地班获得理学学士学位，2014年毕业于中国科学院神经科学研究所获博士学位，随后中国科学院神经科学研究所担任助理研究员，2020年1月加入复旦大学脑科学转化研究院，主要研究方向为新型基因编辑工具的开发及神经系统疾病的基因治疗。主要研究成果发表在Developmental Cell、Nature Communications、Science Advances等学术杂志。

研究领域

主要研究方向为CRISPR为基础的新型基因编辑工具的开发及优化，并针对神经系统疾病开展基因治疗研究以推动基因编辑技术的临床转化。课题组主要运用分子生物学、细胞生物学、高通量筛选、流式细胞分选、RNA-Seq和单细胞测序等多种手段开展原创性的基因编辑技术研发工作。

近期论文

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Zhang, S., Song, L., Yuan, B., Zhang, C., Cao, J., Chen, J., Qiu, J., Tai, Y., Chen, J., Qiu, Z., Zhao, X. M., & Cheng, T. L. (2023). TadA reprogramming to generate potent miniature base editors with high precision. Nature communications, 14(1), 413 Zhang, S., Yuan, B., Cao, J., Song, L., Chen, J., Qiu, J., Qiu, Z., Zhao, X. M., Chen, J., & Cheng, T. L. (2023). TadA orthologs enable both cytosine and adenine editing of base editors. Nature communications, 14(1), 414. Li Shuo, Bo Yuan, Jixin Cao, Jingqi Chen, Jinlong Chen, Jiayi Qiu, Xing-Ming Zhao, Xiaolin Wang*, Zilong Qiu*, Tian-Lin Cheng* (2020). Docking sites inside Cas9 for adenine base editing diversification and RNA off-target elimination, Nature Communications, 11:5827. Tian-Lin Cheng*, Shuo Li, Bo Yuan, Xiaolin Wang, Wenhao Zhou, Zilong Qiu* (2019). Expanding C-T base editing toolkit with diversified cytidine deaminases, Nature Communications, 10:3612 Yuan Cai#,Tianlin Cheng#,Yichuan Yao#, Xiao Li, Yuqian Ma, Lingyun Li, Huan Zhao, Jin Bao, Mei Zhang*, Zilong Qiu*, Tian Xue*(2019). In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway, Science Advances, eaav3335 Tian-Lin Cheng*, Zilong Qiu*(2019). Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion, Protein Cell, 9: 820 Ling-jie He#, Nan Liu#, Tian-lin Cheng, Xiao-jing Chen, Yi-ding Li, Yousheng Shu, Zilong Qiu, and Xiaohui Zhang(2014). Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in absence of critical period plasticity, Nature communications, 5:5036 Tian-Lin Cheng, Zhizhi Wang, Qiuming Liao, Ying Zhu, Wen-Hao Zhou, Wenqing Xu, Zilong Qiu*(2014). MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex, Developmental Cell, 28:547-560